Ultrastructural megakaryocyte modifications after vanadium inhalation in spleen and bone marrow

Journal of Electron Microscopy

Volumn 58, Issue 6, 2009, Pages 375-380

  Fortoul, Teresa I ^a   González Villalva, Adriana ^a   Piñón Zarate, Gabriela ^a   Rodríguez Lara, Vianey ^a   Montaño, Luis F ^a   Saldivar Osorio, Liliana ^b  

^a School of Medicine   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Granules; Megakaryocytosis; Transition metals; Ultrastructure; Vanadium

Indexed keywords

TRACE ELEMENT; VANADIUM;

ANIMAL; ARTICLE; BONE MARROW; CELL GRANULE; DRUG EFFECT; EXPOSURE; MALE; MEGAKARYOCYTE; MOUSE; PATHOLOGY; SPLEEN; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; BONE MARROW; CYTOPLASMIC GRANULES; INHALATION EXPOSURE; MALE; MEGAKARYOCYTES; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; SPLEEN; TRACE ELEMENTS; VANADIUM;

MUS;

BONE; CELL PROLIFERATION; GRANULATION; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; MAMMALS; PLATELETS; VANADIUM PENTOXIDE;

AIR POLLUTANTS; BONE MARROW; EXPERIMENTAL MODELLING; GRANULE; MEGAKARYOCYTE; MEGAKARYOCYTIC; MEGAKARYOCYTOSI; MEMBRANE SYSTEM; ULTRASTRUCTURAL MODIFICATIONS; ULTRASTRUCTURE;

VANADIUM;

EID: 70849114151     PISSN: 00220744     EISSN: 14779986     Source Type: Journal    
DOI: 10.1093/jmicro/dfp031     Document Type: Article

References (27)

