Adherence to isoniazid prophylaxis among HIV-infected children: A randomized controlled trial comparing two dosing schedules

BMC Medicine

Volumn 7, Issue , 2009, Pages 67-

  le Roux, Stanzi M ^a   Cotton, Mark F ^b   Golub, Jonathan E ^c   le Roux, David M ^a   Workman, Lesley ^a   Zar, Heather J ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISONIAZID; PLACEBO;

ARTICLE; CHEMOPROPHYLAXIS; CHILD; CHILD HEALTH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT ATTITUDE; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SOUTH AFRICA; TUBERCULOSIS;

EID: 70749084652     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-7-67     Document Type: Article

References (45)

1. UNAIDS Report on the global AIDS epidemic. 2008, Geneva: UNAIDS.
2. Chintu C, Mudenda V, Lucas S, Nunn A, Lishimpi K, Maswahu D, Kasolo F, Mwaba P, Bhat G, Terunuma H, Zumla A, . UNZA-UCLMS Project Paediatric Post-mortem Study Group Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study. Lancet 2002, 360(9338):985-990. 12383668, 10.1016/S0140-6736(02)11082-8.
3. Hesseling AC, Westra AE, Werschkull H, Donald PR, Beyers N, Hussey GD, El-Sadr W, Schaaf HS. Outcome of HIV infected children with culture confirmed tuberculosis. Arch Dis Child 2005, 90(11):1171-1174. 15964862, 10.1136/adc.2004.070466, 1720190.
4. Woldehanna S, Volmink J. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev 2004, (1):CD000171.
5. Grimwade K, Swingler. Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV. Cochrane Database Syst Rev 2003, (3):CD003108.
6. Grimwade K, Swingler GH. Cotrimoxazole prophylaxis for opportunistic infections in children with HIV infection. Cochrane Database Syst Rev 2006, (1):CD003508.
7. Sutcliffe CG, van Dijk JH, Bolton C, Persaud D, Moss WJ. Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa. Lancet Infect Dis 2008, 8(8):477-489. 18652994, 10.1016/S1473-3099(08)70180-4.
8. Zar HJ, Cotton MF, Strauss S, Karpakis J, Hussey G, Schaaf HS, Rabie H, Lombard CJ. Effect of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial. BMJ 2007, 334(7585):136. 17085459, 10.1136/bmj.39000.486400.55, 1779846.
9. Szakacs TA, Wilson D, Cameron DW, Clark M, Kocheleff P, Muller FJ, McCarthy AE. Adherence with isoniazid for prevention of tuberculosis among HIV-infected adults in South Africa. BMC Infect Dis 2006, 6:97. 16772037, 10.1186/1471-2334-6-97, 1513236.
10. Zachariah R, Harries AD, Luo C, Bachman G, Graham SM. Scaling-up co-trimoxazole prophylaxis in HIV-exposed and HIV-infected children in high HIV-prevalence countries. Lancet Infect Dis 2007, 7(10):686-693. 17897611, 10.1016/S1473-3099(07)70239-6.
11. Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM. A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries. Pediatr Infect Dis J 2008, 27(8):686-691. 18574439, 10.1097/INF.0b013e31816dd325.
12. Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA 2006, 296(6):679-690. 16896111, 10.1001/jama.296.6.679.
13. Mwinga A, Hosp M, Godfrey-Faussett P, Quigley M, Mwaba P, Mugala BN, Nyirenda O, Luo N, Pobee J, Elliott AM, McAdam KP, Porter JD. Twice weekly tuberculosis preventive therapy in HIV infection in Zambia. Aids 1998, 12(18):2447-2457. 9875583, 10.1097/00002030-199818000-00014.
14. World Health Organization Treatment of tuberculosis: guidelines for national programmes. 2003, Geneva: WHO, Third.
15. Te Water Naude JM, Donald PR, Hussey GD, Kibel MA, Louw A, Perkins DR, Schaaf HS. Twice weekly vs. daily chemotherapy for childhood tuberculosis. Pediatr Infect Dis J 2000, 19(5):405-410. 10819335, 10.1097/00006454-200005000-00004.
16. Ferebee SH. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibl Tuberc 1970, 26:28-106.
17. Steele RG, Anderson B, Rindel B, Dreyer ML, Perrin K, Christensen R, Tyc V, Flynn PM. Adherence to antiretroviral therapy among HIV-positive children: examination of the role of caregiver health beliefs. AIDS Care 2001, 13(5):617-629. 11571008, 10.1080/09540120120063241.
18. Nabukeera-Barungi N, Kalyesubula I, Kekitiinwa A, Byakika-Tusiime J, Musoke P. Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala. Ann Trop Paediatr 2007, 27(2):123-131. 17565809, 10.1179/146532807X192499.
19. Berg KM, Arnsten JH. Practical and conceptual challenges in measuring antiretroviral adherence. J Acquir Immune Defic Syndr 2006, 43(Suppl 1):S79-87.
20. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, Wagener MM, Singh N. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 2000, 133(1):21-30.
21. Diggle P, Heagerty P, Liang K, Zeger S. Analysis of longitudinal data. 2002, New York: Oxford University Press, Second.
22. Stata Statistical Software Release 10.0. 2007, Texas: Stata Corporation, 10.
23. World Health Organization The global plan to stop TB 2006-2015: actions for life towards a world free of tuberculosis. 2006, Geneva: WHO.
