Betamethasone dose and formulation for induced lung maturation in fetal sheep

American Journal of Obstetrics and Gynecology

Volumn 201, Issue 6, 2009, Pages 611.e1-611.e7

  Jobe, Alan H ^a   Nitsos, Ilias ^b   Pillow, J Jane ^b   Polglase, Graeme R ^b   Kallapur, Suhas G ^a   Newnham, John P ^b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

corticosteroid; fetal therapy; preterm; respiratory distress syndrome; sheep

Indexed keywords

BETAMETHASONE; BETAMETHASONE ACETATE; BETAMETHASONE ACETATE PLUS BETAMETHASONE SODIUM PHOSPHATE; BETAMETHASONE SODIUM PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FORMULATION; EWE; FEMALE; FETAL THERAPY; FETUS; FETUS LUNG MATURATION; MALE; MATERNAL BLOOD; MATERNAL TREATMENT; NONHUMAN; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; SHEEP; SINGLE DRUG DOSE;

EID: 70749158243     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2009.07.014     Document Type: Article

References (24)

1. Roberts D., and Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 3 (2006) CD004454
2. Crowther C.A., and Harding J.E. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst Rev 3 (2007) CD003935
3. Murphy K.E., Hannah M.E., Willan A.R., et al. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 372 (2009) 2143-2151
4. Jobe A., Moss T.J.M., Nitsos I., Ikegami M., Kallapur S.G., and Newnham J.P. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. Am J Obstet Gynecol 97 (2007) 523-526
5. Brownfoot F.C., Crowther C.A., and Middleton P. Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 4 (2008) CD006764
6. Jobe A.H., Polk D., Ikegami M., et al. Lung responses to ultrasound-guided fetal treatments with corticosteroids in preterm lambs. J Appl Physiol 75 (1993) 2099-2105
7. Jobe A.H., Newnham J., Moss T.J., and Ikegami M. Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep. Am J Obstet Gynecol 188 (2003) 22-28
8. Berry L.M., Polk D.H., Ikegami M., Jobe A.H., Padbury J.F., and Ervin M.G. Preterm newborn lamb renal and cardiovascular responses after fetal or maternal antenatal betamethasone. Am J Physiol 272 (1997) R1972-R1979
9. Jobe A.H., Newnham J., Willet K., Sly P., and Ikegami M. Fetal versus maternal and gestational age effects of repetitive antenatal glucocorticoids. Pediatrics 102 (1998) 1116-1125
10. Jobe A.H., Wada N., Berry L.M., Ikegami M., and Ervin M.G. Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. Am J Obstet Gynecol 178 (1998) 880-885
11. Kutzler M.A., Ruane E.K., Coksaygan T., Vincent S.E., and Nathanielsz P.W. Effects of three courses of maternally administered dexamethasone at 0.7, 0.75, and 0.8 of gestation on prenatal and postnatal growth in sheep. Pediatrics 113 (2004) 313-319
12. Jobe A.H., and Soll R.F. Choice and dose of corticosteroid for antenatal treatments. Am J Obstet Gynecol 190 (2004) 878-881
13. Newnham J.P., Polk D.H., Kelly R.W., et al. Catecholamine response to ultrasonographically guided percutaneous blood sampling in fetal sheep. Am J Obstet Gynecol 171 (1994) 460-465
14. Samtani M.N., Lohle M., Grant A., Nathanielsz P.W., and Jusko W.J. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab Dispos 33 (2005) 1124-1130
15. Samtani M.N., Schwab M., Nathanielsz P.W., and Jusko W.J. Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. J Pharm Sci 93 (2004) 726-732
16. Notter R.H., Egan E.A., Kwong M.S., Holm B.A., and Shapiro D.L. Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique, and gestational age. Pediatr Res 19 (1985) 569-577
17. Jobe A.H., Newnham J.P., Willet K.E., et al. Endotoxin induced lung maturation in preterm lambs is not mediated by cortisol. Am J Respir Crit Care Med 162 (2000) 1656-1661
18. Bachurski C.J., Ross G.F., Ikegami M., Kramer B.W., and Jobe A.H. Intra-amniotic endotoxin increases pulmonary surfactant components and induces SP-B processing in fetal sheep. Am J Physiol Lung Cell Mol Physiol 280 (2001) L279-L285
19. Lee B.H., Stoll B.J., McDonald S.A., and Higgins R.D. Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics 117 (2006) 1503-1510
20. Feldman D.M., Carbone J., Belden L., Borgida A.F., and Herson V. Betamethasone vs dexamethasone for the prevention of morbidity in very-low-birthweight neonates. Am J Obstet Gynecol 197 (2007) 284.e1-284.e4
21. Elimian A., Garry D., Figueroa R., Spitzer A., Wiencek V., and Quirk J.G. Antenatal betamethasone compared with dexamethasone (betacode trial): a randomized controlled trial. Obstet Gynecol 110 (2007) 26-30
22. Guinn D.A., Atkinson M.W., Sullivan L., et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. JAMA 286 (2001) 1581-1587
23. Wapner R.J., Sorokin Y., Thom E.A., et al. Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 195 (2006) 633-642
24. Kurtzman J., Garite T., Clark R., et al., Network TOCR. Impact of a "rescue" course of antenatal corticosteroids (ACS): a multi-center randomized placebo controlled trial [abstract]. Am J Obstet Gynecol 200 (2008) 248.e1-248.e9