1. Bonner James, Rice A B, Moomaw C R, and Morgan D L (2000) Airway fibrosis in rats induced by vanadium pentoxide. Am. J. Physiol. Lung Cell Mol. Physiol. 278: 209-226.
2. Ivancsits S, Pilger A, Diem E, Schaffer A, and Rüdiger H W (2002) Vanadate induces DNA strand break in cultured human fibroblasts at doses relevant occupational exposure. Genet. Toxicol. Environ. Mutagen. 519: 25-35.
3. Nriagu J O (1998) Vanadium in the Environment (Wiley, New York).
4. Fortoul T I, Saldivar O L, Tovar T A, Salazar D, Castilla M E, and Olaiz F G (1996) Metals in lung tissue from autopsy cases in Mexico City residents. Comparison between cases from the 1950's and the 1980's. Environ. Health Perspect. 104: 630-632.
5. Fortoul T I, Mendoza M L, Ávila M C, Quan T A, Saldivar O L, Espejel M G, Navarro-Villanueva D, Avila-Costa M R, Colin-Barenque L, Bizarro P, and Olaiz F G (2002) Vanadium in ambient air. Concentrations in lung tissue from autopsies of Mexico City residents in the 1960s and 1990s. Autopsies from the sixties and the nineties. Arch. Environ. Health 57: 446-449.
6. Gonzalez-Villalva A, Fortoul T I, Avila-Costa M R, Piñ on-Zarate G, Rodriguez-Lara V, Martinez-Levy G, Rojas-Lemus M, Bizarro- Nevarez P, Diaz-Bech P, Mussali-Galante P, and Colin-Barenque L (2006) Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation. Toxicol. Ind. Health 22: 113-116.
7. Fortoul T I, Piñ ón-Zarate G, Diaz-Bech M E, Gonzá lez-Villalva A, Mussali-Galante P, Rodriguez-Lara V, Colin-Barenque L, Martinez- Pedraza M, and Montañ O L F (2008) Spleen and bone marrow megakaryocytes as targets for inhaled vanadium. Histol. Histopathol. 23: 1321-1326.
8. Kaushansky K (2008) Historical review: megakaryopoiesis and thrombopoiesis. Blood 111: 981-986.
9. Zink D, Fischer A H, and Nickerson J A (2004) Nuclear structure in cancer cells. Cancer Nat. Rev. 4: 677-687.
10. Tenedini E, Fagioli M E, Vianelli N, Tazzari P L, Ricci F, Tagliafico E, Ricci P, Gugliotta L, Martinelli G, Tura S, Baccarani M, Ferrari S, and Catani L (2004) Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells. Blood 104: 3126-3135.
11. Lannutti B, Minear J, Blake N, and Drachman J G (2006) Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene 25: 3316-3324.
12. Samet J M, Graves L M, Quay J, Dailey L A, Devlin R B, Ghio A J, Wu W, Bromberg P A, and Reed W (1998) Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am. J. Physiol. Lung Cell. Mol. Physiol. 275: L551-L558.
13. Italiano J E, Richardson J L, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, and Klement G (2008) Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet á granules and differentially released. Blood 111: 1227-1233.
14. Kawato M, Shirakawa R, Kondo H, Higashi T, Ikeda T, Okawa K, Fukai S, Nureki O, Kita T, and Horiuchi H (2008) Regulation of platelet dense granule secretion by the Ral GTPase-exocytosis pathway. J. Biol. Chem. 283: 166-174.
15. Reed G L (2007) Platelet secretion. In: Michelson A D (ed.), Platelets (Elsevier, Amsterdam).
16. Tomer A (2004) Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N)megakaryocytes. Blood 104: 2722-2727.
17. Flaumenhaft R, Dilks J R, Rozenvayn N, Monahan-Earley R A, Feng D, and Dvorak A M (2005) The actin cytoskeleton differentially regulates platelet á-granule and dense-granule secretion. Blood 105: 3879-3887.
18. Ramirez P, Eastmond D A, Laclette J P, and Ostrosky-Wegman P (1997) Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat. Res. 386: 291-298.
19. Kirito K, Osawa M,Morita H, Shimizu S, Yamamoto M, Oda A, Fujita H, Tanaka M, Nakajim K, Miura Y, Ozawa K, and Komatsu N (2002) A functional role of Stat3 in vivo megakaryopoyesis. Blood 99: 3220-3227.
20. Steensma D P (2006) JAK2 V617F in myeloid disorders: molecular diagnostic techniques and their clinical utility. J. Mol. Diagn. 8: 397-411.
21. Vannucchi A M, Bianchi L, Paoletti F, Pancrazzi A, Torre E, Nishikawa M, Zingariello M, Di Baldassarre A, Rana R A, Lorenzini R, Alfani E, Migliaccio G, and Migliaccio A R (2005a) A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-1 in the development of myelofibrosis. Blood 105: 3493-3501.
22. Vannucchi M A, Pancrazzi A, Guglielmelli P, Di Lollo S, Bogani C, Baroni G, Bianchi L, Migliaccio A R, Bosi A, and Paoletti F (2005b) Abnormalities of GATA-1 in Megakaryocytes from Patients with Idiopathic Myelofibrosis. Am. J. Pathol. 167: 849-858.
23. Kamata T, Kang J, Lee T H, Wojnowski L, Pritchard C A, and Leavitt A D (2005) A critical function for B-Raf at multiple stages of myelopoiesis. Blood 106: 833-840.
24. Metcalf D, Carpinelli M R, Hyland C, Mifsud S, DiRago L, Nicola N A, Hilton D J, and Alexander W S (2005) Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood 105: 3480-3487.
25. Li Z, Godinho F J, Klusmann J H, Garriga-Canut M, Yu C, and Orkin S H (2005) Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat. Genet. 37: 613-619.
26. Suna L, Khe Hwang W Y, and A wa S E (2006) Biological characteristics of megakaryocytes: Specific lineage commitment and associated disorders. Int. J. Biochem. Cell Biol. 38: 1821-1826.
27. Leonard S S, Harris G K, and Shi X (2004) Metal-induced oxidative stress and signal transduction. Free Radic. Biol. Med. 37: 1921-1942.