Plasma protein kinase C (PKC)α as a biomarker for the diagnosis of cancers

Carcinogenesis

Volumn 30, Issue 11, 2009, Pages 1927-1931

  Kang, Jeong Hun ^a,c   Asai, Daisuke ^b   Toita, Riki ^a   Kitazaki, Hirotaro ^a   Katayama, Yoshiki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (3 AMINOPROPYL) 3 INDOLYL] 4 (1 METHYL 3 INDOLYL) 1H PYRROLE 2,5 DIONE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; ROTTLERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RECURRENCE; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TUMOR VOLUME; WESTERN BLOTTING;

ACETOPHENONES; ANIMALS; BENZOPYRANS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; HUMANS; INDOLES; ISOQUINOLINES; MALE; MALEIMIDES; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTEIN KINASE INHIBITORS; SULFONAMIDES; TUMOR MARKERS, BIOLOGICAL;

EID: 70849083521     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp210     Document Type: Article

References (39)

1. Sidransky,D. (2002) Emerging molecular markers of cancer. Nat. Rev. Cancer, 2, 210-219.
2. Harris,L. et al. (2007) American society of clinical oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J. Clin. Oncol., 25, 5287-5312.
3. Chatterjee,S.K. et al. (2005) Cancer biomarkers: Knowing the present and predicting the future. Future Oncol., 1, 37-50.
4. Roos,P.H. et al. (2008) Predictive biomarkers and signature in urinary bladder cancer. Curr. Opin. Mol. Ther., 10, 243-250.
5. Schrohl,A.-S. et al. (2008) Banking of biological fluids for studies of disease-associated protein biomarkers. Mol. Cell. Proteomics, 7, 2061-2066.
6. Decramer,S. et al. (2008) Urine in clinical proteomics. Mol. Cell. Proteomics, 7, 1850-1862.
7. Wong,D.T. (2006) Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J. Am. Dent. Assoc., 137, 313-321.
8. Damber,J.-E. et al. (2008) Prostate cancer. Lancet, 371 1710-1721.
9. Adjei,A.A. et al. (2005) Intracellular signal transduction pathway proteins as targets for cancer therapy. J. Clin. Oncol., 23, 5386-5403.
10. Velculescu,W.E. (2008) Defining the blueprint of the cancer genome. Carcinogenesis, 29, 1087-1091.
11. Bode,A.M. et al. (2005) Signal transduction pathways in cancer development and as targets for cancer prevention. Prog. Nucleic Acid Res. Mol. Biol., 79, 237-297.
12. Newton,A.C. (1997) Regulation of protein kinase C. Curr. Opin. Cell Biol., 9, 161-167.
13. Blobe,G.C. et al. (1994) Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev., 13, 411-431.
14. Webb,B.L.J. et al. (2000) Protein kinase C isoenzymes: A review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis. Br. J. Pharmacol., 130, 1433-1452.
15. Oka,M. et al. (2005) Protein kinase C in melanoma. Cancer Metastasis Rev., 24, 287-300.
16. Mackay,H.J. et al. (2003) Protein kinase C: A target for anticancer drugs? Endocr. Relat. Cancer, 10, 389-396.
17. Hofmann,J. (2004) Protein kinase C isozymes as potential targets for anticancer therapy. Curr. Cancer Drug Targets, 4, 125-146.
18. Goekjian,P.G. et al. (2001) Protein kinase C inhibitors as novel anticancer drugs. Expert Opin. Investig. Drugs, 10, 2117-2140.
19. O'Brian,C.A. et al. (2006) Protein kinase Ca and e small-molecule targeted therapeutics: A new roadmap to two holy grails in drug discovery? Expert Rev. Anticancer Ther., 6, 175-186.
20. Kang,J.-H. et al. (2008) A short peptide is a protein kinase C (PKC)α-specific substrate. Proteomics, 8, 2006-2011.
21. Kang,J.-H. et al. (2008) Design of polymeric carriers for cancer-specific gene targeting: Utilization of abnormal protein kinase Cα activation in cancer cells. J. Am. Chem. Soc., 130, 14906-14907.
22. Kang,J.-H. et al. (2007) Mass-tag technology responding to intracellular signals as a novel assay system for the diagnosis of tumor. J. Am. Soc. Mass Spectrom., 18, 106-112.
23. Kang,J.-H. et al. (2007) Effect of the addition of diammonium citrate to a-cyano-4-hydroxycinnamic acid (CHCA) matrix for the detection of phosphorylated peptide in phosphorylation reactions using cell and tissue lysates. J. Am. Soc. Mass Spectrom., 18, 1925-1931.
24. Coligan,J.E. et al. (eds) (1996) Current Protocols in Protein Science, John Wiley & Sons, Inc, Indianapolis, IN, Vol. 2, pp. 16.2.1-16.2.11.
25. Yang,X. et al. (2004) Enhanced ionization of phosphorylated peptides during MALDI-TOF mass spectrometry. Anal. Chem., 76, 1532-1536.
26. Collins,M.O. et al. (2007) Analysis of protein phosphorylation on a proteome- scale. Proteomics, 7, 2751-2768.
27. Shimizu,A. et al. (2005) Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry. Mass Spectrom. Rev., 25, 686-712.
28. Davies,S.P. et al. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J., 351 95-105.
29. Wilkinson,S.E. et al. (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J., 294, 335-337.
30. Murphy,C.T. et al. (1992) Selective inhibition of protein kinase C: Effect on platelet-activating-factor-induced platelet functional responses. Biochem. J., 283, 159-164.
31. Cho,Y.S. et al. (2000) Extracellular protein kinase A as a cancer biomarker: Its expression by tumor cells and reversal by a myristate-lacking Cα and RIIb subunit overexpression. Proc. Natl Acad. Sci. USA, 97, 835-840.
32. Farazi,T.A. et al. (2001) The biology and enzymology of protein N-myr-istoylation. J. Biol. Chem., 276, 39501-39504.
33. Boutin,J.A. (1997) Myristoylation. Cell. Signal., 9, 15-35.
34. Folkman,J. et al. (1996) Blood vessel formation: What is its molecular basis? Cell, 87, 1153-1155.
35. Folkman,J. (2007) Angiogenesis: An organizing principle for drug discovery? Nat. Rev. Drug Discov., 6, 237-286.
36. Nakashima,S. (2002) Protein kinase Cα (PKCa): Regulation and biological function. J. Biochem., 132, 669-675.
37. Pollard,J.W. (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer, 4, 71-78.
38. Fukumura,D. et al. (2007) Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization. Microvasc. Res., 74, 72-84.
39. Netti,P.A. et al. (1995) Time-dependent behavior of interstitial fluid pressure in solid tumors: Implications for drug-delivery. Cancer Res., 55, 5451-5458.