메뉴 건너뛰기




Volumn 21, Issue 6, 2009, Pages 355-362

Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders

Author keywords

Autoimmunity; Genome wide association; Inflammatory bowel disease; Type 1 diabetes

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CATHEPSIN H; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN CLASS 2; INSULIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; INTERLEUKIN 23 RECEPTOR; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PROTEIN KINASE C THETA;

EID: 70749128610     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2009.06.001     Document Type: Review
Times cited : (20)

References (129)
  • 1
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller K.E., Pearce C.L., Pike M., Lander E.S., and Hirschhorn J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics 33 2 (2003) 177-182
    • (2003) Nature Genetics , vol.33 , Issue.2 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 2
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • Hirschhorn J.N., and Daly M.J. Genome-wide association studies for common diseases and complex traits. Nature Reviews 6 2 (2005) 95-108
    • (2005) Nature Reviews , vol.6 , Issue.2 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 3
    • 2642583283 scopus 로고    scopus 로고
    • Mapping complex disease loci in whole-genome association studies
    • Carlson C.S., Eberle M.A., Kruglyak L., and Nickerson D.A. Mapping complex disease loci in whole-genome association studies. Nature 429 6990 (2004) 446-452
    • (2004) Nature , vol.429 , Issue.6990 , pp. 446-452
    • Carlson, C.S.1    Eberle, M.A.2    Kruglyak, L.3    Nickerson, D.A.4
  • 4
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Project. Nature 426 6968 (2003) 789-796
    • (2003) Nature , vol.426 , Issue.6968 , pp. 789-796
  • 5
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • A haplotype map of the human genome. Nature 437 7063 (2005) 1299-1320
    • (2005) Nature , vol.437 , Issue.7063 , pp. 1299-1320
  • 6
    • 31344476038 scopus 로고    scopus 로고
    • Whole-genome genotyping with the single-base extension assay
    • Steemers F.J., Chang W., Lee G., et al. Whole-genome genotyping with the single-base extension assay. Nature Methods 3 1 (2006) 31-33
    • (2006) Nature Methods , vol.3 , Issue.1 , pp. 31-33
    • Steemers, F.J.1    Chang, W.2    Lee, G.3
  • 7
    • 18144425478 scopus 로고    scopus 로고
    • A genome-wide scalable SNP genotyping assay using microarray technology
    • Gunderson K.L., Steemers F.J., Lee G., Mendoza L.G., and Chee M.S. A genome-wide scalable SNP genotyping assay using microarray technology. Nature Genetics 37 5 (2005) 549-554
    • (2005) Nature Genetics , vol.37 , Issue.5 , pp. 549-554
    • Gunderson, K.L.1    Steemers, F.J.2    Lee, G.3    Mendoza, L.G.4    Chee, M.S.5
  • 8
    • 27144472560 scopus 로고    scopus 로고
    • A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility
    • Reich D., Patterson N., De Jager P.L., et al. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nature Genetics 37 10 (2005) 1113-1118
    • (2005) Nature Genetics , vol.37 , Issue.10 , pp. 1113-1118
    • Reich, D.1    Patterson, N.2    De Jager, P.L.3
  • 9
    • 25844510235 scopus 로고    scopus 로고
    • Shaking the tree: mapping complex disease genes with linkage disequilibrium
    • Palmer L.J., and Cardon L.R. Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 366 9492 (2005) 1223-1234
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1223-1234
    • Palmer, L.J.1    Cardon, L.R.2
  • 10
    • 26244444318 scopus 로고    scopus 로고
    • What makes a good genetic association study?
