Alpha-fluoromethylhistidine, a histamine synthesis inhibitor, inhibits orexin-induced wakefulness in rats

Behavioural Brain Research

Volumn 207, Issue 1, 2010, Pages 151-154

  Yasuko, Seki ^a   Atanda, Akanmu Moses ^a   Masato, Matsuura ^a   Kazuhiko, Yanai ^b   Kazuki, Honda ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

FMH; Histamine; NREM sleep; Orexin; Rats; REM sleep; Wake

Indexed keywords

ALPHA FLUOROMETHYLHISTIDINE; HISTAMINE; OREXIN B; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; AROUSAL; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; HISTAMINE METABOLISM; MALE; METABOLIC INHIBITION; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP STAGE; SLEEP WAKING CYCLE; SPRAGUE DAWLEY RAT; WAKEFULNESS;

ANALYSIS OF VARIANCE; ANIMALS; AROUSAL; BEHAVIOR, ANIMAL; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; HISTAMINE; HISTIDINE DECARBOXYLASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SLEEP; WAKEFULNESS;

EID: 70649106809     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.09.049     Document Type: Article

References (21)

1. Akanmu M.A., Honda K., and Inoue S. Hypnotic effects of total aqueous extracts of Vervain hastata (Verbenaceae) in rats. Psych Clin Neurosci 56 (2002) 309-310
2. Akanmu M.A., and Honda K. Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats. Brain Res 1048 (2005) 138-145
3. Akanmu M.A., Songkram C., Kagechika H., and Honda K. A novel melatonin derivative modulates sleep-wake cycle in rats. Neurosci Lett 364 (2004) 199-202
4. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
5. Chu M., Huang Z.L., Qu W.M., Eguchi N., Yao M.H., and Urade Y. Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Neurosci Res 49 (2004) 417-420
6. Fernández-Novoa L., Franco-MAside A., Alvarez X.A., and Cacabelos R. Effects of histamine and alpha-fluoro methylhistidine on brain tumor necrosis factor levels in rats. Inflamm Res 44 1 (1995) 55-57
7. Gerashchenko D., Kohls M.D., Greco M.A., Waleh N.S., Salin-Pascual R., Kilduff T.S., et al. Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behaviour in the rat. J Neurosci 21 (2001) 7273-7283
8. Honda K., Komoda Y., and Inoué S. Oxidized glutathione regulates physiological sleep in unrestrained rats. Brain Res 636 (1994) 253-258
9. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
10. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435 (2001) 6-25
11. Monti J.M., D'Angelo L., Jantos H., and Pazos S. Effects of fluoromethylhistidine on sleep and wakefulness in the rat. J Neural Transm 72 2 (1988) 141-145
12. Oishi R., Itoh Y., Nishibori M., Saeki K., and Ueki S. Enhancement by alpha-fluoro methylhistidine of the thiopental sleep-prolonging action of delta 9-tetrahydrocannabino. Psychopharmacology (Berl) 95 1 (1988) 77-81
13. Onodera K., Yamatodani A., and Watanabe T. Effects of alpha-fluoro methylhistidine on locomotor activity, brain histamine and catecholamine rats. Methods Find Exp Clin Pharmacol 14 2 (1992) 97-105
14. Peyron C., Tighe D.K., Van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18 (1998) 9996-10015
15. Ramesh V., Thakkhar M.M., Strecker R.E., Basheer R., and McCarley R.W. Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Behav Brain Res 152 (2004) 271-278
16. Sakai N., Sakurai E., Onodera K., Asada H., Miura Y., and Watanabe T. Long-term depletion of brain histamine induced by alpha-fluoro methylhistidine increases feeding-associated locomotor activity in mice with a modulation of brain amino acid levels. Behav Brain Res 72 1-2 (1995) 83-88
17. Sakai N., Yamazaki S., Onodera K., Yanai K., Maeyama K., and Watanabe T. Effects of (S)-alpha-fluoro methylhistidine and (R) alpha-methylhistamine on locomotion of W/Wv mice. Pharmacol Biochem Behav 46 1 (1993) 95-99
18. Sugimoto K., Maeyama K., Alam K., Sakurai E., Onoue H., Kasugai T., et al. Brain histaminergic system in mast cell-deficient (Ws/Ws) rats: histamine content, histidine decarboxylase activity, and effects of (S) alpha-fluoromethylhistidine. J Neurochem 65 (1995) 791-797
19. Sweet D.C., Levine A.S., Billington C.J., and Kotz C.M. Feeding response to central orexins. Brain Res 821 (1999) 535-538
20. Willie J.T., Chemelli R.M., Sinton C.M., and Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 2 (2001) 429-458
21. Yamanaka A., Tsujino N., Funahashi H., Honda K., Guan J.L., Wang Q.P., et al. Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun 290 (2002) 1237-1245