Effects of the nitric oxide synthase inhibitor L-NAME on different memory components as assessed in the object recognition task in the rat

Behavioural Brain Research

Volumn 207, Issue 1, 2010, Pages 208-214

  Boultadakis, Antonios ^a   Georgiadou, Georgia ^a   Pitsikas, Nikolaos ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

L NAME; Nitric oxide; Object recognition; Rat; Recognition memory

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISCRIMINATION LEARNING; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; EXPLORATORY BEHAVIOR; INFORMATION RETRIEVAL; INFORMATION STORAGE; LOW DRUG DOSE; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MOTOR ACTIVITY; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; WORKING MEMORY;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXPLORATORY BEHAVIOR; MALE; MOTOR ACTIVITY; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY); SPATIAL BEHAVIOR; TIME FACTORS;

EID: 70649106815     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.10.007     Document Type: Article

References (56)

1. Bannerman D.M., Chapman P.F., Kelly P.A.T., Butcher S.P., and Morris R.G.M. Inhibition of nitric oxide synthase does not impair spatial learning. J Neurosci 14 (1994) 7404-7414
2. Baratti C.M., and Kopf S.R. A nitric oxide synthase inhibitor impairs memory storage in mice. Neurobiol Learn Mem 65 (1996) 197-201
3. Bartolini L., Casamenti F., and Pepeu G. Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions. Pharmacol Biochem Behav 53 (1996) 277-283
4. Cavoy A., and Delacour J. Spatial but not object recognition is impaired by aging in rats. Physiol Behav 53 (1993) 527-530
5. Chapman P.F., Atkins C.M., Allen M.T., Haley J.E., and Steinmetz J.E. Inhibition of nitric oxide synthesis impairs two different forms of learning. Neuroreport 3 (1992) 567-570
6. Cobb B.L., Ryan K.L., Frei R.M., Guel-Gomez V., and Mickley G.A. Chronic administration of L-NAME in drinking water alters working memory in rats. Brain Res Bull 38 (1995) 203-207
7. Contestabile A., Monti B., Contestabile A., and Ciani E. Brain nitric oxide and its dual role in neuroprotection/neurodegeneration: understanding molecular mechanisms to devise drug approaches. Curr Med Chem 10 (2003) 1241-1253
8. Dere E., Huston J.P., and De Souza Silva M.A. The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci Biobehav Rev 31 (2007) 673-704
9. Doyle C., Holscher C., Rowan M.J., and Anwyl R. The selective neuronal NO synthase inhibitor 7-nitroindazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo. J Neurosci 16 (1996) 418-424
10. Du W., and Harvey J.A. The nitric oxide synthesis inhibitor L-NAME facilitates associative learning. Prog Neuro-Psychopharmacol Biol Psychiatry 20 (1996) 1183-1195
11. Du W., Weiss H., and Harvey J.A. Associative learning is enhanced by selective neuronal nitric oxide synthase inhibitors and retarded by a nitric oxide donor in the rabbit. Psychopharmacology 150 (2000) 264-271
12. Edwards T.M., and Rickard N.S. New perspectives on the mechanisms through which nitric oxide may affect learning and memory processes. Neurosci Biobehav Rev 31 (2007) 413-425
13. Ennaceur A., and Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1. Behavioral data. Behav Brain Res 31 (1988) 47-59
14. Estall L.B., Grant S.J., and Cicala G. Inhibition of nitric oxide (NO) production selectively impairs learning and memory in the rat. Pharmacol Biochem Behav 46 (1993) 959-962
15. Fejgin K., Palsson E., Wass C., Svensson L., and Klamer D. Nitric oxide signaling in the medial prefrontal cortex is involved in the biochemical and behavioral effects of phencyclidine. Neuropsychopharmacology 33 (2007) 1874-1883
16. Forestiero D., Manfrim C.M., Guimares F.S., and deOliveira R.M. Anxiolytic-like effects induced by nitric oxide synthase inhibitors microinjected into the medial amygdala of rats. Psychopharmacology 184 (2006) 166-172
17. Garthwaite J. Glutamate nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 14 (1991) 60-67
18. Haley J.E., Wilcox G.L., and Chapman P.F. The role of nitric oxide in hippocampal long-term potentiation. Neuron 8 (1992) 211-216
19. Harooni H.E., Naghdi N., Sepehri H., and Rohani A.H. The role of hippocampal nitric oxide (NO) on learning and immediate, short- and long-term memory retrieval in inhibitory avoidance task in male adult rats. Behav Brain Res 201 (2009) 166-172
20. Hunter B., Zornetzer S.F., Jarvik M.E., and McGaugh J.L. Modulation of learning and memory: effects of drugs influencing neurotransmitters. In: Iversen L.L., Iversen S.D., and Snyder S.H. (Eds). Handbook of psychopharmacology vol. 19 (1988), Plenum, New York 531-577
21. Johnson D.M., Baker J.D., and Azorlosa J.L. Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide. Brain Res 857 (2000) 66-70
22. Kendrick K.M., Guevara-Guzman R., Zorilla J., Hinton M.R., Broad K.D., Mimmack M., et al. Formation of olfactory memories mediated by nitric oxide. Nature 388 (1997) 670-674
23. Khavandgar S., Homayoum H., and Zarrindast M.R. The effect of L-NAME and l-arginine on impairment of memory formation and state-dependent learning induced by morphine in mice. Psychopharmacology 167 (2003) 291-296
