Diagnosis of secondary adrenal insufficiency: Unstimulated early morning cortisol in saliva and serum in comparison with the insulin tolerance test

Hormone and Metabolic Research

Volumn 41, Issue 11, 2009, Pages 834-839

  Deutschbein, T ^a   Unger, N ^a   Mann, K ^a   Petersenn, S ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Adrenal cortex; Adrenocortical insuffiency; Basal cortisol; Hypopituitarism; Hypothalamic pituitaryadrenal axis

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE;

ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ADULT; ARTICLE; ASTROCYTOMA; BLOOD SAMPLING; CONTROLLED STUDY; CRANIOPHARYNGIOMA; EPENDYMOMA; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROLACTINOMA; RATHKE CLEFT CYST; SALIVA; SELLA TURCICA TUMOR;

ADRENAL INSUFFICIENCY; ADULT; CASE-CONTROL STUDIES; DIAGNOSTIC TECHNIQUES, ENDOCRINE; FEMALE; HUMANS; HYDROCORTISONE; INSULIN; MALE; MIDDLE AGED; SALIVA;

EID: 70649100490     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0029-1225630     Document Type: Article

References (42)

1. Arlt W, Allolio B. Adrenal insufficiency. Lancet 2003; 361: 1881-1893
2. Dorin RI, Qualls CR, Crapo LM. Diagnosis of adrenal insufficiency. Ann Intern Med 2003; 139: 194-204
3. Shah A, Stanhope R, Matthew D. Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ 1992; 304: 173-174
4. Hagg E, Asplund K, Lithner F. Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency. Clin Endocrinol (Oxf) 1987; 26: 221-226 (Pubitemid 17015709)
5. Watts NB, Tindall GT. Rapid assessment of corticotropin reserve after pituitary surgery. JAMA 1988; 259: 708-711
6. Erturk E, Jaffe CA, Barkan AL. Evaluation of the integrity of the hypothalamic-pituitary-adrenal axis by insulin hypoglycemia test. J Clin Endocrinol Metab 1998; 83: 2350-2354 (Pubitemid 28503026)
7. Jones SL, Trainer PJ, Perry L, Wass JA, Besser GM, Grossman A. An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year. Clin Endocrinol (Oxf) 1994; 41: 123-128
8. Schmidt IL, Lahner H, Mann K, Petersenn S. Diagnosis of adrenal insufficiency: Evaluation of the corticotropin-releasing hormone test and Basal serum cortisol in comparison to the insulin tolerance test in patients with hypothalamic-pituitary-adrenal disease. J Clin Endocrinol Metab 2003; 88: 4193-4198 (Pubitemid 37153719)
9. Lewis JG. Steroid Analysis in Saliva: An overview. Clin Biochem Rev 2006; 27: 139-146
10. Meulenberg PM, Ross HA, Swinkels LM, Benraad TJ. The effect of oral contraceptives on plasma-free and salivary cortisol and cortisone. Clin Chim Acta 1987; 165: 379-385
11. Umeda T, Hiramatsu R, Iwaoka T, Shimada T, Miura F, Sato T. Use of saliva for monitoring unbound free cortisol levels in serum. Clin Chim Acta 1981; 110: 245-253 (Pubitemid 11102567)
12. Riad-Fahmy D, Read GF, Walker RF, Griffiths K. Steroids in saliva for assessing endocrine function. Endocr Rev 1982; 3: 367-395
13. Vining RF, McGinley RA, Symons RG. Hormones in saliva: mode of entry and consequent implications for clinical interpretation. Clin Chem 1983; 29: 1752-1756
14. Groschl M, Wagner R, Rauh M, Dorr HG. Stability of salivary steroids: the influences of storage, food and dental care. Steroids 2001 ; 66: 737-741 (Pubitemid 32755770)
15. Chen YM, Cintron NM, Whitson PA. Long-term storage of salivary cortisol samples at room temperature. Clin Chem 1992; 38: 304
16. Castro M, Elias PC, Quidute AR, Halah FP, Moreira AC. Out-patient screening for Cushing's syndrome: the sensitivity of the combination of circadian rhythm and overnight dexamethasone suppression salivary cortisol tests. J Clin Endocrinol Metab 1999; 84: 878-882 (Pubitemid 29138212)
17. Papanicolaou DA, Mullen N, Kyrou I, Nieman LK. Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 2002; 87: 4515-4521 (Pubitemid 35247034)
18. Putignano P, Toja P, Dubini A, Pecori Giraldi F, Corsello SM, Cavagnini F. Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's syndrome. J Clin Endocrinol Metab 2003; 88: 4153-4157
19. Raff H, Raff JL, Findling JW. Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab 1998; 83: 2681-2686 (Pubitemid 28493760)
20. Trilck M, Flitsch J, Ludecke DK, Jung R, Petersenn S. Salivary cortisol measurement - a reliable method for the diagnosis of Cushing's syndrome. Exp Clin Endocrinol Diabetes 2005; 113: 225-230 (Pubitemid 40695329)
