Hyperglycosylated hCG in the management of quiescent and chemorefractory gestational trophoblastic diseases

Gynecologic Oncology

Volumn 116, Issue 1, 2010, Pages 3-9

  Cole, Laurence A ^a   Muller, Carolyn Y ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Choriocarcinoma; Gestational trophoblastic disease; hCG; Hyperglycosylated hCG; Minimally invasive disease

Indexed keywords

BEVACIZUMAB; BLEOMYCIN; CAPECITABINE; CARBOPLATIN; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; FOLINIC ACID; GEMCITABINE; HYPERGLYCOSYLATED CHORIONIC GONADOTROPIN; IFOSFAMIDE; METHOTREXATE; ONVOCIN; PACLITAXEL; TOPOTECAN; UNCLASSIFIED DRUG; VINCRISTINE SULFATE;

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER INVASION; CANCER RESISTANCE; DRUG TREATMENT FAILURE; FEMALE; GONADOTROPIN BLOOD LEVEL; HORMONE DETERMINATION; HORMONE URINE LEVEL; HUMAN; MAJOR CLINICAL STUDY; PRACTICE GUIDELINE; PRIORITY JOURNAL; REFERENCE VALUE; TREATMENT RESPONSE; TROPHOBLASTIC TUMOR; UNITED STATES;

ADULT; CHORIONIC GONADOTROPIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GESTATIONAL TROPHOBLASTIC NEOPLASMS; GLYCOSYLATION; HUMANS; MIDDLE AGED; PREGNANCY; REFERENCE VALUES; YOUNG ADULT;

EID: 70749159017     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.09.028     Document Type: Article

References (15)

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2. Cole L.A. Phantom hCG and phantom choriocarcinoma. Gynecol. Oncol. 325 329 (1998) 71
3. Cole L.A., and Butler S.A. False positive or phantom hCG result: a serious problem. Clin. Lab. Intl. 25 (2001) 9-14
4. Butler S.A., and Cole L.A. Falsely elevated hCG leading to unnecessary therapy. Obstet. Gynecol. 99 (2002) 515-516
5. Khanlian S.A., Smith H.O., and Cole L.A. Persistent low levels of hCG: a pre-malignant gestational trophoblastic disease. Am. J. Obstet. Gynecol. 188 (2003) 1254-1259
6. Cole L.A., and Sutton J.M. hCG tests in the management of gestational trophoblastic diseases. Clin. Obstet. Gynecol. 46 (2003) 533-540
7. LA Cole, CY Muller. New Approach to Treating Gestational Trophoblastic Neoplasms. Intl J Gynecol Cancer, in press 2009.
8. Cole L.A., Dai D., Leslie K.K., Butler S.A., and Kohorn E.I. Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG-regulated neoplasia. Gynecologic. Oncology. 102 (2006) 144-149
9. Cole L.A., Khanlian S.A., Riley J.M., and Butler S.A. Hyperglycosylated hCG (hCG-H) in gestational implantation, and in choriocarcinoma and testicular germ cell malignancy tumorigenesis. J. Reprod. Med. 51 (2006) 919-929
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11. Handshuh K., Guibourdenche J., Tsatsaris V., Guesnon M., Laurendeau I., Evain-Brion D., and Fournier T. Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-a. Endocrinol 148 (2007) 5011-5019
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13. Lei Z.M., Taylor D.D., Gercel-Taylor C., and Rao C.V. Human chorionic gonadotropin promotes tumorigenesis of choriocarcinoma JAR cells. Troph. Res. 13 (1999) 147-159
14. Cole L.A., Khanlian S.A., Sutton J.M., Davies S., and Stephens N. Hyperglycosylated hCG (invasive trophoblast antigen, ITA) a key antigen for early pregnancy detection. Clin. Biochem. 36 (2003) 647-655
15. LA Cole, SA Khanlian, The need for a quantitative urine hCG assay. Clin Biochem, in press 2009.