Regulation of biofilm formation by σB is a common mechanism in Staphylococcus epidermidis and is not mediated by transcriptional regulation of sarA

International Journal of Artificial Organs

Volumn 32, Issue 9, 2009, Pages 584-591

  Jäger, Sebastien ^a   Jonas, Beate ^b   Pfanzelt, Dorothea ^c   Horstkotte, Matthias A ^d   Rohde, Holger ^c   Mack, Dietrich ^e   Knobloch, Johannes K M ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d Biocentia   (Germany)

^e SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Alternative sigma factor; Biofilm; IcaADBC; Polysaccharide intercellular adhesin; sarA; Sigma B; Staphylococcus epidermidis

Indexed keywords

TRANSCRIPTION;

ALTERNATIVE SIGMA FACTOR; BIOFILM FORMATION; EPIDERMIDIS; ICAADBC; POLYSACCHARIDE INTERCELLULAR ADHESIN; S. AUREUS; SIGMA B; SIGMA FACTOR; STAPHYLOCOCCUS ACCESSORY REGULATOR; STAPHYLOCOCCUS EPIDERMIDIS;

BIOFILMS;

BACTERIAL PROTEIN; ICAA PROTEIN; SIGMA FACTOR; SIGMA FACTOR B; SMAD ANCHOR FOR RECEPTOR ACTIVATION; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOFILM; CONTROLLED STUDY; DOWN REGULATION; NONHUMAN; PHENOTYPIC VARIATION; PROMOTER REGION; REGULATORY MECHANISM; STAPHYLOCOCCUS EPIDERMIDIS; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 70549095847     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880903200907     Document Type: Article

References (43)

