SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 1, 2010, Pages 67-69

A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors

Author keywords

Cholesterol absorption inhibitor; Ezetimibe; Synthesis

Indexed keywords

EID: 70749135704 PISSN: 10018417 EISSN: None Source Type: Journal
DOI: 10.1016/j.cclet.2009.08.009 Document Type: Article

Times cited : (2)

References (7)

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2
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- Wang Y.B., Zhao R., Zhang H.B., et al. Lett. Drug Des. Discov. 5 (2008) 39
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- Wang, Y.B.¹ Zhao, R.² Zhang, H.B.³

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- Kibler C.J., and Weissberger A. Org. Synth. 25 (1945) 7
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- Kibler, C.J.¹ Weissberger, A.²

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- Mitsunobu O. Synthesis 1 (1981) 1
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- Mitsunobu, O.¹

5
- 70749144162
- Synthesis of compound 6: To a solution of 5 (5.08 g, 13.55 mmol) and Ph3P (3.54 g, 13.55 mmol) in THF (40 mL) at 0 °C was added dropwise, DEAD (2.47 mL, 13.55 mmol, The solution was stirred for 8 h and then evaporated. The residue was purified on Si-gel to provide 1.58 g (32.7, of compound 6 as a white solid. Spectral data of compound 6: 1H NMR (CDCl3, 300 MHz, δ 7.26-6.88 (m, 8H, Ph, 4.64-4.63 (d, 1H, J, 2.1, CH2-CH-CH, 3.80 (s, 3H, Ph-OCH3, 3.66 (s, 3H, COOCH3, 3.14-3.08 (m, 1H, CH2-CH-CH, 2.61-2.48 (m, 2H, CH2-CH2-COO, 2.26-2.18 (m, 2H, CH2-CH2-COO, 13C NMR (CDCl3, 300 MHz, δ 167.8, 163.7, 160.5, 157.3, 133.8, 129.2, 127.5, 127.4, 127.4, 127.3, 127.2, 127.1, 118.4, 118.3, 115.9, 115.6, 115.4, 115.1, 114.6, 73.1, 61.0, 60.3, 55.3, 36.6, 24.9; IR KBr, cm-1, υ: 2986, 2917, 1740, 1610, 150
- + 380.

6
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- Browne M., Burnett D.A., Caplen M.A., et al. Tetrahedron Lett. 36 (1995) 2555
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- Browne, M.¹ Burnett, D.A.² Caplen, M.A.³

7
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- Salisbury B.G., Davis H.R., Burrier R.E., et al. Atherosclerosis 115 (1995) 45
- (1995) Atherosclerosis , vol.115 , pp. 45
- Salisbury, B.G.¹ Davis, H.R.² Burrier, R.E.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.