Underdosing of ertapenem in critically ill patients with pneumonia confirmed by Monte Carlo simulations

International Journal of Antimicrobial Agents

Volumn 35, Issue 1, 2010, Pages 96-97

  Burkhardt, Olaf ^a,b   Kumar, Vipul ^c   Schmidt, Stephan ^c   Kielstein, Jan T ^a   Welte, Tobias ^a   Derendorf, Hartmut ^c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Central Clinic Bad Berka   (Germany)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERTAPENEM; METICILLIN; PENICILLIN G;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL PNEUMONIA; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; COMPARTMENT MODEL; CRITICALLY ILL PATIENT; DRUG CLEARANCE; DRUG DISTRIBUTION; HUMAN; LETTER; MINIMUM INHIBITORY CONCENTRATION; MONTE CARLO METHOD; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CRITICAL ILLNESS; HUMANS; MONTE CARLO METHOD; PLASMA; PNEUMONIA, BACTERIAL;

EID: 70849107014     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2009.09.007     Document Type: Letter

References (6)

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2. Burkhardt O., Kumar V., Katterwe D., Majcher-Peszynska J., Drewelow B., Derendorf H., et al. Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration. J Antimicrob Chemother 59 (2007) 277-284
3. Burkhardt O., Hafer C., Langhoff A., Kaever V., Kumar V., Welte T., et al. Pharmacokinetics of ertapenem in critically ill patients with acute renal failure undergoing extended daily dialysis. Nephrol Dial Transplant 24 (2009) 267-271
4. Brink A.J., Richards G.A., Schillack V., Kiem S., and Schentag J. Pharmacokinetics of once-daily dosing of ertapenem in critically ill patients with severe sepsis. Int J Antimicrob Agents 33 (2009) 432-436
5. Burkhardt O., Majcher-Peszynska J., Borner K., Mundkowski R., Drewelow B., Derendorf H., et al. Penetration of ertapenem into different pulmonary compartments of patients undergoing lung surgery. J Clin Pharmacol 45 (2005) 659-665
6. Schuck E.L., and Derendorf H. Pharmacokinetic/pharmacodynamic evaluation of anti-infective agents. Expert Rev Anti Infect Ther 3 (2005) 361-373