Novel factor-loaded polyphosphazene matrices: Potential for driving angiogenesis

Journal of Microencapsulation

Volumn 26, Issue 6, 2009, Pages 544-555

  Oredein Mccoy, Olugbemisola ^b   Krogman, Nicholas R ^c   Weikel, Arlin L ^c   Hindenlang, Mark D ^c   Allcock, Harry R ^c   Laurencin, Cato T ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b University of Virginia   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Angiogenesis; Hydroxyapatite; Nanocrystalline; Polyphosphazene; Solvent sintering; VEGF

Indexed keywords

ANGIOGENIC FACTOR; BOVINE SERUM ALBUMIN; FLUORESCEIN ISOTHIOCYANATE; HYDROXYAPATITE; MICROSPHERE; PHOSPHORUS DERIVATIVE; POLY(ETHYL PHENYLALANATO:GLYCINATO)PHOSPHAZENE; POLYMER; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BONE TISSUE; CIRCULAR DICHROISM; CONFOCAL MICROSCOPY; FEMALE; NONHUMAN; POROSITY; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; SCANNING ELECTROCHEMICAL MICROSCOPY; TRABECULAR BONE;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; CATTLE; CIRCULAR DICHROISM; DURAPATITE; ORGANOPHOSPHORUS COMPOUNDS; POLYMERS; POROSITY; SERUM ALBUMIN, BOVINE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 70849103437     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040802500473     Document Type: Article

References (39)

