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Relaix, F.1
Buckingham, M.2
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D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm
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The authors identified a novel gene acting in the specification of ventral mesoderm in Drosophila, D-six4. Mutant embryos show severe disruption of ventral and lateral muscles. These results are highly similar to what was observed for eya (see ref. [30]) and extend the well-established role of Eya-Six proteins in vertebrate myogenesis to invertebrates.
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Clark I.B., Boyd J., Hamilton G., Finnegan D.J., and Jarman A.P. D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm. Dev Biol 294 (2006) 220-231. The authors identified a novel gene acting in the specification of ventral mesoderm in Drosophila, D-six4. Mutant embryos show severe disruption of ventral and lateral muscles. These results are highly similar to what was observed for eya (see ref. [30]) and extend the well-established role of Eya-Six proteins in vertebrate myogenesis to invertebrates.
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Dev Biol
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Clark, I.B.1
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A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm
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This study identified EYA-1 and CEH-34 (CeSix), members of conserved Eya and Six TF families, respectively, as key regulators of non-muscle cell fate during C. elegans body wall muscle development. Both factors have common upstream regulators and upon misexpression are able to induce cell fate to the non-muscle lineage. These findings highlight an unexpected, more ancestral role of the Eya-Six TFs in myogenesis.
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Amin N.M., Lim S.E., Shi H., Chan T.L., and Liu J. A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. Dev Biol (2009). This study identified EYA-1 and CEH-34 (CeSix), members of conserved Eya and Six TF families, respectively, as key regulators of non-muscle cell fate during C. elegans body wall muscle development. Both factors have common upstream regulators and upon misexpression are able to induce cell fate to the non-muscle lineage. These findings highlight an unexpected, more ancestral role of the Eya-Six TFs in myogenesis.
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(2009)
Dev Biol
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Amin, N.M.1
Lim, S.E.2
Shi, H.3
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MEF2: a central regulator of diverse developmental programs
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Potthoff M.J., and Olson E.N. MEF2: a central regulator of diverse developmental programs. Development 134 (2007) 4131-4140
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Potthoff, M.J.1
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A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation
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Penn B.H., Bergstrom D.A., Dilworth F.J., Bengal E., and Tapscott S.J. A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. Genes Dev 18 (2004) 2348-2353
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Penn, B.H.1
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mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo
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Dodou E., Xu S.M., and Black B.L. mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo. Mech Dev 120 (2003) 1021-1032
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Dodou, E.1
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The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis
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Cripps, R.M.1
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48
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Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
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Molkentin J.D., Black B.L., Martin J.F., and Olson E.N. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83 (1995) 1125-1136
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Molkentin, J.D.1
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Olson, E.N.4
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49
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Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila
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This study identifies CF2 as a new factor that synergistically actives the actin57B enhancer together with Mef2. A similar cooperative activity between CF2 and Mef2 regulates enhancers of other muscle structural genes, suggesting that CF2 may act as a more general co-activator of Mef2 activity during late stages of development.
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Tanaka K.K., Bryantsev A.L., and Cripps R.M. Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila. Mol Cell Biol 28 (2008) 1616-1629. This study identifies CF2 as a new factor that synergistically actives the actin57B enhancer together with Mef2. A similar cooperative activity between CF2 and Mef2 regulates enhancers of other muscle structural genes, suggesting that CF2 may act as a more general co-activator of Mef2 activity during late stages of development.
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Tanaka, K.K.1
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Cripps, R.M.3
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50
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63049083213
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Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster
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This paper establishes Drosophila Vestigial and Scalloped proteins as direct interaction partners of Mef2 in the developing body wall and cardiac muscle. Ectopic expression of either vestigial or scalloped blocks muscle differentiation.
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Deng H., Hughes S.C., Bell J.B., and Simmonds A.J. Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster. Mol Biol Cell 20 (2009) 256-269. This paper establishes Drosophila Vestigial and Scalloped proteins as direct interaction partners of Mef2 in the developing body wall and cardiac muscle. Ectopic expression of either vestigial or scalloped blocks muscle differentiation.
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Mol Biol Cell
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Deng, H.1
Hughes, S.C.2
Bell, J.B.3
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Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation
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Maeda T., Chapman D.L., and Stewart A.F. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. J Biol Chem 277 (2002) 48889-48898
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Maeda, T.1
Chapman, D.L.2
Stewart, A.F.3
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52
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34547882766
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The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila
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This study shows that Him prevents premature activation of late myogenic genes by counteracting Mef2 activity during early stages of myogenesis. Prolonged expression of Him leads to a failure in muscle differentiation that can be partially rescued by increasing Mef2 levels, suggesting that the balance between the levels of these two factors is essential for muscle differentiation.
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Liotta D., Han J., Elgar S., Garvey C., Han Z., and Taylor M.V. The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila. Curr Biol 17 (2007) 1409-1413. This study shows that Him prevents premature activation of late myogenic genes by counteracting Mef2 activity during early stages of myogenesis. Prolonged expression of Him leads to a failure in muscle differentiation that can be partially rescued by increasing Mef2 levels, suggesting that the balance between the levels of these two factors is essential for muscle differentiation.
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Curr Biol
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Liotta, D.1
Han, J.2
Elgar, S.3
Garvey, C.4
Han, Z.5
Taylor, M.V.6
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53
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The Him gene inhibits the development of Drosophila flight muscles during metamorphosis
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Similar to the embryonic function of Him, the authors demonstrate that Him is necessary to antagonize the activity of Mef2, and hence prevent untimely differentiation during adult muscle development as well. A novel aspect is the positive regulation of Him by Notch signalling, thereby identifying a new mechanism of Notch-mediated inhibition of differentiation.
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Soler C., and Taylor M.V. The Him gene inhibits the development of Drosophila flight muscles during metamorphosis. Mech Dev (2009). Similar to the embryonic function of Him, the authors demonstrate that Him is necessary to antagonize the activity of Mef2, and hence prevent untimely differentiation during adult muscle development as well. A novel aspect is the positive regulation of Him by Notch signalling, thereby identifying a new mechanism of Notch-mediated inhibition of differentiation.
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Mech Dev
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Soler, C.1
Taylor, M.V.2
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54
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mef2 activity levels differentially affect gene expression during Drosophila muscle development
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Using an allelic series of Mef2 mutants, the authors show that different Mef2 downstream target genes require different levels of Mef2 activity for their expression. Interestingly, this is somewhat correlated with the onset of the genes' expression, where late muscle differentiation genes are dependent on high levels of Mef2 for their expression.
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Elgar S.J., Han J., and Taylor M.V. mef2 activity levels differentially affect gene expression during Drosophila muscle development. Proc Natl Acad Sci U S A 105 (2008) 918-923. Using an allelic series of Mef2 mutants, the authors show that different Mef2 downstream target genes require different levels of Mef2 activity for their expression. Interestingly, this is somewhat correlated with the onset of the genes' expression, where late muscle differentiation genes are dependent on high levels of Mef2 for their expression.
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Proc Natl Acad Sci U S A
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Elgar, S.J.1
Han, J.2
Taylor, M.V.3
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