21. Reynolds RM, Stewart PM, SecklJR, Padfleld PL. Assessing the HPA axis in patients with pituitary disease: a UK survey. Clin Endocrinol (Oxf) 2006; 64: 82-85
22. Tuchelt H, Dekker K, Bahr V, Oelkers W. Dose-response relationship between plasma ACTH and serum cortisol in the insulin-hypoglycaemia test in 25 healthy subjects and 109 patients with pituitary disease. Clin Endocrinol (Oxf) 2000; 53: 301-307
23. Grinspoon SK, Biller BM. Clinical review 62: Laboratory assessment of adrenal insufficiency. J Clin Endocrinol Metab 1994; 79: 923-931
24. Aardal-Eriksson E, Karlberg BE, Holm AC. Salivary cortisol - an alternative to serum cortisol determinations in dynamic function tests. Clin Chem Lab Med 1998; 36: 215-222
25. Contreras LN, Arregger AL, Persi GG, Gonzalez NS, Cardoso EM. A new less-invasive and more informative low-dose ACTH test: salivary steroids in response to intramuscular corticotrophin. Clin Endocrinol (Oxf) 2004; 61: 675-682
26. Marcus-Perlman Y, Tordjman K, Greenman Y, Limor R, Shenkerman G, Osher E, Stern N. Low-dose ACTH (1 microg) salivary test: a potential alternative to the classical blood test. Clin Endocrinol (Oxf) 2006; 64: 215-218
27. Cetinkaya S, Ozon A, Yordam N. Diagnostic value of salivary cortisol in children with abnormal adrenal cortex functions. Horm Res 2007; 67: 301-306 (Pubitemid 46701496)
28. Laudat MH, Cerdas S, Fournier C, Guiban D, Guilhaume B, Luton JP. Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function. J Clin Endocrinol Metab 1988; 66: 343-348
29. Aardal E, Holm AC. cortisol in saliva - reference ranges and relation to cortisol in serum. Eur J Clin Chem Clin Biochem 1995; 33: 927-932 (Pubitemid 26012948)
30. Clements AD, Parker CR, The relationship between salivary cortisol concentrations in frozen versus mailed samples. Psychoneuroendocrinology 1998; 23: 613-616
31. Endert E, Ouwehand A, Fliers E, Prummel MF, Wiersinga WM. Establishment of reference values for endocrine tests. Part IV: Adrenal insufficiency. Neth J Med 2005; 63: 435-443 (Pubitemid 43019743)
32. Patel RS, Shaw SR, Macintyre H, McGarry GW, Wallace AM. Production of gender-specific morning salivary cortisol reference intervals using internationally accepted procedures. Clin Chem Lab Med 2004; 42: 1424-1429
33. Raff H, Homar PJ, Burns EA. Comparison of two methods for measuring salivary cortisol. Clin Chem 2002; 48: 207-208 (Pubitemid 34038149)
34. Inder WJ, Hunt PJ. Glucocorticoid replacement in pituitary surgery: guidelines for perioperative assessment and management. J Clin Endocrinol Metab 2002; 87: 2745-2750
35. Courtney CH, McAllister AS, McCance DR, Bell PM, Hadden DR, Leslie H, Sheridan B, Atkinson AB. Comparison of one week 0900 h serum Cortisol, low and standard dose synacthen tests with a 4 to 6 week insulin hypoglycaemia test after pituitary surgery in assessing HPA axis. Clin Endocrinol (Oxf) 2000; 53: 431-436 (Pubitemid 30802460)
36. Hout WM, Arafah BM, Salazar R, Selman W. Evaluation of the hypothalamic-pituitary-adrenal axis immediately after pituitary adenomectomy: is perioperative steroid therapy necessary? J Clin Endocrinol Metab 1988; 66: 1208-1212
37. Auchus RJ, Shewbridge RK, Shepherd MD. Which patients benefit from provocative adrenal testing after transsphenoidal pituitary surgery? Clin Endocrinol (Oxf) 1997; 46: 21-27
38. Toogood AA, Beardwell CG, Shalet SM. The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clin Endocrinol (Oxf) 1994; 41: 511-516
39. Putignano P, Dubini A, Toja P, Invitti C, Bonfanti S, Redaelli G, Zappulli D, Cavagnini F. Salivary cortisol measurement in normal-weight, obese and anorexic women: comparison with plasma cortisol. Eur J Endocrinol 2001; 145: 165-171
40. Liu H, Bravata DM, Cabaccan J, Raff H, Ryzen E. Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans. Clin Endocrinol (Oxf) 2005; 63: 642-649
41. Suri D, Moran J, Hibbard JU, Kasza K, Weiss RE. Assessment of adrenal reserve in pregnancy: defining the normal response to the adrenocorticotropin stimulation test. J Clin Endocrinol Metab 2006; 91: 3866-3872 (Pubitemid 44536856)
42. Thomson AH, Devers MC, Wallace AM, Grant D, Campbell K, Freel M, Connell JM. Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clin Endocrinol (Oxf) 2007; 66: 789-796 (Pubitemid 47024263)