1. Allcock HR. 2003. Chemistry and applications of polyphosphazenes. New York: Wiley-Interscience Ch 15.
2. Allcock HR, Fuller TJ, Mack DP, Matsumura K, Smeltz KM. 1977. Synthesis of poly[(amino acid alkyl ester)phosphazenes]. Macromolecules 10:824-830.
3. Allcock HR, Fuller TJ, Matsumura K. 1982. Hydrolysis pathways for aminophosphazenes. Inorg Chem 21:515-521.
4. Allcock HR, Kwon S. 1988. Glyceryl polyphosphazenes: Synthesis, properties and hydrolysis. Macromolecules 21:1980-1985.
5. Allcock HR, Pucher SR. 1991. Polyphosphazenes with glycosyl and methyl amino, trifluoroethoxy, phenoxy or (methoxyethoxy)ethoxy side groups. Macromolecules 24:23-34.
6. Allcock HR, Pucher SR, Scopelianos AG. 1994. Poly[(amino acid ester)phosphazenes]: synthesis, crystallinity and hydrolytic sensitivity in solution and the solid state. Macromolecules 27:1071-1075.
7. Allcock HR, Pucher SR, Scopelianos AG. 1994. Synthesis of poly(organophosphazenes) with glycolic acid ester and lactic acid ester side groups: prototypes for new bioerodible polymers. Macromolecules 27:1-4.
8. Bell AJ, Talbot-Stern JK, Hennessy A. 2000. Characteristics and outcomes of older patients presenting to the emergency department after a fall: a retrospective analysis. Med J Aust 173:176-177.
9. Borden M, Attawia M, Khan Y, El-Amin S F, Laurencin CT. 2004. Tissueengineered bone formation in vivo using a novel sintered polymeric microsphere matrix. J Bone Joint Surg Brit Vol 86B:1200-1208.
10. Borden M, Attawia M, Laurencin CT. 2002. The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies. J Biomed Mater Res 61:421-442.
11. Borden M, El-Amin SF, Attawia M, Laurencin CT. 2003. Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials 24:597-609.
12. Brown JL, Nair LS, Laurencin CT. 2007. Solvent/non-solvent sintering: A novel route to create porous microsphere scaffolds for tissue regeneration. J Biomed Mater Res B Appl Biomater 86B(2):396-1306
13. Carter DR, Hayes WC. 1977. The compressive behavior of bone as a twophase porous structure. J Bone Joint Surg Am 59:954-962.
14. Crommen JHL, Schacht EH, Mense EHG. 1992. Biodegradable polymers I. Synthesis of hydrolysis-sensitive poly[(organo)phosphazenes]. Biomaterials 13:511-520.
15. Einhorn T. 1996. Chapter 3, Biomechanics of bone. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology San Diego: Academic Press. pp 25-38.
16. Hornbrook MC, Stevens VJ, Wingfield DJ, Hollis JF, Greenlick MR, Ory MG. 1994. Preventing falls among community-dwelling older persons: Results from a randomized trial. Gerontologist 34:16-23.
17. Jiang W, Schwendeman SP. 2001. Stabilization and controlled release of bovine serum albumin encapsulated in poly(D, L-lactide and poly(ethylene glycol) microsphere blends. Pharm Res 18:878-885.
18. Kleinheinz J, Stratmann U, Joos U, Wiesmann H-P. 2005. VEGF-activated angiogenesis during bone regeneration. J Oral Maxillofac Surg 63:1310-1316.
19. Langer R, Moses M. 1991. Biocompatible controlled release polymers for delivery of polypeptides and growth factors. J Cell Biochem 45:340-345.
20. Laurencin CT, El-Amin SF, Ibim SE, Willoughby DA, Attawia M, Allcock HR, et al. 1996. A highly porous 3-dimensional polyphosphazene polymer matrix for skeletal tissue regeneration. J Biomed Mater Res 30:133-138.
21. Laurencin CT, Koh HJ, Neenan TX, Allcock HR, Langer R. 1987. Controlled release using a new bioerodible polyphosphazene matrix system. J Biomed Mater Res 21:1231-1246.
22. Laurencin CT, Morris C, Pierre-Jacques H, Schwartz E. 1992. Osteoblast culture on bioerodible polymers: Studies of initial cell adhesion and spread. Polym Adv Tech 3:359-364.
23. Laurencin CT, Norman ME, Elgendy HM, El-Amin SF, Allcock HR, Pucher SR, et al. 1993. Use of polyphosphazenes for skeletal tissue regeneration. J Biomed Mater Res 27:963-973.
24. Laurencin CT, Norman ME, Elgendy HM, El-Amin SF, Allcock HR, Pucher SR, et al. 1993. Use of polyphosphazenes for skeletal tissue regeneration. J Biomed Mater Res 27:963-973.
25. Laurenicin CT, Ambrosio AMA, Bauer TW, Allcock HR, Attawia MA, Borden MD, Gorum WJ, Frank D. 1998. The biocompatibility of polyphosphazenes. Evaluation in bone. Society for Biomaterials 24th annual meeting in conjunction with 30th international symposium. San Diego: CA.
26. Liu X, Ma PX. 2004. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 32:477-486.
27. Matsumoto T, Okazaki M, Inoue M, Yamaguchi S, Kusunose T, Toyonaga T, et al. 2004. Hydroxyapatite particles as a controlled release carrier of protein. Biomaterials 25:3807-3812.
28. Midy V, Hollande E, Rey C, Dard M, Plouet J. 2001. Adsorption of vascular endothelial growth factor to two different apatitic materials and its release. J Mater Sci Mater Med 12:293-298.
29. Murphy WL, Simmons CA, Kaigler D, Mooney DJ. 2004. Bone regeneration via a mineral substrate and induced angiogenesis. J Dent Res 83:204-210.
30. Nukavarapu SP, Kumbar SG, Brown JL, Krogman NR, Weikel AL, Hindenlang MD, Nair LS, Allcock HR, Laurencin CT. 2008. Polyphosphazene/nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering. Biomacromolecules 9(7):1818-1825.
31. Passi P, Zadro A, Marsilio F, Lora S, Caliceti P, Veronese FM. 2000. Plain and drug loaded polyphosphazene membranes and microspheres in the treatment of rabbit bone defects. J Mater Sci Mater Med 11:643-654.
32. Peters MC, Polverini PJ, Mooney DJ. 2002. Engineering vascular networks in porous polymer matrices. J Biomed Mater Res 60:668-678.
33. Ramchandania M, Robinson D. 1998. In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants. J Contr Rel 54:167-175.
34. Ruiz EM, Ramirex CA, Aponte MA, Barbosa-Canovas GV. 1993. Degradation of poly[bis(glycine ethyl ester)]phosphazene in aqueous media. Biomaterials 14:491-496.
35. Schrier JA, DeLuca PP. 1999. Recombinant human bone morphogenetic protein-2 binding and incorporation in vitro PLGA microsphere delivery systems. Pharm Dev Tech 4:611-621.
36. Siepmann J, Göpferich A. 2001. Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv Drug Del Rev 48:229-247.
37. Stevens JA, Olson S. 2000. Reducing falls and resulting hip fractures among older women. National Center for Injury Prevention and Control Division of Unintentional Injury Prevention; MMWR Recomm Rep. 49(RR-2):3-12.
38. Street J, Bao M, deGuzman S, Peale FV, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, van Bruggen N, Redmond HP, Carano RAD, Filvaroff EH. 2002. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. PNAS 99:9656-9661.
39. Uchida T, Yoshida K, Goto S. 1996. Preparation and characterization of polylactic acid microspheres containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method. J Microencapsulation 13:219-228.