The functional changes of the perivascular adipose tissue in spontaneously hypertensive rats and the effects of atorvastatin therapy

Clinical and Experimental Hypertension

Volumn 31, Issue 4, 2009, Pages 355-363

  Zeng, Zhao Hua ^a   Zhang, Zhen Hong ^a   Luo, Bi Hui ^a   He, Wen Kai ^a   Liang, Li Ying ^a   He, Chao Chu ^a   Su, Cheng Jian ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Adipose tissue; Adventitium derived relaxing factor (ADRF); Atrovastatin; Hypertension; Perivascular adipocyte derived relaxation factor (PVRF); Statin; Vessel relaxation

Indexed keywords

ATORVASTATIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; GLIBENCLAMIDE; INDOMETACIN; PHENYLEPHRINE; TETRYLAMMONIUM CHLORIDE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM METABOLISM; CONTROLLED STUDY; DRUG EFFECT; ESSENTIAL HYPERTENSION; EXTRACELLULAR CALCIUM; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR RING; VASCULAR SMOOTH MUSCLE; WISTAR KYOTO RAT;

ADIPOSE TISSUE; ANIMALS; AORTA, THORACIC; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION; MALE; PYRROLES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASOCONSTRICTION; VASODILATION;

EID: 70849097968     PISSN: 10641963     EISSN: 15256006     Source Type: Journal    
DOI: 10.1080/10641960902977916     Document Type: Article

References (16)

1. Jones DW. Dietary sodium and blood pressure. Hypertension 2004; 43:932-935.
2. Abate N. Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications. J. Diabetes Complications 2000; 14:154-174.
3. Zeng ZH, Luo BH, Gao YJ, Su CJ, He CC, Li N, Lee RM. Arterial structural changes in hypertensive rats induced by capsaicin and salt loading. Clin Exp Pharmacol Physiol 2004; 31:502-505.
4. Zeng ZH, Luo BH, Gao YJ, Su CJ, He CC, Yi JJ, Li N, Lee RM. Control of vascular changes by Renin-angiotensin-aldosterone system in salt-sensitive hypertension. Eur J Pharmacol 2004; 503:129-133.
5. Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM. Periadventitial fat releases a vascular relaxing factor. FASEB J 2002; 16:1057-1063.
6. Gao YJ, Holloway AC, Zeng ZH, Lim GE, Petrik JJ, Foster WG, Lee RM. Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function. Obes Res 2005; 13:687-692.
7. Verlohren S, Dubrovska G, Tsang SY, Essin K, Luft FC, Huang Y, Gollasch M. Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 2004; 44:271-276. (Pubitemid 39167221)
8. Gao YJ, Zeng ZH, Teoh K, Sharma AM, Abouzahr L, Cybulsky I, Lamy A, Semelhago L, Lee RM. Perivascular adipose tissue modulates vascular function in the human internal thoracic artery. J Thorac Cardiovasc Surg 2005; 130(4):1130-1136.
9. Sharma, A.M. Obesity and cardiovascular risk. Growth Horm IGF Res 2003; 13:S10-S17.
10. Sowers, J.R. Obesity and cardiovascular disease. Clin Chem 1998; 44:1821-1825.
11. Jiang J, Roman RJ. Lovastatin prevents development of hypertension in spontaneously hypertensive rats. Hypertension 1997; 30:968-974.
12. Ferrier KE, Muhlmann MH, Baguet JP, Cameron JD, Jennings GL, Dart AM, Kingwell BA. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. J Am Coll Cardiol 2002; 39(6):1020-1025.
13. Kishi T, Hirooka Y, Mukai Y, Shimokawa H, Takeshita A. Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats. J Hypertens 2003; 21(2):379-386.
14. Farmer JA, Gotto AMJR. Choosing the right lipid-regulating agent. A guide to selection. Drugs 1996; 52:649-661.
15. Grundy SM. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl J Med 1988; 319:24-33.
16. Gao YJ, Lu C, Su LY, Sharma AM, Lee RM. Modulation of vascular function by perivascular adipose tissue: The role of endothelium and hydrogen peroxide. Br J Pharmacol 2007; 151(3):323-331.