24. G-nitro-l-arginine methyl ester on spatial and cued learning. Neuroscience 83 (1998) 837-841
25. Knowles R.G., and Moncada S. Nitric oxide synthases in mammals. Biochem J 298 (1994) 249-258
26. Lei S.Z., Pan Z.H., Aggarwal S.K., Chen H.S.V., Hartnan J., Sucher N.J., et al. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 8 (1992) 1087-1099
27. Lipton S.A., Choi Y.B., Pan Z.H., Lei S.Z., Chen H.S.V., Sucher N.J., et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364 (1993) 626-632
28. Maalouf M., Dykes R.W., and Miasnikov A.A. Effects of D-AP5 and NMDA microiontophoresis on associative learning in the barrel cortex of awake rats. Brain Res 793 (1998) 149-168
29. Manzoni O., Prezeau L., Marin P., Deshager S., Bockaert J., and Fagni L. Nitric oxide-induced blockade of NMDA receptors. Neuron 8 (1992) 653-662
30. Manzoni O., and Bockaert J. Nitric oxide synthase activity endogenously modulates NMDA receptors. J Neurochem 61 (1993) 366-370
31. Moncada S., Palmer R.M.J., and Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43 (1991) 109-123
32. O'Dell T.J., Hawkins R.D., Kandel E.R., and Arancio O. Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. Proc Natl Acad Sci USA 88 (1991) 11285-11289
33. Paige J.S., and Jaffrey S.R. Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions. Curr Top Med Chem 7 (2007) 97-114
34. Pitsikas N., Rigamonti A.E., Cella S.G., Locatelli V., Sala M.E., and Muller E.E. Effects of molsidomine on scopolamine-induced amnesia and hypermotility in the rat. Eur J Pharmacol 426 (2001) 193-200
35. Pitsikas N., Rigamonti A.E., Cella S.G., and Muller E.E. Effects of the nitric oxide (NO) donor molsidomine on different memory components as assessed in the object recognition task in the rat. Psychopharmacology 162 (2002) 239-245
36. ω-nitro-l-argininemethylester-induced deficits in a memory task in the rat. Eur J Pharmacol 452 (2002) 83-86
37. Pitsikas N., Rigamonti A.E., Bonomo S.M., Cella S.G., and Muller E.E. Molsidomine antagonizes L-NAME-induced acquisition deficits in a recognition memory task in the rat. Pharmacol Res 47 (2003) 311-315
38. Pitsikas N. Effects of scopolamine and L-NAME on rats' performance in the object location test. Behav Brain Res 179 (2007) 294-298
39. Prast H., and Philippu A. Nitric oxide as modulator of neuronal function. Progr Neurobiol 64 (2001) 51-68
40. Prendergast M.A., Buccafusco J.J., and Terry Jr. A.V. Nitric oxide synthase inhibition impairs spatial navigation learning and induces conditioned taste aversion. Pharmacol Biochem Behav 57 (1997) 347-352
41. Rees D.D., Palmer R.M.J., Schulz R., Hodson H.F., and Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 (1990) 746-752
42. Schuman E.M., and Madison D.V. Locally distributed synaptic potentiation in the hippocampus. Science 263 (1994) 532-536
43. Smolenski A., Burckhardt A.M., Eigenthaler M., Butt E., Gambaryan S., Lohmann S., et al. Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO:cGMP effects. Naunyn-Schmiedeberg's Arch Pharmacol 358 (1998) 134-139
44. Stamler J.S., Singel D.J., and Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 258 (1992) 1898-1902
45. Steckler T., Drinkenburg W.H.I.M., Sahgal A., and Aggleton J.P. Recognition memory in rats. I. Concepts and classification. Progr Neurobiol 54 (1998) 289-311
46. Tobin J.R., Gorman L.K., Baxter M.G., and Traystman R.J. Nitric oxide synthase inhibition does not impair visual or spatial discrimination learning. Brain Res 694 (1995) 177-182
47. Vale A.L., Green S., Montgomery A.M., and Shafi S. The nitric oxide synthesis inhibitor L-NAME produces anxiogenic-like effects in the rat elevated plus maze test, but not in the social interaction test. J Psychopharmacol 12 (1998) 268-272
48. Vincent S.R., and Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46 (1992) 7755-7784
49. Wang X., and Robinson P.J. Cyclic GMP-dependent protein kinase and cellular signalling in the nervous system. J Neurochem 68 (1997) 443-456
50. Wass C., Archer T., Palsson E., Fejgin K., Klamer D., Engel J.A., et al. Effects of phencyclidine on spatial learning and memory: nitric oxide dependent-mechanisms. Behav Brain Res 171 (2006) 147-153
51. Wass C., Archer T., Palsson E., Fejgin K., Alexandersson A., Klamer D., et al. Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference memory. Behav Brain Res 174 (2006) 49-55
52. Wass C., Svensson L., Fejgin K., Palsson E., Archer T., Engel J.A., et al. Nitric oxide synthase inhibition attenuates phencyclidine-induced disruption of cognitive flexibility. Pharmacol Biochem Behav 89 (2008) 352-359
53. Watts J., Whitton P.S., and Pearce B. Unexpected effects of nitric oxide synthase inhibitors on extracellular nitrite levels in the hippocampus in vivo. Pharmacology 74 (2005) 163-168
54. Wiley J.L., and Willmore C.B. Effects of nitric oxide synthase inhibitors on timing and short-term memory in rats. Behav Pharmacol 11 (2000) 421-429
55. Yamada K., Noda Y., Nakayama S., Komori Y., Sugihara H., Hasegawa T., et al. Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain. Br J Pharmacol 115 (1995) 852-858
56. Zou L.B., Yamada K., Tanaka T., Kameyama T., and Nabeshima T. Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats. Neuropharmacology 37 (1998) 323-330