Sleep apnea is an independent correlate of erectile and sexual dysfunction

Journal of Sexual Medicine

Volumn 6, Issue 11, 2009, Pages 3147-3157

  Budweiser, Stephan ^a   Enderlein, Stefan ^a   Jörres, Rudolf A ^b   Hitzl, Andre P ^a   Wieland, Wolf F ^c   Pfeifer, Michael ^c   Arzt, Michael ^c  

^a Donaustauf Hospital   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Endothelial dysfunction; Obstructive sleep apnea hypopnea syndrome; Oxidative stress; Risk factors; Sexual function; Sleep apnea

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE SEVERITY; ERECTILE DYSFUNCTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; OBESITY; ORGASM; OXYGEN SATURATION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; POLYSOMNOGRAPHY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE SURGERY; QUESTIONNAIRE; RISK FACTOR; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SEXUAL SATISFACTION; SLEEP APNEA SYNDROME;

EID: 70649094522     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01372.x     Document Type: Article

References (50)

1. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: A population health perspective. Am J Respir Crit Care Med 2002, 165:1217-39.
2. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study. Lancet 2005, 365:1046-53.
3. Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 2005, 172:1447-51.
4. Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med 2007, 120:151-7.
5. Jankowski JT, Seftel AD, Strohl KP. Erectile dysfunction and sleep related disorders. J Urol 2008, 179:837-41.
6. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, Somers VK. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000, 102:2607-10.
7. Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC, Lam WK. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000, 162:2166-71.
8. Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest 1991, 88:1054-7.
9. Phillips BG, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME, Somers VK. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999, 17:61-6.
10. Goncalves MA, Guilleminault C, Ramos E, Palha A, Paiva T. Erectile dysfunction, obstructive sleep apnea syndrome and nasal CPAP treatment. Sleep Med 2005, 6:333-9.
11. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lucke C, Mayer K, Olschewski H, Seeger W, Grimminger F. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: Response to CPAP therapy. Thorax 2000, 55:1046-51.
12. Lattimore JL, Wilcox I, Skilton M, Langenfeld M, Celermajer DS. Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation. Thorax 2006, 61:491-5.
13. Margel D, Cohen M, Livne PM, Pillar G. Severe, but not mild, obstructive sleep apnea syndrome is associated with erectile dysfunction. Urology 2004, 63:545-9.
14. Hirshkowitz M, Karacan I, Arcasoy MO, Acik G, Narter EM, Williams RL. Prevalence of sleep apnea in men with erectile dysfunction. Urology 1990, 36:232-4.
15. Heruti R, Shochat T, Tekes-Manova D, Ashkenazi I, Justo D. Association between erectile dysfunction and sleep disorders measured by self-assessment questionnaires in adult men. J Sex Med 2005, 2:543-50.
16. Zias N, Bezwada V, Gilman S, Chroneou A. Obstructive sleep apnea and erectile dysfunction: Still a neglected risk factor?. Sleep Breath 2009, 13:3-10.
17. Bloch KE, Schoch OD, Zhang JN, Russi EW. German version of the Epworth sleepiness scale. Respiration 1999, 66:440-7.
18. Johns MW. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep 1991, 14:540-5.
19. Teloken PE, Smith EB, Lodowsky C, Freedom T, Mulhall JP. Defining association between sleep apnea syndrome and erectile dysfunction. Urology 2006, 67:1033-7.
20. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997, 49:822-30.
21. Sleep. 1999, 22:667-89.
22. Arzt M, Bradley TD. Treatment of sleep apnea in heart failure. Am J Respir Crit Care Med 2006, 173:1300-8.
23. Lue TF. Erectile dysfunction. N Engl J Med 2000, 342:1802-13.
24. Baumhakel M, Schlimmer N, Buyukafsar K, Arikan O, Bohm M. Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice. J Pharmacol Exp Ther 2008, 325:818-23.
25. Dusing R. Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men. Blood Press Suppl 2003, 2:29-34.
26. Fogari R, Preti P, Derosa G, Marasi G, Zoppi A, Rinaldi A, Mugellini A. Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men. Eur J Clin Pharmacol 2002, 58:177-80.
27. Llisterri JL, Lozano Vidal JV, Aznar VJ, Argaya RM, Pol BC, Sanchez Zamorano MA, Ferrario CM. Sexual dysfunction in hypertensive patients treated with losartan. Am J Med Sci 2001, 321:336-41.
