Activation of calcitonin gene-related peptide receptor during ozone inhalation contributes to airway epithelial injury and repair

Toxicologic Pathology

Volumn 37, Issue 6, 2009, Pages 805-813

  Oslund, Karen L ^a   Hyde, Dallas M ^b   Putney, Leialoha F ^b   Alfaro, Mario F ^b   Walby, William F ^b   Tyler, Nancy K ^b   Schelegle, Edward S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Calcitonin gene related peptide receptor; Cell proliferation; Neuropeptide; Neutrophil emigration; Oxidant airway injury

Indexed keywords

BROMODEOXYCYTIDINE; CALCITONIN GENE RELATED PEPTIDE[8-37]; ETHIDIUM; HYDROGEN PEROXIDE; OZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CELL PROLIFERATION; CONTROL GROUP; CONTROLLED STUDY; DISSECTION; DRUG ACTIVATION; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; INHALATION; LUNG INJURY; LUNG LAVAGE; LUNG LOBE; MALE; NECROSIS; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RESPIRATORY EPITHELIUM; WISTAR RAT;

ANIMALS; APOPTOSIS; BRONCHIOLES; BRONCHOALVEOLAR LAVAGE FLUID; CALCITONIN GENE-RELATED PEPTIDE; CELL LINE, TRANSFORMED; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; INHALATION EXPOSURE; MALE; NECROSIS; NEUTROPHILS; OXIDATIVE STRESS; OZONE; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RESPIRATORY MUCOSA; RESPIRATORY RATE; TIDAL VOLUME;

RATTUS; RATTUS NORVEGICUS;

EID: 70649111143     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309345691     Document Type: Article

References (43)