    • Hattersley A.T., and McCarthy M.I. What makes a good genetic association study?. Lancet 366 9493 (2005) 1315-1323
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1315-1323
    • Hattersley, A.T.1    McCarthy, M.I.2
  • 11
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • Cardon L.R., and Bell J.I. Association study designs for complex diseases. Nature Reviews 2 2 (2001) 91-99
    • (2001) Nature Reviews , vol.2 , Issue.2 , pp. 91-99
    • Cardon, L.R.1    Bell, J.I.2
  • 12
    • 25144501575 scopus 로고    scopus 로고
    • Genetic association studies
    • Cordell H.J., and Clayton D.G. Genetic association studies. Lancet 366 9491 (2005) 1121-1131
    • (2005) Lancet , vol.366 , Issue.9491 , pp. 1121-1131
    • Cordell, H.J.1    Clayton, D.G.2
  • 13
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein R.J., Zeiss C., Chew E.Y., et al. Complement factor H polymorphism in age-related macular degeneration. Science 308 5720 (2005) 385-389
    • (2005) Science , vol.308 , Issue.5720 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3
  • 14
    • 17244379811 scopus 로고    scopus 로고
    • Complement factor H polymorphism and age-related macular degeneration
    • Edwards A.O., Ritter III R., Abel K.J., et al. Complement factor H polymorphism and age-related macular degeneration. Science 308 5720 (2005) 421-424
    • (2005) Science , vol.308 , Issue.5720 , pp. 421-424
    • Edwards, A.O.1    Ritter III, R.2    Abel, K.J.3
  • 15
    • 20244388812 scopus 로고    scopus 로고
    • Complement factor H variant increases the risk of age-related macular degeneration
    • Haines J.L., Hauser M.A., Schmidt S., et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 308 5720 (2005) 419-421
    • (2005) Science , vol.308 , Issue.5720 , pp. 419-421
    • Haines, J.L.1    Hauser, M.A.2    Schmidt, S.3
  • 16
    • 34548694283 scopus 로고    scopus 로고
    • Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma
    • Thorleifsson G., Magnusson K.P., Sulem P., et al. Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science 317 5843 (2007) 1397-1400
    • (2007) Science , vol.317 , Issue.5843 , pp. 1397-1400
    • Thorleifsson, G.1    Magnusson, K.P.2    Sulem, P.3
  • 17
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R., Rocheleau G., Rung J., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 7130 (2007) 881-885
    • (2007) Nature , vol.445 , Issue.7130 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 18
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case-Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 447 7145 (2007) 661-678
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
    • Wellcome Trust Case-Control Consortium1
  • 19
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R., Voight B.F., Lyssenko V., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 5829 (2007) 1331-1336
    • (2007) Science , vol.316 , Issue.5829 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 20
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E., Weedon M.N., Lindgren C.M., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 5829 (2007) 1336-1341
    • (2007) Science , vol.316 , Issue.5829 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 21
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott L.J., Mohlke K.L., Bonnycastle L.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 5829 (2007) 1341-1345
    • (2007) Science , vol.316 , Issue.5829 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 22
    • 34249828965 scopus 로고    scopus 로고
    • A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    • Steinthorsdottir V., Thorleifsson G., Reynisdottir I., et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nature Genetics 39 6 (2007) 770-775
    • (2007) Nature Genetics , vol.39 , Issue.6 , pp. 770-775
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 23
    • 34547755055 scopus 로고    scopus 로고
    • Type 2 diabetes whole-genome association study in four populations: the DiaGen Consortium
    • Salonen J.T., Uimari P., Aalto J.M., et al. Type 2 diabetes whole-genome association study in four populations: the DiaGen Consortium. American Journal of Human Genetics 81 2 (2007) 338-345
    • (2007) American Journal of Human Genetics , vol.81 , Issue.2 , pp. 338-345
    • Salonen, J.T.1    Uimari, P.2    Aalto, J.M.3
  • 24
    • 36849035803 scopus 로고    scopus 로고
    • A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets
    • Florez J.C., Manning A.K., Dupuis J., et al. A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes 56 12 (2007) 3063-3074
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3063-3074
    • Florez, J.C.1    Manning, A.K.2    Dupuis, J.3
  • 25
    • 36849029819 scopus 로고    scopus 로고
    • A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array
    • Hanson R.L., Bogardus C., Duggan D., et al. A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes 56 12 (2007) 3045-3052
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3045-3052
    • Hanson, R.L.1    Bogardus, C.2    Duggan, D.3
  • 26
    • 36849023376 scopus 로고    scopus 로고
    • Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    • Rampersaud E., Damcott C.M., Fu M., et al. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes 56 12 (2007) 3053-3062
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3053-3062
    • Rampersaud, E.1    Damcott, C.M.2    Fu, M.3
  • 27
    • 36849081967 scopus 로고    scopus 로고
    • Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies
    • Hayes M.G., Pluzhnikov A., Miyake K., et al. Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes 56 12 (2007) 3033-3044
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3033-3044
    • Hayes, M.G.1    Pluzhnikov, A.2    Miyake, K.3
  • 28
    • 34250010480 scopus 로고    scopus 로고
    • A common variant on chromosome 9p21 affects the risk of myocardial infarction
    • Helgadottir A., Thorleifsson G., Manolescu A., et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316 5830 (2007) 1491-1493
    • (2007) Science , vol.316 , Issue.5830 , pp. 1491-1493
    • Helgadottir, A.1    Thorleifsson, G.2    Manolescu, A.3
  • 29
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • McPherson R., Pertsemlidis A., Kavaslar N., et al. A common allele on chromosome 9 associated with coronary heart disease. Science 316 5830 (2007) 1488-1491