1. Götz F. Staphylococcus and biofilms. Mol Microbiol 2002; 43: 1367-78.
2. Mack D, Rohde H, Harris LG, Davies AP, Horstkotte MA, Knobloch JKM. Biofilm formation in medical device-related infection. Int J Artif Organs 2006; 29: 343-59.
3. Mack D, Davies AP, Harris LG, Knobloch JKM, Rohde H. Staphylococcus epidermidis biofilms: functional molecules, relation to virulence, and vaccine potential. Top Curr Chem 2009; 288: 157-82.
4. Knobloch JKM, von Osten H, Horstkotte MA, Rohde H, Mack D. Minimal attachment killing (MAK): a versatile method for susceptibility testing of attached biofilm-positive and -negative Staphylococcus epidermidis. Med Microbiol Immunol (Berl) 2002; 191: 107-14.
5. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284: 1318-22.
6. Knobloch JKM, Von OH, Horstkotte MA, Rohde H, Mack D. Biofilm formation is not necessary for development of quinolone-resistant "persister" cells in an attached Staphylococcus epidermidis population. Int J Artif Organs 2008; 31: 752-60.
7. Frebourg NB, Lefebvre S, Baert S, Lemeland JF. PCR-Based assay for discrimination between invasive and contaminating Staphylococcus epidermidis strains. J Clin Microbiol 2000; 38: 877-80.
8. Rohde H, Kalitzky M, Kröger N, Scherpe S, Horstkotte MA, Knobloch JKM, Zander AR, Mack D. detection of virulence-associated genes does not discriminate between invasive and commensal Staphylococcus epidermidis strains from a bone marrow transplant unit. J Clin Microbiol 2004; 42: 5614-9.
9. Knobloch JKM, Horstkotte MA, Rohde H, Kaulfers PM, Mack D. Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis. J Antimicrob chemother 2002; 49: 683-7.
10. Cotter JJ, O'Gara JP, Mack D, Casey E. Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis. Appl Environ Microbiol 2009; 75: 261-4.
11. Knobloch JKM, Bartscht K, Sabottke A, Rohde H, Feucht HH, Mack D. Biofilm formation by Staphylococcus epidermidis depends on functional RsbU, an activator of the sigB operon: differential activation mechanisms due to ethanol and salt stress. J Bacteriol 2001; 183: 2624-33.
12. Rachid S, Cho S, Ohlsen K, Hacker J, Ziebuhr W. Induction of Staphylococcus epidermidis biofilm formation by environmental factors: the possible involvement of the alternative transcription factor sigB. Adv Exp Med Biol 2000; 485: 159-66.
13. Rachid S, Ohlsen K, Witte W, Hacker J, Ziebuhr W. Effect of subinhibitory antibiotic concentrations on polysaccharide intercellular adhesin expression in biofilm-forming Staphylococcus epidermidis. Antimicrob Agents chemother 2000; 44: 3357-63.
14. Cramton SE, Ulrich M, Götz F, Döring G. Anaerobic conditions induce expression of polysaccharide intercellular adhesin in Staphylococcus aureus and Staphylococcus epidermidis. Infect Immun 2001; 69: 4079-85.
15. Dobinsky S, Kiel K, Rohde H, Bartscht K, Knobloch JKM, Horstkotte MA, Mack D. Glucose-Related Dissociation between icaADBC Transcription and Biofilm Expression by Staphylococcus epidermidis: Evidence for an Additional Factor required for Polysaccharide Intercellular Adhesin Synthesis. J Bacteriol 2003; 185: 2879-86.
16. Conlon KM, Humphreys H, O'Gara JP. icaR Encodes a Transcriptional Repressor Involved in Environmental Regulation of ica Operon Expression and Biofilm Formation in Staphylococcus epidermidis. J Bacteriol 2002; 184: 4400-8.
17. Conlon KM, Humphreys H, O'Gara JP. Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis. J Bacteriol 2004; 186: 6208-19.
18. B. Appl Environ Microbiol 2005; 71: 5577-81.
19. Ziebuhr W, Krimmer V, Rachid S, Lossner I, Götz F, Hacker J. A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256. Mol Microbiol 1999; 32: 345-56.
20. B by repression of the negative regulator gene icaR. Infect Immun 2004; 72: 3838-48.
21. Tormo MA, Marti M, Valle J, Manna AC, Cheung AL, Lasa I, Penades JR. SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development. J Bacteriol 2005; 187: 2348-56.
22. B and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis. Can J Microbiol 2007; 53: 82-91.
23. Cramton SE, Gerke C, Schnell NF, Nichols WW, Götz F. The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation. Infect Immun 1999; 67: 5427-33.
24. Knobloch JKM, Horstkotte MA, Rohde H, Mack D. Evaluation of different detection methods of biofilm formation in Staphylococcus aureus. Med Microbiol Immunol (Berl) 2002; 191: 101-6.
25. B is essential for biofilm development by Staphylococcus aureus. Mol Microbiol 2003; 48: 1075-87.
26. Dobinsky S, Rohde H, Knobloch JKM, Horstkotte MA, Mack D. Transcriptional activity of icaADBC is not correlated to the degree of biofilm formation in clinical ica-positive Staphylococcus epidermidis strains. Biofilms 2004; 1: 101-6.
27. B is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate. J Bacteriol 2000; 182: 6824-6.
28. Lauderdale KJ, Boles BR, Cheung AL, Horswill AR. Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect Immun 2009; 77: 1623-35.
29. Fluckiger U, Wolz C, Cheung AL. characterization of a sar homolog of Staphylococcus epidermidis. Infect Immun 1998; 66: 2871-8.
30. Christensen GD, Simpson WA, Younger JJ, Baddour LM, Barrett FF, Melton DM, Beachey EH. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol 1985; 22: 996-1006.
31. Mack D, Bartscht K, Fischer C, Rohde H, De Grahl C, Dobinsky S, Horstkotte MA, Kiel K, Knobloch JKM. Genetic and biochemical analysis of Staphylococcus epidermidis biofilm accumulation. Methods Enzymol 2001; 336: 215-39.
32. Wisplinghoff H, Rosato AE, Enright MC, Noto M, Craig W, Archer GL. Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates. Antimicrob Agents chemother 2003; 47: 3574-9.
33. Kozitskaya S, Olson ME, Fey PD, Witte W, Ohlsen K, Ziebuhr W. Clonal Analysis of Staphylococcus epidermidis Isolates carrying or Lacking Biofilm-Mediating Genes by Multilocus Sequence Typing. J Clin Microbiol 2005; 43: 4751-7.
34. Feil EJ, Li BC, Aanensen DM, Hanage WP, Spratt BG. eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J Bacteriol 2004; 186: 1518-30.
35. Method. Methods 2001; 25: 402-8.
36. Thomas JC, Vargas MR, Miragaia M, Peacock SJ, Archer GL, Enright MC. Improved multilocus sequence typing scheme for Staphylococcus epidermidis. J Clin Microbiol 2007; 45: 616-9.
37. B-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis. Antimicrob Agents chemother 2005; 49: 1216-9.
38. B-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains. Mol Gen Genet 1999; 261: 558-66.
39. B in response to environmental signals. J Bacteriol 1995; 177: 123-33.
40. B factor from Bacillus anthracis and its role in virulence. J Bacteriol 2000; 182: 5036-45.
41. B of Bacillus cereus: response to stress and role in heat adaptation. J Bacteriol 2004; 186: 316-25.
42. Mack D, Siemssen N, Laufs R. Parallel induction by glucose of adherence and a polysaccharide antigen specific for plastic-adherent Staphylococcus epidermidis: evidence for functional relation to intercellular adhesion. Infect Immun 1992; 60: 2048-57.
43. Nedelmann M, Sabottke A, Laufs R, Mack D. Generalized transduction for genetic linkage analysis and transfer of transposon insertions in different Staphylococcus epidermidis strains. Zentralbl Bakteriol 1998; 287: 85-92.