Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae

Genetics

Volumn 183, Issue 2, 2009, Pages 529-538

  Saint Marc, Christelle ^a,b   Pinson, Benoît ^a,b   Coulpier, Fanny ^c   Jourdren, Laurent ^c   Lisova, Olesia ^a,b   Daignan Fornier, Bertrand ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Institut de Biochimie et Genetique Cellulaires   (France)

^c ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE MONOPHOSPHATE DEAMINASE; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; NUCLEOTIDE; PURINE; THREONINE; TRANSCRIPTOME;

ARTICLE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME METABOLISM; GENE OVEREXPRESSION; IN VIVO STUDY; METABOLISM; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; UPREGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 70649100410     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.109.105858     Document Type: Article

References (41)

1. BENGTSSON, H., G. JONSSON and J. VALLON-CHRISTERSSON, 2004 Calibration and assessment of channel-specific biases in microarray data with extended dynamical range. BMC Bioinformatics 5: 177.
2. BRETON, A., B. PINSON, F. COULPIER, M. F. GIRAUD, A. DAUTANT et al., 2008 Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants. Genetics 178: 815-824.
3. DAIGNAN-FORNIER, B., and G. R. FINK, 1992 Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2. Proc. Natl. Acad. Sci. USA 89: 6746-6750.
4. DESMOUCELLES, C., B. PINSON, C. SAINT-MARC and B. DAIGNAN-FORNIER, 2002 Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. J. Biol. Chem. 277: 27036-27044.
5. DUENAS, E., C. R. VAZQUEZ DE ALDANA, T. DE COS, C. CASTRO and M. HENAR VALDIVIESO, 1999 Generation of null alleles for the functional analysis of six genes from the right arm of Saccharomyces cerevisiae chromosome II. Yeast 15: 615-623. (Pubitemid 29221677)
6. ESCOBAR-HENRIQUES, M., and B. DAIGNAN-FORNIER, 2001 Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J. Biol. Chem. 276: 1523-1530.
7. ESCOBAR-HENRIQUES, M., A. BALGUERIE, C. MONRIBOT, H. BOUCHERIE and B. DAIGNAN-FORNIER, 2001 Proteome analysis and morphological studies reveal multiple effects of the immunosuppressive drug mycophenolic acid specifically resulting from guanylic nucleotide depletion. J. Biol. Chem. 276: 46237-46242.
8. FISHBEIN, W. N., V. W. ARMBRUSTMACHER and J. L. GRIFFIN, 1978 Myoadenylate deaminase deficiency: a new disease of muscle. Science 200: 545-548. (Pubitemid 8328387)
9. GARI, E., L. PIEDRAFITA, M. ALDEA and E. HERRERO, 1997 A set of vectors with a tetracycline-regulatable promoter system for modulated gene expression in Saccharomyces cerevisiae. Yeast 13: 837-848.
10. GAUTHIER, S., F. COULPIER, L. JOURDREN, M. MERLE, S. BECK et al., 2008 Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. Mol. Microbiol. 68: 1583-1594.
11. GHAEMMAGHAMI, S., W. K. HUH, K. BOWER, R. W. HOWSON, A. BELLE et al., 2003 Global analysis of protein expression in yeast. Nature 425: 737-741. (Pubitemid 37314318)
12. GIAEVER, G., A. M. CHU, L. NI, C. CONNELLY, L. RILES et al., 2002 Functional profiling of the Saccharomyces cerevisiae genome. Nature 418: 387-391.
13. HARTMAN, J. L., IV, 2007 Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism. Proc. Natl. Acad. Sci. USA 104: 11700-11705.
14. HARTMAN, J. L., IV, and N. P. TIPPERY, 2004 Systematic quantification of gene interactions by phenotypic array analysis. Genome Biol. 5: R49.
15. HYLE, J. W., R. J. SHAW and D. REINES, 2003 Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J. Biol. Chem. 278: 28470-28478.
16. ITOH, R., C. SAINT-MARC, S. CHAIGNEPAIN, R. KATAHIRA, J. M. SCHMITTER et al., 2003 The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 59-nucleotidase. BMC Biochem. 4: 4.
17. JONES, E. W., and G. R. FINK, 1982 Regulation of amino acid and nucleotide biosynthesis in yeast, pp. 181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by J. N. STRATHERN, E. W. JONES and J. R. BROACH. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. KIPPERT, F., 1995 A rapid permeabilization procedure for accurate quantitative determination of beta-galactosidase activity in yeast cells. FEMS Microbiol. Lett. 128: 201-206.