    • (2007) Science , vol.316 , Issue.5830 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3
  • 30
    • 34447515621 scopus 로고    scopus 로고
    • Variants conferring risk of atrial fibrillation on chromosome 4q25
    • Gudbjartsson D.F., Arnar D.O., Helgadottir A., et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 448 7151 (2007) 353-357
    • (2007) Nature , vol.448 , Issue.7151 , pp. 353-357
    • Gudbjartsson, D.F.1    Arnar, D.O.2    Helgadottir, A.3
  • 31
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S., Melander O., Guiducci C., et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nature Genetics 40 2 (2008) 189-197
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3
  • 32
    • 38649125868 scopus 로고    scopus 로고
    • Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    • Willer C.J., Sanna S., Jackson A.U., et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nature Genetics 40 2 (2008) 161-169
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 161-169
    • Willer, C.J.1    Sanna, S.2    Jackson, A.U.3
  • 33
    • 38649084407 scopus 로고    scopus 로고
    • Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    • Kooner J.S., Chambers J.C., Aguilar-Salinas C.A., et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nature Genetics 40 2 (2008) 149-151
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 149-151
    • Kooner, J.S.1    Chambers, J.C.2    Aguilar-Salinas, C.A.3
  • 34
    • 34247563453 scopus 로고    scopus 로고
    • Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    • Gudmundsson J., Sulem P., Manolescu A., et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nature Genetics 39 5 (2007) 631-637
    • (2007) Nature Genetics , vol.39 , Issue.5 , pp. 631-637
    • Gudmundsson, J.1    Sulem, P.2    Manolescu, A.3
  • 35
    • 34247548755 scopus 로고    scopus 로고
    • Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    • Yeager M., Orr N., Hayes R.B., et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nature Genetics 39 5 (2007) 645-649
    • (2007) Nature Genetics , vol.39 , Issue.5 , pp. 645-649
    • Yeager, M.1    Orr, N.2    Hayes, R.B.3
  • 36
    • 34247482327 scopus 로고    scopus 로고
    • Multiple regions within 8q24 independently affect risk for prostate cancer
    • Haiman C.A., Patterson N., Freedman M.L., et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nature Genetics 39 5 (2007) 638-644
    • (2007) Nature Genetics , vol.39 , Issue.5 , pp. 638-644
    • Haiman, C.A.1    Patterson, N.2    Freedman, M.L.3
  • 37
    • 34547498546 scopus 로고    scopus 로고
    • A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
    • Tomlinson I., Webb E., Carvajal-Carmona L., et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nature Genetics 39 8 (2007) 984-988
    • (2007) Nature Genetics , vol.39 , Issue.8 , pp. 984-988
    • Tomlinson, I.1    Webb, E.2    Carvajal-Carmona, L.3
  • 38
    • 34250006413 scopus 로고    scopus 로고
    • Genome-wide association study identifies novel breast cancer susceptibility loci
    • Easton D.F., Pooley K.A., Dunning A.M., et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447 7148 (2007) 1087-1093
    • (2007) Nature , vol.447 , Issue.7148 , pp. 1087-1093
    • Easton, D.F.1    Pooley, K.A.2    Dunning, A.M.3
  • 39
    • 34250002140 scopus 로고    scopus 로고
    • Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer
    • Stacey S.N., Manolescu A., Sulem P., et al. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nature Genetics 39 7 (2007) 865-869
    • (2007) Nature Genetics , vol.39 , Issue.7 , pp. 865-869
    • Stacey, S.N.1    Manolescu, A.2    Sulem, P.3
  • 40
    • 45149123645 scopus 로고    scopus 로고
    • Chromosome 6p22 locus associated with clinically aggressive neuroblastoma
    • Maris J.M., Mosse Y.P., Bradfield J.P., et al. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. The New England Journal of Medicine 358 24 (2008) 2585-2593
    • (2008) The New England Journal of Medicine , vol.358 , Issue.24 , pp. 2585-2593
    • Maris, J.M.1    Mosse, Y.P.2    Bradfield, J.P.3
  • 41
    • 67349112868 scopus 로고    scopus 로고
    • Common genetic variants on 5p14.1 associate with autism spectrum disorders
    • Wang K., Zhang H., Ma D., et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009)
    • (2009) Nature
    • Wang, K.1    Zhang, H.2    Ma, D.3
  • 42
    • 0034635768 scopus 로고    scopus 로고
    • Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group
    • EURODIAB ACE Study Group
    • EURODIAB ACE Study Group. Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group. Lancet 355 9207 (2000) 873-876
    • (2000) Lancet , vol.355 , Issue.9207 , pp. 873-876
  • 43
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends
    • Onkamo P., Vaananen S., Karvonen M., and Tuomilehto J. Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends. Diabetologia 42 12 (1999) 1395-1403
    • (1999) Diabetologia , vol.42 , Issue.12 , pp. 1395-1403
    • Onkamo, P.1    Vaananen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 44
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • Bell G.I., Horita S., and Karam J.H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33 2 (1984) 176-183
    • (1984) Diabetes , vol.33 , Issue.2 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 45
    • 0028871202 scopus 로고
    • Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
    • Bennett S.T., Lucassen A.M., Gough S.C., et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genetics 9 3 (1995) 284-292
    • (1995) Nature Genetics , vol.9 , Issue.3 , pp. 284-292
    • Bennett, S.T.1    Lucassen, A.M.2    Gough, S.C.3
  • 46
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P., Bennett S.T., Todd J.A., et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nature Genetics 15 3 (1997) 289-292
    • (1997) Nature Genetics , vol.15 , Issue.3 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3
  • 47
    • 3042698329 scopus 로고    scopus 로고
    • Remapping the insulin gene/IDDM2 locus in type 1 diabetes
    • Barratt B.J., Payne F., Lowe C.E., et al. Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes 53 7 (2004) 1884-1889
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1884-1889
    • Barratt, B.J.1    Payne, F.2    Lowe, C.E.3
  • 48
    • 0034139830 scopus 로고    scopus 로고
    • CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity?
