Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma

Histopathology

Volumn 55, Issue 6, 2009, Pages 687-695

  Yusenko, Maria V ^a   Kovacs, Gyula ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

CD82 KAI1; Chromophobe renal cell carcinoma; Immunohistochemistry; RT PCR; Tissue array

Indexed keywords

CD82 ANTIGEN;

ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; CELLULAR DISTRIBUTION; CLEAR CELL SARCOMA; CONTROLLED STUDY; DISEASE MARKER; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; WESTERN BLOTTING;

ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; CELLS, CULTURED; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; KANGAI-1 PROTEIN; KIDNEY; KIDNEY NEOPLASMS; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL;

EID: 70849085167     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2009.03449.x     Document Type: Article

References (37)

1. Akhtar M, Kfoury H, Linjawi T, Kovacs G. Sarcomatoid chromophobe cell carcinoma of the kidney. J. Urol. Pathol. 1996 4 155 166.
2. Badoual C, Tissier F, Lagorce-Pages C, Delcourt A, Vieillefond A. Pulmonary metastases from a chromophobe renal cell carcinoma: 10 years' evolution. Histopathology 2002 40 300 302.
3. Crotty TB, Farrow GM, Lieber MM. Chromophobe cell renal carcinoma: clinicopathological feature of 50 cases. J. Urol. 1995 154 964 967.
4. Renshaw AA, Henske EP, Loughlin KR, Shapiro C, Weinberg DS. Aggressive variants of chromophobe renal cell carcinoma. Cancer 1996 78 1756 1761.
5. Davis CJ, Sesterhenn IA, Mostofi FK, Ho CK. Renal oncocytoma. Clinicopathological study of 166 patients. J. Urogenital Pathol. 1991 1 41 52.
6. Kovacs A, Kovacs G. Low chromosome number in chromophobe renal cell carcinomas. Genes Chromosomes Cancer 1992 4 267 268.
7. Speicher MR, Schoell B, du Manoir S et al. Specific loss of chromosomes 1, 2, 6, 10, 13, 17 and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridisation. Am. J. Pathol. 1994 145 356 364.
8. Bugert P, Gaul C, Weber K, Akhtar M, Ljungberg B, Kovacs G. Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas. Lab. Invest. 1997 76 203 208.
9. Bugert P, Kovacs G. Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis. Am. J. Pathol. 1996 149 2081 2088.
10. Nagy A, Buzogany I, Kovacs G. Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changes. Histopathology 2004 44 542 546.
11. Wilhelm M, Veltman JA, Olshen A et al. Array based CGH for the differential diagnosis of renal cell cancer. Cancer Res. 2002 62 957 960.
12. Kovacs G, Akhtar M, Beckwith BJ et al. The Heidelberg classification of renal cell tumours. J. Pathol. 1997 183 131 133.
13. Kauffman EC, Barocas DA, Yang XJ, Liu H, Scherr DS, Tu JJ. KAI1 is a novel biomarker for chromophobe renal cell carcinoma. The Annual Meeting of the American Urological Association (AUA). May 17-22, 2008. Orlando, Florida, USA.
14. Takahashi M, Yang XY, Sugimura J et al. Molecular subclassification of kidney tumors and the discovery of new diagnostic markers. Oncogene 2003 22 6810 6818.
15. Young AN, Amin MB, Moreno CS et al. Expression profiling of renal epithelial neoplasms. Am. J. Pathol. 2001 58 1639 1651.
16. Higgins JPT, Shinghal R, Gill H et al. Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am. J. Pathol. 2003 162 925 932.
17. Schuetz AN, Yin-Goen Q, Amin MB et al. Molecular classification of renal tumors by gene expression profiling. J. Mol. Diagn. 2005 7 206 218.
18. Rohan S, Tu JJ, Kao J et al. Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin. Cancer Res. 2006 12 6937 6945.
19. Koeman JM, Russell RC, Tan MH et al. Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated ELGN2-mediated oxygen-sensing response. PLoS Genet. 2008 4 e1000176.
20. Wu SL, Kothari P, Wheeler TM, Reese T, Connelly JH. Cytokeratins 7 and 20 immunoreactivity in chromophobe renal cell carcinomas and renal oncocytomas. Mod. Pathol. 2002 15 712 717.
21. Abrahams NA, MacLennan GT, Khoury JD et al. Chromophobe renal cell carcinoma: a comparative study of histological, immunohistochemical and ultrastructural features using high throughput tissue microarray. Histopathology 2004 45 593 602.
22. Young AN, de Oliveira Salles PG, Lim SD et al. Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohistochemical markers for renal tumours derived from gene expression profiling studies using cDNA microarrays. Am. J. Surg. Pathol. 2003 27 199 205.
23. Mazal PR, Exner M, Haitel A et al. Expression of kidney specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum. Pathol. 2005 36 22 28.
24. Chen YT, Tu JJ, Kao J, Zhou XK, Mazumdar M. Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma. Clin. Cancer Res. 2005 11 6558 6566.
25. Adachi M, Taki T, Ieki Y, Huang CL, Higashiyama M, Miyake M. Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer. Cancer Res. 1996 56 1751 1755.
26. Dong JT, Lamb PW, Rinker-Schaeffer CW et al. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 1995 268 884 886.
27. Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC. Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res. 1999 59 5724 5731.
28. Yang X, Wei L, Tang C, Slack R, Montgomery E, Lippman M. KAI1 protein is down-regulated during the progression of human breast cancer. Clin. Cancer Res. 2000 6 3424 3429.
29. Liu FS, Chen JT, Dong JT et al. KAI1 metastasis suppressor gene is frequently down-regulated in cervical carcinoma. Am. J. Pathol. 2001 159 1629 1634.
30. Schindl M, Birner P, Breitenecker G, Oberhuber G. Downregulation of KAI1 metastasis suppressor protein is associated with a dismal prognosis in epithelial ovarian cancer. Gynecol. Oncol. 2001 83 244 248.
31. Liu FS, Dong JT, Chen JT, Hsieh YT, Ho ES, Hung MJ. Frequent down-regulation and lack of mutation of the KAI1 metastasis suppressor gene in epithelial ovarian carcinoma. Gynecol. Oncol. 2000 78 10 15.
32. Shihonara T, Nishimura N, Hanibuchi M et al. Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice. Int. J. Cancer 2001 94 16 23.
33. Yang X, Wei LL, Tang C, Slack R, Muller S, Lippman ME. Overexpression of KAI1 suppressor in vitro invasiveness and in vivo metastasis in breast cancer cells. Cancer Res. 2001 61 5284 5288.
34. White A, Lamb PW, Barrett JC. Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines. Oncogene 1998 16 3143 3149.
35. Mashimo T, Watabe M, Hirota S et al. The expression of the KAI1 gene, a tumour metastasis suppressor, is directly activated by p53. Proc. Natl Acad. Sci. USA 1998 96 11307 11311.
36. Shinohara T, Miki T, Nishimura N et al. Nuclear factor-kB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53. Cancer Res. 2001 61 673 678.
37. Jackson P, Puisieux A. Is the KAI1 metastasis suppressor gene a cellular target of p53? A review of current evidence. Biochem. Biophys. Res. Commun. 2000 278 499 502.