Gait disturbance associated with white matter changes: A gait analysis and blood flow study

NeuroImage

Volumn 49, Issue 2, 2010, Pages 1659-1666

  Iseki, Kazumi ^a,b   Hanakawa, Takashi ^c,d   Hashikawa, Kazuo ^e   Tomimoto, Hidekazu ^f   Nankaku, Manabu ^a   Yamauchi, Hiroshi ^a   Hallett, Mark ^b   Fukuyama, Hidenao ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e MINAMI OSAKA GENERAL HOSPITAL   (Japan)

^f MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Age related white matter changes; Cerebrovascular; Gait analysis; Gait disorder; SPECT; Vascular parkinsonism

Indexed keywords

AGE; AGED; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; BRAIN PERFUSION; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; GAIT DISORDER; HUMAN; MOTOR CORTEX; PREMOTOR CORTEX; PRIORITY JOURNAL; REST; SOMATOSENSORY CORTEX; THALAMOCORTICAL TRACT; THALAMUS; TREADMILL; VISUAL CORTEX; WALKING SPEED; WHITE MATTER;

AGED; AGED, 80 AND OVER; AGING; BIOMECHANICS; BRAIN; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; FEMALE; GAIT DISORDERS, NEUROLOGIC; HUMANS; MALE; NERVE FIBERS, MYELINATED; REST; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; WALKING;

EID: 70749132311     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2009.09.023     Document Type: Article

References (46)