    • Kristiansen O.P., Larsen Z.M., and Pociot F. CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity?. Genes and Immunity 1 3 (2000) 170-184
    • (2000) Genes and Immunity , vol.1 , Issue.3 , pp. 170-184
    • Kristiansen, O.P.1    Larsen, Z.M.2    Pociot, F.3
  • 49
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H., Howson J.M., Esposito L., et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423 6939 (2003) 506-511
    • (2003) Nature , vol.423 , Issue.6939 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3
  • 50
    • 10344224011 scopus 로고    scopus 로고
    • Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block
    • Anjos S.M., Tessier M.C., and Polychronakos C. Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block. The Journal of Clinical Endocrinology and Metabolism 89 12 (2004) 6257-6265
    • (2004) The Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6257-6265
    • Anjos, S.M.1    Tessier, M.C.2    Polychronakos, C.3
  • 51
    • 8944259914 scopus 로고    scopus 로고
    • The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
    • Nistico L., Buzzetti R., Pritchard L.E., et al. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Human Molecular Genetics 5 7 (1996) 1075-1080
    • (1996) Human Molecular Genetics , vol.5 , Issue.7 , pp. 1075-1080
    • Nistico, L.1    Buzzetti, R.2    Pritchard, L.E.3
  • 52
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N., Musumeci L., Alonso A., et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nature Genetics 36 4 (2004) 337-338
    • (2004) Nature Genetics , vol.36 , Issue.4 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3
  • 53
    • 7044253358 scopus 로고    scopus 로고
    • Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    • Smyth D., Cooper J.D., Collins J.E., et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53 11 (2004) 3020-3023
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 3020-3023
    • Smyth, D.1    Cooper, J.D.2    Collins, J.E.3
  • 54
    • 20244373351 scopus 로고    scopus 로고
    • Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    • Vella A., Cooper J.D., Lowe C.E., et al. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. American Journal of Human Genetics 76 5 (2005) 773-779
    • (2005) American Journal of Human Genetics , vol.76 , Issue.5 , pp. 773-779
    • Vella, A.1    Cooper, J.D.2    Lowe, C.E.3
  • 55
    • 34047118563 scopus 로고    scopus 로고
    • Toward further mapping of the association between the IL2RA locus and type 1 diabetes
    • Qu H.Q., Montpetit A., Ge B., Hudson T.J., and Polychronakos C. Toward further mapping of the association between the IL2RA locus and type 1 diabetes. Diabetes 56 4 (2007) 1174-1176
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1174-1176
    • Qu, H.Q.1    Montpetit, A.2    Ge, B.3    Hudson, T.J.4    Polychronakos, C.5
  • 56
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe C.E., Cooper J.D., Brusko T., et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nature Genetics 39 9 (2007) 1074-1082
    • (2007) Nature Genetics , vol.39 , Issue.9 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3
  • 57
    • 3543046736 scopus 로고    scopus 로고
    • A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    • Guo D., Li M., Zhang Y., et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nature Genetics 36 8 (2004) 837-841
    • (2004) Nature Genetics , vol.36 , Issue.8 , pp. 837-841
    • Guo, D.1    Li, M.2    Zhang, Y.3
  • 58
    • 0036828891 scopus 로고    scopus 로고
    • Association of IL4R haplotypes with type 1 diabetes
    • Mirel D.B., Valdes A.M., Lazzeroni L.C., et al. Association of IL4R haplotypes with type 1 diabetes. Diabetes 51 11 (2002) 3336-3341
    • (2002) Diabetes , vol.51 , Issue.11 , pp. 3336-3341
    • Mirel, D.B.1    Valdes, A.M.2    Lazzeroni, L.C.3
  • 59
    • 17444409580 scopus 로고    scopus 로고
    • Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity
    • Biason-Lauber A., Boehm B., Lang-Muritano M., et al. Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48 5 (2005) 900-905
    • (2005) Diabetologia , vol.48 , Issue.5 , pp. 900-905
    • Biason-Lauber, A.1    Boehm, B.2    Lang-Muritano, M.3
  • 60
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth D.J., Cooper J.D., Bailey R., et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nature Genetics 38 6 (2006) 617-619
    • (2006) Nature Genetics , vol.38 , Issue.6 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3
  • 61
    • 31444451575 scopus 로고    scopus 로고
    • Environmental triggers and determinants of type 1 diabetes
    • Knip M., Veijola R., Virtanen S.M., et al. Environmental triggers and determinants of type 1 diabetes. Diabetes 54 Suppl. 2 (2005) S125-S136
