Aromatic esters of progesterone as 5α-reductase and prostate growth inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 3, 2009, Pages 655-662

  Bratoeff, Eugene ^a   Segura, Tania ^a   Recillas, Sergio ^b   Carrizales, Eric ^b   Palacios, Anay ^b   Heuze, Ivonne ^b   Cabeza, Marisa ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

Author keywords

5a reductase; 5a reductase inhibitors; Androgen receptor; Aromatic progesterone esters; Human prostate; Inhibition

Indexed keywords

17ALPHA BENZOYLOXY 4ALPHA,5ALPHA EPOXYPREGN 4 ENE 3,2 DIONE; 17ALPHA BENZOYLOXYPREGN 4 ENE 3,20 DIONE; 17ALPHA P BROMOBENZOYLOXY 4ALPHA,5ALPHA EPOXYPREGN 4 ENE 3,20 DIONE; 17ALPHA P BROMOBENZOYLOXYPREGN 4 ENE 3,20 DIONE; ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATIC COMPOUND; BROMINE; EPOXIDE; ESTER DERIVATIVE; FINASTERIDE; HYDROXYPROGESTERONE ACETATE; MIBOLERONE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; ESTER; GROWTH INHIBITOR; PROGESTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOM; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOSOL; DRUG BINDING; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GONADECTOMY; HAMSTER; HOMOGENATE; HORMONE DEPENDENCE; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROSTATE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; IC50; METABOLISM; PATHOLOGY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WISTAR RAT;

CRICETINAE; RATTUS;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 5-ALPHA REDUCTASE INHIBITORS; ANIMALS; BROMINE; CRICETINAE; DIHYDROTESTOSTERONE; ENZYME INHIBITORS; ESTERS; GROWTH INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; PROGESTERONE; PROSTATE; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE;

EID: 70749120407     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802323720     Document Type: Article

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