1. Alexander M.P., Stuss D.T., Picton T., Shallice T., and Gillingham S. Regional frontal injuries cause distinct impairments in cognitive control. Neurology 68 (2007) 1515-1523
2. Altman D. In: Chapman, and Hall (Eds). Practical statistics for medical research (1999), CRC Press, London/Boca Raton 406-407
3. Audenaert K., Lahorte P., Brans B., van Laere K., Goethals I., van Heeringen K., and Dierckx R.A. The classical stroop interference task as a prefrontal activation probe: a validation study using 99Tcm-ECD brain SPECT. Nucl. Med. Commun. 22 (2001) 135-143
4. Baezner H., and Hennerici M. From trepidant abasia to motor network failure-gait disorders as a consequence of subcortical vascular encephalopathy (SVE): review of historical and contemporary concepts. J. Neurol. Sci. 229-230 (2005) 81-88
5. Baezner H., Oster M., Henning O., Cohen S., and Hennerici M.G. Amantadine increases gait steadiness in frontal gait disorder due to subcortical vascular encephalopathy: a double-blind randomized placebo-controlled trial based on quantitative gait analysis. Cerebrovasc. Dis. 11 (2001) 235-244
6. Baezner H., Blahak C., Poggesi A., Pantoni L., Inzitari D., Chabriat H., Erkinjuntti T., Fazekas F., Ferro J.M., Langhorne P., O'Brien J., Scheltens P., Visser M.C., Wahlund L.O., Waldemar G., Wallin A., and Hennerici M.G. Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70 (2008) 935-942
7. Baloh R.W., Yue Q., Socotch T.M., and Jacobson K.M. White matter lesions and disequilibrium in older people: I. Case-control comparison. Arch. Neurol. 52 (1995) 970-974
8. Baloh R.W., Ying S.H., and Jacobson K.M. A longitudinal study of gait and balance dysfunction in normal older people. Arch. Neurol. 60 (2003) 835-839
9. Bazner H., Oster M., Daffertshofer M., and Hennerici M. Assessment of gait in subcortical vascular encephalopathy by computerized analysis: a cross-sectional and longitudinal study. J. Neurol. 247 (2000) 841-849
10. Benson R.R., Guttmann C.R., Wei X., Warfield S.K., Hall C., Schmidt J.A., Kikinis R., and Wolfson L.I. Older people with impaired mobility have specific loci of periventricular abnormality on MRI. Neurology 58 (2002) 48-55
11. Blahak C., Baezner H., Pantoni L., Poggesi A., Chabriat H., Erkinjuntti T., Fazekas F., Ferro J.M., Langhorne P., O'Brien J., Visser M.C., Wahlund L.O., Waldemar G., Wallin A., Inzitari D., and Hennerici M.G. Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study. J. Neurol. Neurosurg. Psychiatry 80 (2009) 608-613
12. Briley D.P., Wasay M., Sergent S., and Thomas S. Cerebral white matter changes (leukoaraiosis), stroke, and gait disturbance. J. Am. Geriatr. Soc. 45 (1997) 1434-1438
13. Camicioli R., Moore M.M., Sexton G., Howieson D.B., and Kaye J.A. Age-related brain changes associated with motor function in healthy older people. J. Am. Geriatr. Soc. 47 (1999) 330-334
14. de Leeuw F.E., de Groot J.C., Achten E., Oudkerk M., Ramos L.M., Heijboer R., Hofman A., Jolles J., van Gijn J., and Breteler M.M. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J. Neurol. Neurosurg. Psychiatry 70 (2001) 9-14
15. DeLong M.R., and Wichmann T. Circuits and circuit disorders of the basal ganglia. Arch. Neurol. 64 (2007) 20-24
16. Ebersbach G., Sojer M., Valldeoriola F., Wissel J., Muller J., Tolosa E., and Poewe W. Comparative analysis of gait in Parkinson's disease, cerebellar ataxia and subcortical arteriosclerotic encephalopathy. Brain 122 Pt. 7 (1999) 1349-1355
17. Evans A.C., Kamber M., Collins D.L., and Macdonald D. An MRI-Based Probabilistic Atlas of Neuroanatomy (1994), Plenum, New York
18. Fazekas F., Chawluk J.B., Alavi A., Hurtig H.I., and Zimmerman R.A. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am. J. Roentgenol. 149 (1987) 351-356
19. Frenkel-Toledo S., Giladi N., Peretz C., Herman T., Gruendlinger L., and Hausdorff J.M. Treadmill walking as an external pacemaker to improve gait rhythm and stability in Parkinson's disease. Mov. Disord. 20 (2005) 1109-1114
20. Friston K.J., Ashburner J., Frith C.D., Poline J., Heather J.D., and Frackowiak R.S.J. Spatial registration and normalization of images. Hum. Brain Mapp. 3 (1995) 165-189
21. Fukuyama H., Ouchi Y., Matsuzaki S., Nagahama Y., Yamauchi H., Ogawa M., Kimura J., and Shibasaki H. Brain functional activity during gait in normal subjects: a SPECT study. Neurosci. Lett. 228 (1997) 183-186