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Knip, M.1    Veijola, R.2    Virtanen, S.M.3
  • 62
    • 34547621758 scopus 로고    scopus 로고
    • A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    • Hakonarson H., Grant S.F., Bradfield J.P., et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448 7153 (2007) 591-594
    • (2007) Nature , vol.448 , Issue.7153 , pp. 591-594
    • Hakonarson, H.1    Grant, S.F.2    Bradfield, J.P.3
  • 64
    • 20544436120 scopus 로고    scopus 로고
    • Levels of complexity in pathogen recognition by C-type lectins
    • Cambi A., and Figdor C.G. Levels of complexity in pathogen recognition by C-type lectins. Current Opinion in Immunology 17 4 (2005) 345-351
    • (2005) Current Opinion in Immunology , vol.17 , Issue.4 , pp. 345-351
    • Cambi, A.1    Figdor, C.G.2
  • 65
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd J.A., Walker N.M., Cooper J.D., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics 39 7 (2007) 857-864
    • (2007) Nature Genetics , vol.39 , Issue.7 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3
  • 66
    • 42449094966 scopus 로고    scopus 로고
    • A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    • Hakonarson H., Qu H.Q., Bradfield J.P., et al. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes 57 4 (2008) 1143-1146
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1143-1146
    • Hakonarson, H.1    Qu, H.Q.2    Bradfield, J.P.3
  • 67
    • 70749126385 scopus 로고    scopus 로고
    • Follow up analysis of genome-wide association data identifies novel loci for type 1 diabetes
    • Grant S.F., Qu H.Q., Bradfield J.P., et al. Follow up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes (2008)
    • (2008) Diabetes
    • Grant, S.F.1    Qu, H.Q.2    Bradfield, J.P.3
  • 68
    • 58149090841 scopus 로고    scopus 로고
    • A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    • Concannon P., Onengut-Gumuscu S., Todd J.A., et al. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes 57 10 (2008) 2858-2861
    • (2008) Diabetes , vol.57 , Issue.10 , pp. 2858-2861
    • Concannon, P.1    Onengut-Gumuscu, S.2    Todd, J.A.3
  • 69
    • 56749183605 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    • Cooper J.D., Smyth D.J., Smiles A.M., et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nature Genetics 40 12 (2008) 1399-1401
    • (2008) Nature Genetics , vol.40 , Issue.12 , pp. 1399-1401
    • Cooper, J.D.1    Smyth, D.J.2    Smiles, A.M.3
  • 70
    • 33745827044 scopus 로고    scopus 로고
    • Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes
    • Mueller P.W., Rogus J.J., Cleary P.A., et al. Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. Journal of the American Society of Nephrology 17 7 (2006) 1782-1790
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.7 , pp. 1782-1790
    • Mueller, P.W.1    Rogus, J.J.2    Cleary, P.A.3
  • 71
    • 34548340684 scopus 로고    scopus 로고
    • New models of collaboration in genome-wide association studies: the Genetic Association Information Network
    • Manolio T.A., Rodriguez L.L., Brooks L., et al. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nature Genetics 39 9 (2007) 1045-1051
    • (2007) Nature Genetics , vol.39 , Issue.9 , pp. 1045-1051
    • Manolio, T.A.1    Rodriguez, L.L.2    Brooks, L.3
  • 76
    • 0037308263 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Bonen D.K., and Cho J.H. The genetics of inflammatory bowel disease. Gastroenterology 124 2 (2003) 521-536
    • (2003) Gastroenterology , vol.124 , Issue.2 , pp. 521-536
    • Bonen, D.K.1    Cho, J.H.2
  • 77
    • 0142021798 scopus 로고    scopus 로고
    • Update on the genetics of inflammatory bowel disease
    • Duerr R.H. Update on the genetics of inflammatory bowel disease. Journal of Clinical Gastroenterology 37 5 (2003) 358-367
    • (2003) Journal of Clinical Gastroenterology , vol.37 , Issue.5 , pp. 358-367
    • Duerr, R.H.1
  • 79
    • 0030042271 scopus 로고    scopus 로고
    • Genetics versus environment in inflammatory bowel disease: results of a British twin study
    • Thompson N.P., Driscoll R., Pounder R.E., and Wakefield A.J. Genetics versus environment in inflammatory bowel disease: results of a British twin study. BMJ 312 7023 (1996) 95-96
    • (1996) BMJ , vol.312 , Issue.7023 , pp. 95-96
    • Thompson, N.P.1    Driscoll, R.2    Pounder, R.E.3    Wakefield, A.J.4
  • 80
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • Tysk C., Lindberg E., Jarnerot G., and Floderus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29 7 (1988) 990-996
    • (1988) Gut , vol.29 , Issue.7 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3    Floderus-Myrhed, B.4
  • 81
    • 33646020997 scopus 로고    scopus 로고
    • New genes in inflammatory bowel disease: lessons for complex diseases?