28. Saltzman EA, Guay AT, Jacobson J. Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: A clinical observation. J Urol 2004, 172:255-8.
29. Solomon H, Samarasinghe YP, Feher MD, Man J, Rivas-Toro H, Lumb PJ, Wierzbicki AS, Jackson G. Erectile dysfunction and statin treatment in high cardiovascular risk patients. Int J Clin Pract 2006, 60:141-5.
30. Jackson G. Simvastatin and impotence. Br Med J 1997, 315:31.
31. Gazzaruso C, Solerte SB, Pujia A, Coppola A, Vezzoli M, Salvucci F, Valenti C, Giustina A, Garzaniti A. Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: A potential protective role for statins and 5-phosphodiesterase inhibitors. J Am Coll Cardiol 2008, 51:2040-4.
32. Soukhova-O'Hare GK, Shah ZA, Lei Z, Nozdrachev AD, Rao CV, Gozal D. Erectile dysfunction in a murine model of sleep apnea. Am J Respir Crit Care Med 2008, 178:644-50.
33. Fanfulla F, Malaguti S, Montagna T, Salvini S, Bruschi C, Crotti P, Casale R, Rampulla C. Erectile dysfunction in men with obstructive sleep apnea: An early sign of nerve involvement. Sleep 2000, 23:775-81.
34. Verratti V, Di Giulio C, Berardinelli F, Pellicciotta M, Di Francesco S, Iantorno R, Nicolai M, Gidaro S, Tenaglia R. The role of hypoxia in erectile dysfunction mechanisms. Int J Impot Res 2007, 19:496-500.
35. Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, Lavie P. Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. J Clin Endocrinol Metab 2002, 87:3394-8.
36. Koseoglu N, Koseoglu H, Itil O, Oztura I, Baklan B, Ikiz AO, Esen AA. Sexual function status in women with obstructive sleep apnea syndrome. J Sex Med 2007, 4:1352-7.
37. Onem K, Erol B, Sanli O, Kadioglu P, Yalin AS, Canik U, Cuhadaroglu C, Kadioglu A. Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study. J Sex Med 2008, 5:2600-9.
38. Rakugi H, Tabuchi Y, Nakamaru M, Nagano M, Higashimori K, Mikami H, Ogihara T, Suzuki N. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia. Biochem Biophys Res Commun 1990, 169:973-7.
39. Yamauchi M, Kimura H. Oxidative stress in obstructive sleep apnea: Putative pathways to the cardiovascular complications. Antioxid Redox Signal 2008, 10:755-68.
40. Savransky V, Nanayakkara A, Li J, Bevans S, Smith PL, Rodriguez A, Polotsky VY. Chronic intermittent hypoxia induces atherosclerosis. Am J Respir Crit Care Med 2007, 175:1290-7.
41. Lavie L. Oxidative stress-a unifying paradigm in obstructive sleep apnea and comorbidities. Prog Cardiovasc Dis 2009, 51:303-12.
42. Seftel AD, Strohl KP, Loye TL, Bayard D, Kress J, Netzer NC. Erectile dysfunction and symptoms of sleep disorders. Sleep 2002, 25:643-7.
43. Hanak V, Jacobson DJ, McGree ME, Sauver JS, Lieber MM, Olson EJ, Somers VK, Gades NM, Jacobsen SJ. Snoring as a risk factor for sexual dysfunction in community men. J Sex Med 2008, 5:898-908.
44. Perimenis P, Karkoulias K, Markou S, Gyftopoulos K, Athanasopoulos A, Barbalias G, Kiriazopoulou V, Spiropoulos K. Erectile dysfunction in men with obstructive sleep apnea syndrome: A randomized study of the efficacy of sildenafil and continuous positive airway pressure. Int J Impot Res 2004, 16:256-60.
45. Roizenblatt S, Guilleminault C, Poyares D, Cintra F, Kauati A, Tufik S. A double-blind, placebo-controlled, crossover study of sildenafil in obstructive sleep apnea. Arch Intern Med 2006, 166:1763-7.
46. Hoekema A, Stel AL, Stegenga B, van der Hoeven JH, Wijkstra PJ, van Driel MF, de Bont LG. Sexual function and obstructive sleep apnea-hypopnea: A randomized clinical trial evaluating the effects of oral-appliance and continuous positive airway pressure therapy. J Sex Med 2007, 4:1153-62.
47. Margel D, Tal R, Livne PM, Pillar G. Predictors of erectile function improvement in obstructive sleep apnea patients with long-term CPAP treatment. Int J Impot Res 2005, 17:186-90.
48. Morales A, Condra M, Reid K. The role of nocturnal penile tumescence monitoring in the diagnosis of impotence: A review. J Urol 1990, 143:441-6.
49. Tokatli Z, Akand M, Yaman O, Gulpinar O, Anafarta K. Comparison of international index of erectile function with nocturnal penile tumescence and rigidity testing in evaluation of erectile dysfunction. Int J Impot Res 2006, 18:186-9.
50. Wein AJ, Fishkin R, Carpiniello VL, Malloy TR. Expansion without significant rigidity during nocturnal penile tumescence testing: A potential source of misinterpretation. J Urol 1981, 126:343-4.