Activation of the lung S1P 1 receptor reduces allergen-induced plasma leakage in mice

British Journal of Pharmacology

Volumn 158, Issue 5, 2009, Pages 1295-1301

  Ble F X ^a,b   Cannet, C ^a   Zurbruegg, S ^a   Gerard C ^a   Frossard, N ^b   Beckmann, N ^a   Trifilieff, A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Asthma; Magnetic resonance imaging; Mouse; Plasma leakage; Sphingosine 1 phosphate type 1 receptor

Indexed keywords

3 [2 (3 TRIFLUOROMETHYL 4 BIPHENYLYL)BENZO[B]THIEN 5 YLMETHYLAMINO]PROPIONIC ACID; ALLERGEN; BUDESONIDE; FINGOLIMOD; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; INFLAMMATORY CELL; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADMINISTRATION, INTRANASAL; ALLERGENS; ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; BETA-ALANINE; BUDESONIDE; CAPILLARY PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMMUNOLOGIC FACTORS; LUNG; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PNEUMONIA; PROPYLENE GLYCOLS; PULMONARY EDEMA; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; THIOPHENES;

EID: 70849103427     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00391.x     Document Type: Article

References (17)

1. Beckmann N, Tigani B, Ekatodramis D, Borer R, Mazzoni L, Fozard JR (2001). Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging. Magn Reson Med 45: 88-95. (Pubitemid 32044269)
2. Ble FX, Cannet C, Zurbruegg S, Karmouty-Quintana H, Bergmann R, Frossard N et al. (2008). Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging. Radiology 248: 834-843.
3. Brinkmann V (2007). Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 115: 84-105.
4. Chalfant CE, Spiegel S (2005). Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci 118: 46054612.
5. Goetzl EJ, Kong Y, Mei B (1999). Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. J Immunol 162: 2049-2056. (Pubitemid 29288824)
6. Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J et al. (2005). S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Proc Natl Acad Sci USA 102: 9270-9275. (Pubitemid 40923553)
7. Idzko M, Hammad H, van NM, Kool M, Muller T, Souille T et al. (2006). Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J Clin Invest 116: 2935-2944. (Pubitemid 44684478)
8. Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJA et al. (2001). Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G proteincoupled receptor, LPB3/EDG-3. J Biol Chem 276: 33697-33704.
9. McVerry BJ, Garcia JG (2005). In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal 17: 131-139.
10. Pan S, Mi Y, Pally C, Beerli C, Chen A, Guerini D et al. (2006). A monoselectlve sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol 13: 1227-1234. (Pubitemid 44762192)
11. Peng X, Hassoun PM, Sammani S, McVerry BJ, Burne MJ, Rabb H et al. (2004). Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med 169: 1245-1251. (Pubitemid 38680403)
12. Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V et al. (2003). Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem 278: 47281-47290. (Pubitemid 37452317)
13. Sanchez T, Skoura A, Wu MT, Casserly B, Harrington EO, Hla T (2007). Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vase Biol 27: 1312-1318. (Pubitemid 46809419)
14. Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP et al. (2006). Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol 2: 434-441. (Pubitemid 44114922)
15. Sawicka E, Zuany-Amorim C, Manlius C, Trifilieff A, Brinkmann V, Kemeny DM et al. (2003). Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. J Immunol 171: 6206-6214. (Pubitemid 37467244)
16. Tigani B, Schaeublin E, Sugar R, Jackson AD, Fozard JR, Beckmann N (2002). Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats. Biochem Biophys Res Commun 292: 216221. (Pubitemid 34687351)
17. Tigani B, Cannet C, Zurbrugg S, Schaeublin E, Mazzoni L, Fozard JR et al. (2003). Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging. Br J Pharmacol 140: 239-246. (Pubitemid 37249182)