    • Gaya D.R., Russell R.K., Nimmo E.R., and Satsangi J. New genes in inflammatory bowel disease: lessons for complex diseases?. Lancet 367 9518 (2006) 1271-1284
    • (2006) Lancet , vol.367 , Issue.9518 , pp. 1271-1284
    • Gaya, D.R.1    Russell, R.K.2    Nimmo, E.R.3    Satsangi, J.4
  • 82
    • 0038620498 scopus 로고    scopus 로고
    • Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics
    • Halfvarson J., Bodin L., Tysk C., Lindberg E., and Jarnerot G. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology 124 7 (2003) 1767-1773
    • (2003) Gastroenterology , vol.124 , Issue.7 , pp. 1767-1773
    • Halfvarson, J.1    Bodin, L.2    Tysk, C.3    Lindberg, E.4    Jarnerot, G.5
  • 83
    • 0031011057 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Satsangi J., Jewell D.P., and Bell J.I. The genetics of inflammatory bowel disease. Gut 40 5 (1997) 572-574
    • (1997) Gut , vol.40 , Issue.5 , pp. 572-574
    • Satsangi, J.1    Jewell, D.P.2    Bell, J.I.3
  • 84
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J.P., Chamaillard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 6837 (2001) 599-603
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 85
    • 0035978533 scopus 로고    scopus 로고
    • A frame shift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y., Bonen D.K., Inohara N., et al. A frame shift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 6837 (2001) 603-606
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 86
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe J., Cuthbert A., Croucher P.J., et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357 9272 (2001) 1925-1928
    • (2001) Lancet , vol.357 , Issue.9272 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.3
  • 87
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • Rioux J.D., Daly M.J., Silverberg M.S., et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature Genetics 29 2 (2001) 223-228
    • (2001) Nature Genetics , vol.29 , Issue.2 , pp. 223-228
    • Rioux, J.D.1    Daly, M.J.2    Silverberg, M.S.3
  • 88
    • 0037383554 scopus 로고    scopus 로고
    • Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    • Mirza M.M., Fisher S.A., King K., et al. Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. American Journal of Human Genetics 72 4 (2003) 1018-1022
    • (2003) American Journal of Human Genetics , vol.72 , Issue.4 , pp. 1018-1022
    • Mirza, M.M.1    Fisher, S.A.2    King, K.3
  • 89
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn disease
    • Peltekova V.D., Wintle R.F., Rubin L.A., et al. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nature Genetics 36 5 (2004) 471-475
    • (2004) Nature Genetics , vol.36 , Issue.5 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3
  • 90
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R.H., Taylor K.D., Brant S.R., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 5804 (2006) 1461-1463
    • (2006) Science , vol.314 , Issue.5804 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 91
    • 34547436749 scopus 로고    scopus 로고
    • Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease
    • Baldassano R.N., Bradfield J.P., Monos D.S., et al. Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. Clinical Gastroenterology and Hepatology 5 8 (2007) 972-976
    • (2007) Clinical Gastroenterology and Hepatology , vol.5 , Issue.8 , pp. 972-976
    • Baldassano, R.N.1    Bradfield, J.P.2    Monos, D.S.3
  • 92
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux J.D., Xavier R.J., Taylor K.D., et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature Genetics 39 5 (2007) 596-604
    • (2007) Nature Genetics , vol.39 , Issue.5 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3
  • 93
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J., Franke A., Rosenstiel P., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nature Genetics 39 2 (2007) 207-211
    • (2007) Nature Genetics , vol.39 , Issue.2 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 95
  • 96
    • 0033358425 scopus 로고    scopus 로고
    • A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
    • Hampe J., Schreiber S., Shaw S.H., et al. A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. American Journal of Human Genetics 64 3 (1999) 808-816
    • (1999) American Journal of Human Genetics , vol.64 , Issue.3 , pp. 808-816
    • Hampe, J.1    Schreiber, S.2    Shaw, S.H.3
  • 97
    • 0242606876 scopus 로고    scopus 로고
    • Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci
    • Shaw S.H., Hampe J., White R., et al. Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci. Human Genetics 113 6 (2003) 514-521
    • (2003) Human Genetics , vol.113 , Issue.6 , pp. 514-521
    • Shaw, S.H.1    Hampe, J.2    White, R.3
  • 98
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M., Barrett J.C., Prescott N.J., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics 39 7 (2007) 830-832
    • (2007) Nature Genetics , vol.39 , Issue.7 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 99
    • 34547211759 scopus 로고    scopus 로고
    • Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease
    • Baldassano R.N., Bradfield J.P., Monos D.S., et al. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut 56 8 (2007) 1171-1173
    • (2007) Gut , vol.56 , Issue.8 , pp. 1171-1173