22. Giladi N., Shabtai H., Simon E.S., Biran S., Tal J., and Korczyn A.D. Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat. Disord. 6 (2000) 165-170
23. Haaxma R., van Boxtel A., Brouwer W.H., Goeken L.N., Denier van der Gon J.J., Colebatch J.G., Martin A., Brooks D.J., Noth J., and Marsden C.D. Motor function in a patient with bilateral lesions of the globus pallidus. Mov. Disord. 10 (1995) 761-777
24. Hachinski V.C., Potter P., and Merskey H. Leuko-araiosis. Arch. Neurol. 44 (1987) 21-23
25. Hanakawa T. Neuroimaging of standing and walking: special emphasis on Parkinsonian gait. Parkinsonism Relat. Disord. 12 supplement 2 (2006) S70-S75
26. Hanakawa T., Fukuyama H., Katsumi Y., Honda M., and Shibasaki H. Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease. Ann. Neurol. 45 (1999) 329-336
27. Hanakawa T., Katsumi Y., Fukuyama H., Honda M., Hayashi T., Kimura J., and Shibasaki H. Mechanisms underlying gait disturbance in Parkinson's disease: a single photon emission computed tomography study. Brain 122 Pt. 7 (1999) 1271-1282
28. Inao S., Tadokoro M., Nishino M., Mizutani N., Terada K., Bundo M., Kuchiwaki H., and Yoshida J. Neural activation of the brain with hemodynamic insufficiency. J. Cereb. Blood Flow Metab. 18 (1998) 960-967
29. Inzitari M., Pozzi C., Rinaldi L.A., Masotti G., Marchionni N., and Di Bari M. Cognitive and functional impairment in hypertensive brain microangiopathy. J. Neurol. Sci. 257 (2007) 166-173
30. Iseki K., Hanakawa T., Shinozaki J., Nankaku M., and Fukuyama H. Neural mechanisms involved in mental imagery and observation of gait. NeuroImage 41 (2008) 1021-1031
31. Jankovic J., Nutt J.G., and Sudarsky L. Classification, diagnosis, and etiology of gait disorders. Adv. Neurol. 87 (2001) 119-133
32. Jellinger K.A. Understanding the pathology of vascular cognitive impairment. J. Neurol. Sci. 229-230 (2005) 57-63
33. Labadie E.L., Awerbuch G.I., Hamilton R.H., and Rapesak S.Z. Falling and postural deficits due to acute unilateral basal ganglia lesions. Arch. Neurol. 46 (1989) 492-496
34. Landis J.R., and Koch G.G. The measurement of observer agreement for categorical data. Biometrics 33 (1977) 159-174
35. Masdeu J.C., and Gorelick P.B. Thalamic astasia: inability to stand after unilateral thalamic lesions. Ann. Neurol. 23 (1988) 596-603
36. Masdeu J.C., Wolfson L., Lantos G., Tobin J.N., Grober E., Whipple R., and Amerman P. Brain white-matter changes in the elderly prone to falling. Arch. Neurol. 46 (1989) 1292-1296
37. Miyai I., Yagura H., Hatakenaka M., Oda I., Konishi I., and Kubota K. Longitudinal optical imaging study for locomotor recovery after stroke. Stroke 34 (2003) 2866-2870
38. Nadeau S.E. Gait apraxia: further clues to localization. Eur. Neurol. 58 (2007) 142-145
39. Oku N., Matsumoto M., Hashikawa K., Moriwaki H., Okazaki Y., Seike Y., Handa N., Uehara T., Kamada T., and Nishimura T. Carbon dioxide reactivity by consecutive technetium-99m-HMPAO SPECT in patients with a chronically obstructed major cerebral artery. J. Nucl. Med. 35 (1994) 32-40
40. Ouchi Y., Kanno T., Okada H., Yoshikawa E., Futatsubashi M., Nobezawa S., Torizuka T., and Tanaka K. Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. Brain 124 (2001) 784-792
41. Rabitsch W., Brugger S.A., Pirker W., Baumgartner C., Reiter E., Keil F., Prayer D., Hoecker P., Lechner K., Kalhs P., and Greinix H.T. Symmetrical necrosis of globus pallidus with severe gait disturbance in a patient with myelodysplastic syndrome given allogeneic marrow transplantation. Ann. Hematol. 75 (1997) 235-237
42. Rektor I., Rektorova I., and Kubova D. Vascular parkinsonism - an update. J. Neurol. Sci. 248 (2006) 185-191
43. Rosano C., Brach J., Longstreth W.T., and Newman A.B. Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adults. Neuroepidemiology 26 (2006) 52-60
44. Starr J.M., Leaper S.A., Murray A.D., Lemmon H.A., Staff R.T., Deary I.J., and Whalley L.J. Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed. J. Neurol. Neurosurg. Psychiatry 74 (2003) 94-98
45. Thompson P.D., and Marsden C.D. Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger's disease. Mov. Disord. 2 (1987) 1-8
46. Whitman G.T., Tang Y., Lin A., and Baloh R.W. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology 57 (2001) 990-994