1. Ahluwalia, A., and Perretti, M. (1994). Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. Eur J Pharmacol 264, 407-15.
2. 18O-labeled ozone reaction product in the respiratory tract of the rat. Inhal Toxicol 16, 1-9.
3. Amann, R., Schuligoi, R., Lanz, I., and Donnerer, J. (1995). Histamine-induced edema in the rat paw-effect of capsaicin denervation and a CGRP receptor antagonist. Eur J Pharmacol 279 (2-3), 227-31.
4. Ay, I., and Tuncer, M. (2004). Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney. Pharmacology 71 (4), 209-15.
5. Bulut, K., Felderbauer, P., Deters, S., Hoeck, K., Schmidt-Choudhury, A., Schmidt, W. E., and Hoffmann, P. (2008). Sensory neuropeptides and epithelial cell restitution: The relevance of SP-and CGRP-stimulated mast cells. Int J Colorectal Dis 23 (5), 535-41.
6. Castleman, W. L., Tyler, W. S., and Dungworth, D. L. (1977). Lesions in respiratory bronchioles and conduction airways of monkeys exposed to ambient levels of ozone. Exp Mol Pathol 26, 384-400.
7. Castro-Obregon, S., Rao, R. V., del Rio, G., Chen, S. F., Poksay, K. S., Rabizadeh, S., Vesce, S., Zhang, X. K., Swanson, R. A., and Bredesen, D. E. (2004). Alternative, nonapoptotic programmed cell death: Mediation by arrestin 2, ERK2, and Nur77. J Biol Chem 279, 17543-53.
8. Dolinay, T., Kaminaski, N., Felgendreher, M., Kim, H. P., Reynolds, P., Watkins, S. C., Karp, D., Uhlig, S., and Choi, A. M. K. (2006). Expression profiling of target genes in ventilator-induced lung injury. Physiol Genomics 26, 68-75.
9. 3. Lab Invest 35, 246-57.
10. Fox, G. A., Paterson, N. A., and McCormack, D. G. (1996). Calcitonin generelated peptide does not mediate the abnormal vascular reactivity observed in a rat model of acute Pseudomonas pneumonia. J Cardiovasc Pharmacol 27 (6), 901-7.
11. Gherardini, G., Gurlek, A., Milner, S. M., Matarasso, A., Evans, G. R. D., Jernbeck, J., and Lundeberg, T. (1998). Calcitonin gene-related peptide improves skin flap survival and tissue inflammation. Neuropeptides 32 (3), 269-73.
12. Grant, A. D., Gerard, N. P., and Brain, S. D. (2002). Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear. Br J Pharmacol 135 (2), 356-62.
13. Groneberg, D. A., Quarcoo, D., Frossard, N., and Fischer, A. (2004). Neurogenic mechanisms in bronchial inflammatory diseases. Allergy 59, 1139-52.
14. Hyde, D. M., Miller, L. A., McDonald, R. J., Stovall, M. Y., Wong, V., Pinkerton, K. E., Wegner, C. D., Rothlein, R., and Plopper, C. G. (1999). Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys. Am J Physiology 277
15. (Lung Cell Mol Physiol 21), L1190-98.
16. Jansen, G. B., Torkvist, L., Lofgren, O., Raud, J., and Lundeberg, T. (1999). Effects of calcitonin gene-related peptide on tissue survival, blood flow and neutrophil recruitment in experimental skin flaps. Br J Plast Surg 52, 299-303. (Pubitemid 29286925)
17. Kim, J. S., Rabe, K. F., Magnussen, H., Green, J. M., and White, S. R. (1995) Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins. Am J Physiol 269
18. (Lung Cell Mol Physiol 13), L119-26.
19. Koren, H. S., Devlin, R. B., Graham, D. E., Mann, R., McGee, M. P., Horstman, D. H., Kozumbo W. J., Becker, S., House, D. E., and McDonnell, W. F. (1989). Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis 139, 407-15.
20. Maggi, C. A., Giachetti, A., Dey, R. D., and Said, S. I. (1995). Neuropeptides as regulators of airway function: Vasoactive intestinal peptide and the tachykinins. Physiol Rev 75 (2), 277-322.
21. Mark, J. C., and Barnes, P. J. (1988). Autoradiographic localization of calcitonin gene-related peptide (CGRP) binding sites in human and guinea pig lung. Peptides 9, 957-63.
22. Mikulec, A. A., and Tanelian, D. L. (1996). CGRP increases the rate of corneal re-epithelialization in an in vitro whole mount preparation. Journal of Ocular Pharmacol Ther 12 (4), 417-23.
23. Oslund, K. L., Hyde, D. M., Putney, L. F., Alfaro, M. F., Walby, W. F., Tyler, N. K., and Schelegle, E. S. (2008). Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. Am J Respir Cell Mol Biol 39, 279-88.
24. Pino, M. V., Levin, J. R., Stovall, M. Y., and Hyde, D. M. (1992). Pulmonary inflammation and epithelial injury in response to acute ozone exposure in the rat. Toxicol Appl Pharmacol 112 (1), 64-72.
25. Pino, M. V., Stovall, M. Y., Levin, J. R., Devlin, R. B., Koren, H. S., and Hyde, D. M. (1992). Acute ozone-induced lung injury in neutrophil-depleted rats. Toxicol Appl Pharmacol 114, 268-76.
26. Plopper, C. G., Dungworth, D. L., and Tyler, W. S. (1973). Pulmonary lesions in rats exposed to ozone: A correlated light and electron microscopic study. Am J Pathol 71, 375-94.
27. Puchelle, E., Le Simple, P., Hajj, R., and Coraux, C. (2006). Regeneration of injured airway epithelium. Ann Pharm Fr 64, 107-13. [in French].
28. Ren, Y. H., Qin, X. Q., Guan, C. X., Luo, Z. Q., Zhang, C. Q., and Sun, X. H. (2004). Temporal and spatial distribution of VIP, CGRP and their receptors in the development of airway hyperresponsiveness in the lungs. Acta Physiologica Sinica 56 (2), 137-46.
29. Richter, J., Andersson, R., Edvinsson, L., and Gullberg, U. (1992). Calcitonin gene-related peptide (CGRP) activates human neutrophils-inhibition by chemotactic peptide antagonist BOC-MLP. Immunology 77, 416-21.
30. Sanghavi, J. N., Rabe, K. F., Kim, J. S., Magnussen, H., Leff, A. R., and White, S. R. (1994). Migration of human and guinea pig airway epithelial cells in response to calcitonin gene-related peptide. Am J Respir Cell Mol Biol 11 (2), 181-87.
31. Schelegle, E. S., Alfaro, M. F., Putney, L., Stovall, M., Tyler, N., and Hyde, D. M. (2001). Effect of C-fiber-mediated, ozone-induced rapid shallow breathing on airway epithelial injury in rats. J Appl Physiol 91 (4), 1611-18.
32. Schelegle, E. S., Walby, W. F., Alfaro, M. F., Wong, V. J., Putney, L., Stovall, M. Y., Sterner-Kock, A., Hyde, D. M., and Plopper, C. G. (2003). Repeated episodes of ozone inhalation attenuates airway injury/repair and release of substance P, but not adaptation. Toxicol Appl Pharmacol 186 (3), 127-42.
33. Shimosegawa, T., and Said, S. I. (1991). Pulmonary calcitonin gene-related peptide immunoreactivity: Nerve-endocrine cell interrelationships. Am J Respir Cell Mol Biol 4 (2), 126-34.
34. Shin, H. J., Lee, B. H., Yeo, M. G., Oh, S. H., Park, J. D., Park, K. K., Chung, J. H., Moon, C. K., and Lee, M. O. (2004). Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung. Carcinogenesis 25 (8), 1467-75.
35. Solway, J., and Leff, A. R. (1991). Sensory neuropeptides and airway function. J Appl Physiol 71 (6), 2077-87.
36. Sterner-Kock, A., Vesely, K. R., Stovall, M. Y., Schelegle, E. S., Green, J. F., and Hyde, D. M. (1996). Neonatal capsaicin treatment increases the severity of ozone-induced lung injury. Am J Respir Crit Care Med 153, 436-43.
37. Thompson, C. A., and Burcham, C. (2008). Genome-wide transcriptional responses to acrolein. Chem Res Toxicol 21, 2245-56.
38. Vesely, K. R., Hyde, D. M., Stovall, M. Y., Harkema, J. R., Green, J. F., and Schelegle, E. S. (1999). Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. J Appl Physiol 86 (3), 951-62.
39. Vesely, K. R., Schelegle, E. S., Stovall, M. Y., Harkema, J. R., Green, J. F., and Hyde, D. M. (1999). Breathing pattern response and epithelial labeling in ozone-induced airway injury in neutrophil-depleted rats. Am J Respir Cell Mol Biol 20 (4), 699-709.
40. White, S. R., Hershenson, M. B., Sigrist, K. S., Zimmermann, A., and Solway, J. (1993). Proliferation of guinea pig tracheal epithelial cells induced by calcitonin gene-related peptide. Am J Respir Cell Mol Biol 8, 592-96.
41. Wu, H., Guan, C., Qin, X., Xiang, Y., Qi, M., Luo, Z., and Zhang, C. (2007). Up-regulation of substance P receptor expression by calcitonin generelated peptide, a possible cooperative action of two neuropeptides involved in airway inflammation. Pulm Pharmacol Ther 20 (5), 513-24.
42. Zimmerman, B. J., Anderson, D. C., and Granger, N. (1992). Neuropeptides promote neutrophil adherence to endothelial cell monolayers. Am J Physiol 263
43. (Gastrointest Liver Physiol 26), G678-82.