Interlaboratory variation in scoring dicentric chromosomes in a case of partial-body x-ray exposure: Implications for biodosimetry networking and cytogenetic "triage mode" scoring

Radiation Research

Volumn 172, Issue 6, 2009, Pages 746-752

  Ainsbury, E A ^a   Livingston, G K ^b   Abbott, M G ^b   Moquet, J E ^a   Hone, P A ^a   Jenkins, M S ^b   Christensen, D M ^b   Lloyd, D C ^a   Rothkamm, K ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BIODOSIMETRY; CANCER RADIOTHERAPY; CASE REPORT; CLINICAL LABORATORY; DICENTRIC CHROMOSOME; DOSIMETRY; EMERGENCY HEALTH SERVICE; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; OBSERVER VARIATION; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SCORING SYSTEM; VALIDATION PROCESS;

CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; HUMANS; RADIATION DOSAGE; X-RAYS;

EID: 70549109319     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1934.1     Document Type: Article

References (15)

1. M. A. Bender and P. C. Gooch, Persistent chromosome aberrations in irradiated human subjects. Radiat. Res. 16, 44-53 (1962).
2. IAEA, Cytogenetic Analysis for Radiation Dose Assessment: A Manual. Technical Reports Series No. 405, International Atomic Energy Agency, Vienna, 2001.
3. K. Rothkamm, S. Balroop, J. Shekhdar, P. Fernie and V. Goh, Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure. Radiology 242, 244-251 (2007).
4. W. F. Blakely, Z. Carr, M. C-M. Chu, R. Dayal-Drager, K. Fujimoto, M. Hopmeir, U. Kulka, P. Lillis-Hearne, G. K. Livingston and M. A. Yoshida, WHO 1st consultation on the development of a global biodosimetry laboratories network for radiation emergencies (BioDoseNet). Radiat. Res. 171, 127-139 (2009).
5. IAEA, IAEA Response Assistance Network Incident and Emergency Centre. EPR-RANET Technical Document, International Atomic Energy Agency, Vienna, 2006.
6. C. Lindholm, H. Romm, G. Stephan, E. Schmid, J. Moquet and A. Edwards, Intercomparison of translocation and dicentric frequencies between laboratories in a follow-up of the radiological accident in Estonia. Int. J. Radiat. Biol. 78, 883-890 (2002).
7. L. Roy, V. Buard, M. Delbos, V. Durand, N. Paillole, E. Grégoire and P. Voisin, International intercomparison for criticality dosimetry: the case of biological dosimetry. Radiat. Prot. Dosimetry 110, 471-476 (2004).
8. R. C. Wilkins, H. Romm, T. Kao, A. A. Awa, M. A. Yoshida, G. K. Livingston, M. S. Jenkins, U. Oestreicher, T. C. Pellmar and P. G. S. Prasanna, Interlaboratory comparison of the dicentric chromosome assay for radiation biodosimetry in mass casualty events. Radiat. Res. 169, 551-560 (2008).
9. L. Roy, S. Roch-Lefevre, A. Vaurijoux, P. Voisin, C. Martin, E. Grégoire and P. Voisin, Optimization of cytogenetic procedures for population triage in case of radiological emergency. Radiat. Meas. 42, 1143-1146 (2007).
10. J. Deperas, M. Szluinska, M. Deperas-Kaminska, A. Edwards, D. Lloyd, C. Lindholm, H. Romm, L. Roy, R. Moss, J. Morand and A. Wojcik, Cabas: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry. Radiat. Prot. Dosimetry 124, 115-123 (2007).
11. D. Lea and D. Catcheside, The mechanism of the induction by radiation of chromosome aberrations in Tradescantia. J. Genet. 44, 216-245 (1942).
12. G. Dolphin, Biological dosimetry with particular reference to chromosome aberrations analysis. A review of methods. In Proceedings of the International Symposium: Handling of Radiation Accidents, pp. 215-224. IAEA, Vienna, 1969.
13. D. Lloyd, A. Edwards and J. Prosser, Chromosome aberrations induced in human lymphocytes by in vitro acute x and gamma radiation. Radiat. Prot. Dosimetry 15, 83-88 (1986). (Pubitemid 17185697)
14. J. E. Moquet, A. A. Edwards, D. C. Lloyd and P. Hone, The use of FISH chromosome painting for assessment of old doses of ionising radiation. Radiat. Prot. Dosimetry 88, 27-33 (2000).
15. D. C. Lloyd, A. A. Edwards, J. E. Moquet and Y. C. Guerrero-Carbajal, The role of cytogenetics in early triage of radiation casualties. Appl. Radiat. Isot. 52, 1107-1112 (2000).