    • Baldassano, R.N.1    Bradfield, J.P.2    Monos, D.S.3
  • 100
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett J.C., Hansoul S., Nicolae D.L., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics 40 8 (2008) 955-962
    • (2008) Nature Genetics , vol.40 , Issue.8 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 101
    • 44349173654 scopus 로고    scopus 로고
    • Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
    • Franke A., Balschun T., Karlsen T.H., et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nature Genetics 40 6 (2008) 713-715
    • (2008) Nature Genetics , vol.40 , Issue.6 , pp. 713-715
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 102
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher S.A., Tremelling M., Anderson C.A., et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40 6 (2008) 710-712
    • (2008) Nature Genetics , vol.40 , Issue.6 , pp. 710-712
    • Fisher, S.A.1    Tremelling, M.2    Anderson, C.A.3
  • 103
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A., Balschun T., Karlsen T.H., et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nature Genetics 40 11 (2008) 1319-1323
    • (2008) Nature Genetics , vol.40 , Issue.11 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 104
    • 59149087627 scopus 로고    scopus 로고
    • Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    • Silverberg M.S., Cho J.H., Rioux J.D., et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nature Genetics (2009)
    • (2009) Nature Genetics
    • Silverberg, M.S.1    Cho, J.H.2    Rioux, J.D.3
  • 105
    • 53049110159 scopus 로고    scopus 로고
    • Natural history of pediatric Crohn's disease: a population-based cohort study
    • Vernier-Massouille G., Mamadou B., Julia S., et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology 135 4 (2008) 1106-1113
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1106-1113
    • Vernier-Massouille, G.1    Mamadou, B.2    Julia, S.3
  • 106
    • 53049083199 scopus 로고    scopus 로고
    • Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease
    • Van Limbergen J., Russell R.K., Drummond H.E., et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 135 4 (2008) 1114-1122
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1114-1122
    • Van Limbergen, J.1    Russell, R.K.2    Drummond, H.E.3
  • 107
    • 52949091918 scopus 로고    scopus 로고
    • Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
    • Kugathasan S., Baldassano R.N., Bradfield J.P., et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nature Genetics 40 10 (2008) 1211-1215
    • (2008) Nature Genetics , vol.40 , Issue.10 , pp. 1211-1215
    • Kugathasan, S.1    Baldassano, R.N.2    Bradfield, J.P.3
  • 108
    • 33747415823 scopus 로고    scopus 로고
    • Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells
    • Fayad R., Brand M.I., Stone D., Keshavarzian A., and Qiao L. Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells. European Journal of Immunology 36 8 (2006) 2215-2222
    • (2006) European Journal of Immunology , vol.36 , Issue.8 , pp. 2215-2222
    • Fayad, R.1    Brand, M.I.2    Stone, D.3    Keshavarzian, A.4    Qiao, L.5
  • 109
    • 19044393886 scopus 로고    scopus 로고
    • Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia
    • Kim S., Fotiadu A., and Kotoula V. Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia. Clinical Immunology (Orlando, Fla) 115 3 (2005) 286-294
    • (2005) Clinical Immunology (Orlando, Fla) , vol.115 , Issue.3 , pp. 286-294
    • Kim, S.1    Fotiadu, A.2    Kotoula, V.3
  • 110
    • 1542283729 scopus 로고    scopus 로고
    • Modulation of macrophage differentiation and activation by decoy receptor 3
    • Chang Y.C., Hsu T.L., Lin H.H., et al. Modulation of macrophage differentiation and activation by decoy receptor 3. Journal of Leukocyte Biology 75 3 (2004) 486-494
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.3 , pp. 486-494
    • Chang, Y.C.1    Hsu, T.L.2    Lin, H.H.3
  • 111
    • 0141888351 scopus 로고    scopus 로고
    • Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue
    • Wortinger M.A., Foley J.W., Larocque P., et al. Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue. Immunology 110 2 (2003) 225-233
    • (2003) Immunology , vol.110 , Issue.2 , pp. 225-233
    • Wortinger, M.A.1    Foley, J.W.2    Larocque, P.3
  • 112
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt M.F., Kabesch M., Liang L., et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448 7152 (2007) 470-473
    • (2007) Nature , vol.448 , Issue.7152 , pp. 470-473
    • Moffatt, M.F.1    Kabesch, M.2    Liang, L.3
  • 113
    • 40049092784 scopus 로고    scopus 로고
    • Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population
    • Hirota T., Harada M., Sakashita M., et al. Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. The Journal of Allergy and Clinical Immunology 121 3 (2008) 769-770
    • (2008) The Journal of Allergy and Clinical Immunology , vol.121 , Issue.3 , pp. 769-770
    • Hirota, T.1    Harada, M.2    Sakashita, M.3
  • 115
    • 57149129440 scopus 로고    scopus 로고
    • ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry
    • Sleiman P.M., Annaiah K., Imielinski M., et al. ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. The Journal of Allergy and Clinical Immunology 122 6 (2008) 1225-1227