24. World Health Organization Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2006, Geneva: WHO.
25. Marais BJ, Graham SM, Cotton MF, Beyers N. Diagnostic and management challenges for childhood tuberculosis in the era of HIV. J Infect Dis 2007, 196(Suppl 1):S76-85. 17624829, 10.1086/518659.
26. Orrell C, Bangsberg DR, Badri M, Wood R. Adherence is not a barrier to successful antiretroviral therapy in South Africa. Aids 2003, 17(9):1369-1375. 12799558, 10.1097/00002030-200306130-00011.
27. Reddi A, Leeper SC, Grobler AC, Geddes R, France KH, Dorse GL, Vlok WJ, Mntambo M, Thomas M, Nixon K. Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa. BMC Pediatr 2007, 7:13. 17367540, 10.1186/1471-2431-7-13, 1847430.
28. Davies MA, Boulle A, Fakir T, Nuttall J, Eley B. Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study. BMC Pediatr 2008, 8(1):34. 18771599, 10.1186/1471-2431-8-34, 2533648.
29. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005, 353(5):487-497. 16079372, 10.1056/NEJMra050100.
30. Rowe KA, Makhubele B, Hargreaves JR, Porter JD, Hausler HP, Pronyk PM. Adherence to TB preventive therapy for HIV-positive patients in rural South Africa: implications for antiretroviral delivery in resource-poor settings?. Int J Tuberc Lung Dis 2005, 9(3):263-269.
31. Lugada ES, Watera C, Nakiyingi J, Elliott A, Brink A, Nanyunja M, French N, Antivelink L, Gilks C, Whitworth J. Operational assessment of isoniazid prophylaxis in a community AIDS service organisation in Uganda. Int J Tuberc Lung Dis 2002, 6(4):326-331.
32. Comstock GW. Isoniazid prophylaxis in an undeveloped area. Am Rev Respir Dis 1962, 86:810-822.
33. Marais BJ, van Zyl S, Schaaf HS, van Aardt M, Gie RP, Beyers N. Adherence to isoniazid preventive chemotherapy: a prospective community based study. Arch Dis Child 2006, 91(9):762-765. 16737993, 10.1136/adc.2006.097220, 2082929.
34. van Zyl S, Marais BJ, Hesseling AC, Gie RP, Beyers N, Schaaf HS. Adherence to anti-tuberculosis chemoprophylaxis and treatment in children. Int J Tuberc Lung Dis 2006, 10(1):13-18.
35. Starr M, Sawyer S, Carlin J, Powell C, Newman R, Johnson P. A novel approach to monitoring adherence to preventive therapy for tuberculosis in adolescence. J Paediatr Child Health 1999, 35(4):350-354. 10457290, 10.1046/j.1440-1754.1999.00371.x.
36. Mohammed A, Myer L, Ehrlich R, Wood R, Cilliers F, Maartens G. Randomised controlled trial of isoniazid preventive therapy in South African adults with advanced HIV disease. Int J Tuberc Lung Dis 2007, 11(10):1114-1120.
37. Davies MA, Boulle A, Fakir T, Nuttall J, Eley B. Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study. BMC Pediatr 2008, 8:34. 18771599, 10.1186/1471-2431-8-34, 2533648.
38. Blumberg EJ, Hovell MF, Kelley NJ, Vera AY, Sipan CL, Berg JP. Self-report INH adherence measures were reliable and valid in Latino adolescents with latent tuberculosis infection. J Clin Epidemiol 2005, 58(6):645-648. 15878479, 10.1016/j.jclinepi.2004.11.022.
39. Munro SA, Lewin SA, Smith HJ, Engel ME, Fretheim A, Volmink J. Patient adherence to tuberculosis treatment: a systematic review of qualitative research. PLoS Med 2007, 4(7):e238. 17676945, 10.1371/journal.pmed.0040238, 1925126.
40. Simoni JM, Montgomery A, Martin E, New M, Demas PA, Rana S. Adherence to antiretroviral therapy for pediatric HIV infection: a qualitative systematic review with recommendations for research and clinical management. Pediatrics 2007, 119(6):e1371-1383. 17533177, 10.1542/peds.2006-1232.
41. Gibb DM, Goodall RL, Giacomet V, McGee L, Compagnucci A, Lyall H. Adherence to prescribed antiretroviral therapy in human immunodeficiency virus-infected children in the PENTA 5 trial. Pediatr Infect Dis J 2003, 22(1):56-62. 12544410, 10.1097/00006454-200301000-00015.
42. Mellins CA, Brackis-Cott E, Dolezal C, Abrams EJ. The role of psychosocial and family factors in adherence to antiretroviral treatment in human immunodeficiency virus-infected children. Pediatr Infect Dis J 2004, 23(11):1035-1041. 15545859, 10.1097/01.inf.0000143646.15240.ac.
43. Elise A, France AM, Louise WM, Bata D, Francois R, Roger S, Philippe M. Assessment of adherence to highly active antiretroviral therapy in a cohort of African HIV-infected children in Abidjan, Cote d'Ivoire. J Acquir Immune Defic Syndr 2005, 40(4):498-500. 16280708, 10.1097/01.qai.0000168180.76405.5f.
44. Steele RG, Grauer D. Adherence to antiretroviral therapy for pediatric HIV infection: review of the literature and recommendations for research. Clin Child Fam Psychol Rev 2003, 6(1):17-30. 12659449, 10.1023/A:1022261905640.
45. Polisset J, Ametonou F, Arrive E, Aho A, Perez F. Correlates of adherence to antiretroviral therapy in HIV-infected children in Lome, Togo, West Africa. AIDS Behav 2008, 13(1):23-32. 18654845, 10.1007/s10461-008-9437-6.