19. KROGAN, N. J., G. CAGNEY, H. YU, G. ZHONG, X. GUO et al., 2006 Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440: 637-643.
20. LECOQ, K., I. BELLOC, C. DESGRANGES, M. KONRAD and B. DAIGNAN-FORNIER, 2001 YLR209c encodes Saccharomyces cerevisiae purine nucleoside phosphorylase. J. Bacteriol. 183: 4910-4913.
21. LORET, M. O., L. PEDERSEN and J. FRANCOIS, 2007 Revised procedures for yeast metabolites extraction: application to a glucose pulse to carbon-limited yeast cultures, which reveals a transient activation of the purine salvage pathway. Yeast 24: 47-60.
22. MASON, P. B., and K. STRUHL, 2005 Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. Mol. Cell 17: 831-840.
23. MERKLER, D. J., and V. L. SCHRAMM, 1990 Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism. J. Biol. Chem. 265: 4420-4426.
24. MERKLER, D. J., and V. L. SCHRAMM, 1993 Catalytic mechanism of yeast adenosine 5′-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects. Biochemistry 32: 5792-5799.
25. MERKLER, D. J., A. S. WALI, J. TAYLOR and V. L. SCHRAMM, 1989 AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme. J. Biol. Chem. 264: 21422-21430.
26. MERKLER, D. J., P. C. KLINE, P. WEISS and V. L. SCHRAMM, 1993 Transition-state analysis of AMP deaminase. Biochemistry 32: 12993-13001.
27. MEYER, S. L., K. L. KVALNES-KRICK and V. L. SCHRAMM, 1989 Characterization of AMD, the AMP deaminase gene in yeast. Production of amd strain, cloning, nucleotide sequence, and properties of the protein. Biochemistry 28: 8734-8743.
28. NATARAJAN, K., M. R. MEYER, B. M. JACKSON, D. SLADE, C. ROBERTS et al., 2001 Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell. Biol. 21: 4347-4368.
29. OSORIO, H., E. CARVALHO, M. DEL VALLE, M. A. GUNTHER SILLERO, P. MORADAS-FERREIRA et al., 2003 H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae. An experimental and theoretical approach. Eur. J. Biochem. 270: 1578-1589.
30. REBORA, K., C. DESMOUCELLES, F. BORNE, B. PINSON and B. DAIGNAN-FORNIER, 2001 Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Mol. Cell. Biol. 21: 7901-7912.
31. REBORA, K., B. LALOO and B. DAIGNAN-FORNIER, 2005 Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. Genetics 170: 61-70.
32. RIBARD, C., M. ROCHET, B. LABEDAN, B. DAIGNAN-FORNIER, P. ALZARI et al., 2003 Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family. J. Mol. Biol. 334: 1117-1131.
33. ROLFES, R. J., and A. G. HINNEBUSCH, 1993 Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol. Cell. Biol. 13: 5099-5111.
34. SABINA, R. L., and D. K. MAHNKE-ZIZELMAN, 2000 Towards an understanding of the functional significance of N-terminal domain divergence in human AMP deaminase isoforms. Pharmacol. Ther. 87: 279-283.
35. SCHMIDT, R., M. F. MANOLSON and M. R. CHEVALLIER, 1984 Photoaffinity labeling and characterization of the cloned purine-cytosine transport system in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 81: 6276-6280.
36. SHAW, R. J., and D. REINES, 2000 Saccharomyces cerevisiae transcription elongation mutants are defective in PUR5 induction in response to nucleotide depletion. Mol. Cell. Biol. 20: 7427-7437.
37. SHEMER, R., A. MEIMOUN, T. HOLTZMAN and D. KORNITZER, 2002 Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5. Mol. Cell. Biol. 22: 5395-5404.
38. SHERMAN, F., G. R. FINK and J. B. HICKS, 1986 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
39. SILLES, E., H. OSORIO, R. MAIA, M. A. GUNTHER SILLERO and A. SILLERO, 2005 Micromolar HgCl2 concentrations transitorily duplicate the ATP level in Saccharomyces cerevisiae cells. FEBS Lett. 579: 4044-4048.
40. VANDENBOL, M., and D. PORTETELLE, 1999 Disruption of six ORFs on Saccharomyces cerevisiae chromosome X: the YJL069c gene of unknown function is essential to cell viability. Yeast 15: 1411-1417. (Pubitemid 29445814)
41. XU, J., H. Y. ZHANG, C. H. XIE, H. W. XUE, P. DIJKHUIS et al., 2005 EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis. Plant J. 42: 743-756.