    • (2008) The Journal of Allergy and Clinical Immunology , vol.122 , Issue.6 , pp. 1225-1227
    • Sleiman, P.M.1    Annaiah, K.2    Imielinski, M.3
  • 116
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Burton P.R., Clayton D.G., Cardon L.R., et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39 11 (2007) 1329-1337
    • (2007) Nature Genetics , vol.39 , Issue.11 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3
  • 117
    • 38649108122 scopus 로고    scopus 로고
    • A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
    • Nath S.K., Han S., Kim-Howard X., et al. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nature Genetics 40 2 (2008) 152-154
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 152-154
    • Nath, S.K.1    Han, S.2    Kim-Howard, X.3
  • 118
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • Harley J.B., Alarcon-Riquelme M.E., Criswell L.A., et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nature Genetics 40 2 (2008) 204-210
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 204-210
    • Harley, J.B.1    Alarcon-Riquelme, M.E.2    Criswell, L.A.3
  • 119
    • 40049108936 scopus 로고    scopus 로고
    • Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    • Hom G., Graham R.R., Modrek B., et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. The New England Journal of Medicine 358 9 (2008) 900-909
    • (2008) The New England Journal of Medicine , vol.358 , Issue.9 , pp. 900-909
    • Hom, G.1    Graham, R.R.2    Modrek, B.3
  • 120
    • 38649138296 scopus 로고    scopus 로고
    • Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
    • Kozyrev S.V., Abelson A.K., Wojcik J., et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nature Genetics 40 2 (2008) 211-216
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 211-216
    • Kozyrev, S.V.1    Abelson, A.K.2    Wojcik, J.3
  • 121
    • 34548849168 scopus 로고    scopus 로고
    • TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study
    • Plenge R.M., Seielstad M., Padyukov L., et al. TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study. The New England Journal of Medicine 357 12 (2007) 1199-1209
    • (2007) The New England Journal of Medicine , vol.357 , Issue.12 , pp. 1199-1209
    • Plenge, R.M.1    Seielstad, M.2    Padyukov, L.3
  • 122
    • 47249158540 scopus 로고    scopus 로고
    • Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis
    • Behrens E.M., Finkel T.H., Bradfield J.P., et al. Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis. Arthritis and Rheumatism 58 7 (2008) 2206-2207
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.7 , pp. 2206-2207
    • Behrens, E.M.1    Finkel, T.H.2    Bradfield, J.P.3
  • 123
    • 36549003138 scopus 로고    scopus 로고
    • Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    • Plenge R.M., Cotsapas C., Davies L., et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nature Genetics 39 12 (2007) 1477-1482
    • (2007) Nature Genetics , vol.39 , Issue.12 , pp. 1477-1482
    • Plenge, R.M.1    Cotsapas, C.2    Davies, L.3
  • 124
    • 52949131340 scopus 로고    scopus 로고
    • Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    • Barton A., Thomson W., Ke X., et al. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40 10 (2008) 1156-1159
    • (2008) Nature Genetics , vol.40 , Issue.10 , pp. 1156-1159
    • Barton, A.1    Thomson, W.2    Ke, X.3
  • 125
    • 52949111858 scopus 로고    scopus 로고
    • Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    • Raychaudhuri S., Remmers E.F., Lee A.T., et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nature Genetics 40 10 (2008) 1216-1223
    • (2008) Nature Genetics , vol.40 , Issue.10 , pp. 1216-1223
    • Raychaudhuri, S.1    Remmers, E.F.2    Lee, A.T.3
  • 126
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • Hafler D.A., Compston A., Sawcer S., et al. Risk alleles for multiple sclerosis identified by a genomewide study. The New England Journal of Medicine 357 9 (2007) 851-862
    • (2007) The New England Journal of Medicine , vol.357 , Issue.9 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3
  • 127
    • 56749098072 scopus 로고    scopus 로고
    • Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
    • Aulchenko Y.S., Hoppenbrouwers I.A., Ramagopalan S.V., et al. Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nature Genetics 40 12 (2008) 1402-1403
    • (2008) Nature Genetics , vol.40 , Issue.12 , pp. 1402-1403
    • Aulchenko, Y.S.1    Hoppenbrouwers, I.A.2    Ramagopalan, S.V.3
  • 128
    • 33745169029 scopus 로고    scopus 로고
    • Role of PTPN22 in type 1 diabetes and other autoimmune diseases
    • Bottini N., Vang T., Cucca F., and Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Seminars in Immunology 18 4 (2006) 207-213
    • (2006) Seminars in Immunology , vol.18 , Issue.4 , pp. 207-213
    • Bottini, N.1    Vang, T.2    Cucca, F.3    Mustelin, T.4
  • 129
    • 36849012027 scopus 로고    scopus 로고
    • Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    • Nejentsev S., Howson J.M., Walker N.M., et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450 7171 (2007) 887-892
    • (2007) Nature , vol.450 , Issue.7171 , pp. 887-892
    • Nejentsev, S.1    Howson, J.M.2    Walker, N.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.