Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis

Journal of Clinical Biochemistry and Nutrition

Volumn 45, Issue 3, 2009, Pages 292-303

  Matsuoka, Shunichi ^a   Matsumura, Hiroshi ^a   Nakamura, Hitomi ^a   Oshiro, Shu ^a   Arakawa, Yasuo ^a   Hayashi, Junpei ^a   Sekine, Naoki ^a   Nirei, Kazushige ^a   Yamagami, Hiroaki ^a   Ogawa, Masahiro ^a   Nakajima, Noriko ^a   Amaki, Shuichi ^a   Tanaka, Naohide ^a   Moriyama, Mitsuhiko ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic hepatitis C; Hepatocellular carcinoma (HCC); Liver cirrhosis; Polaprezinc; Zinc supplementation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; POLAPREZINC; ZINC;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HEPATITIS C; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; TREATMENT OUTCOME; ZINC BLOOD LEVEL;

HEPATITIS C VIRUS;

EID: 70549088924     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.jcbn08-246     Document Type: Article

References (33)

1. AMA Department of Foods and Nutrition: Guidline for essential trace element preparations for parental use. JAMA, 241, 2051-2054, 1979.
2. Evans, G.W.: Zinc absorption and transport. In trace elements in Human Health and Disease, in Zinc and Copper, ed. By Prassd, A.S., Academic Press, New York, Vol.1, 1976.
3. Dibley, M.J.: Pres in Nutrition, Kenpakusha, Tokyo, Eighteen Edition, p. 344-345, 2002.
4. Krebs, N.F.: Overview of zinc absorption and excretion in the human gastrointestinal tract. J. Nutr., 130(5S Suppl), 1374S-1377S, 2000.
5. Takagi, H., Nagamine, T., Abe, T., Takayama, H., Sato, K., Otsuka, T., Kakizaki, S., Hashimoto, Y., Matsumoto, T., Kojima, A., Takezawa, J., Suzuki, K., Sato, S., and Mori, M.: Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J. Viral. Hepat., 8, 367-371, 2001.
6. Ebara, M., Fukuda, H., Hatano, R., Yoshikawa, M., Sugiura, N., Saisho, H., Kondo, F., and Yukawa, M.: Metal contents in the liver of patients with chronic liver disease caused by hepatitis C virus. Reference to hepatocellular carcinoma. Oncology, 65, 323-330, 2003.
7. Riggio, O., Merli, M., Capocaccia, L., Caschera, M., Zullo, A., Pinto, G., Gaudio, E., Franchitto, A., Spagnoli, R., D'Aquilino, E., and et al.: Zinc supplementation reduce blood ammonia and increases liver Ornithin transcarbamirase activity in experimental cirrhosis. Hepatology, 16, 785-789, 1992.
8. Nandi, S.S., Chawla, Y.K., Nath, R., and Dilawari, J.B.: Serum and urinary zinc in fulminant hepatic failure. J. Gastroenterol. Hepatol., 4, 209-213, 1989.
9. Yoshida, Y., Higashi, T., Nouso, K., Nakatsukasa, H., Nakamura, S.I., Watanabe, A., and Tsuji, T.: Effects of zinc deficiency/zinc supplementation on ammonia metabolism in patients with decompensated liver cirrhosis. Acta. Med. Okayama, 55, 349-355, 2001.
10. Grüngreiff, K. and Reinhold, D.: Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency. Med. Hypotheses., 64, 316-317, 2005.
11. Marchesini, G., Fabbri, A., Bianchi, G., Brizi, M., and Zoli, M.: Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis. Hepatology, 23, 1084-1092, 1996. (Pubitemid 26137051)
12. Tellinghuisen, T.L., Marcotrigiano, J., Gorbalenya, A.E., and Rice, C.M.: The NS5A protein of hepatitis C virus is a zinc metalloprotein. J. Biol. Chem., 279, 48576-48587, 2004.
13. Coon, J.T. and Ernst, E.: Complementary and alternative therapies in the treatment of chronic hepatitis C: a systematic review. J. Hepatol., 40, 491-500, 2004. (Pubitemid 38230852)
14. Oka, S., Ogino, K., Matsuura, S., Yoshimura, S., Yamamoto, K., Okazaki, Y., Takemoto, T., Kato, N., and Uda, T.: Human serum immuno-reactive copper, zinc-superoxide dismutase assayed with an enzyme monoclonal immunosorbent in patients with digestive cancer. Clin. Chim. Acta., 182, 209-219, 1989.
15. Muranaka, H. and Kato, N.: Detection of serum zinc by atomic absorption spectrometry. Rinsho Byori, 17, 559-562, 1969 (in Japanese).
16. Okamoto, H., Sugiyama, Y., Okada, S., Kurai, K., Akahane, Y., Sugai, Y., Tanaka, T., Tanaka, T., Sato, K., Tsuda, F., Miyakawa, Y., and Mayumi, M.: Typing of hepatitis C virus by PCR with type-specific primers: application to clinical surveys and tracing infectious sources. J. Gen. Virol., 73, 673-679, 1992.
17. Simmonds, P., Alberti, A., Alter, H.J., Bonino, F., Bradley, D.W., Brechot, C., Brouwer, J.T., Chan, S.W., Chayama, K., Chen, D.S., Choo, Q.L., Colombo, M., Cuypers, H.T.M., Date, T., Dusheiko, GM., Esteban, J.I., Fay, O., Hadziyannis, SJ., Han, J., Hatzakis, A., Holmes, E.C., Hotta, H., Houghton, M., Irvine, B., Kohara, M., Kolberg, J.A., Kuo, G., Lau, J.Y.N., Lelie, P.N., Maertens, G., McOmish, F., Miyamura, T., Mizokami, M., Nomoto, A., Prince, A.M., Reesink, H.W., Rice, C., Roggendorf, M., Schalm, S.W., Shikata, T., Shimotohno, K., Stuyver, L., Trepo, C., Weiner, A., Yap, P.L., and Urdea, M.S.: A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology, 19, 1321-1324, 1994. (Pubitemid 24134259)
18. Boyett, J.D. and Sullivan, J.F.: Distribution of protein-bound zinc in normal and cirrhotic serum. Metabolism, 19, 148-157, 1970.
19. Boyett, J.D. and Sullivan, J.F.: Zinc and collagen content of cirrhotic liver. Am. J Dig. Dis., 15, 797-802, 1970.
20. Scholmerich, J., Becher, M.S., Kottgen, E., Rauch, N., Haussinger, D., Lohle, E., Vuilleumier, J.P., and Gerok, W.: The influence of portosystemic shunting on zinc and vitamin A metabolism in liver cirrhosis. Hepatogastroenterology, 30, 143-147, 1983.
21. Wakiyama, K., Arakawa, Y., Suzuki, T., Miyamoto, M., Matsuo, Y., Honda, T., Tomioka, E., Mano, M., Kigoshi, K., Sasaki, A., and Takeuchi, S.: A pathophysiological significance of trace metals in rats with experimental cirrhosis. Acta. Pathologica. Hepatica., 140, 1182-1183, 1986 (In Japanese).
22. Arakawa, Y., Moriyama, M., and Tanaka, N.: Hepatic Diseases and Trace Elements, Gatsukai jimu center, Osaka, Japan, pp. 1-30, 2003 (In Japanese).
23. Cabre, M., Camps, J., Paternain, J.L., Ferre, N., and Joven, J.: Time-course of changes in hepatic lipid peroxidation and glutathione metabolism in rats with carbon tetrachloride-induced cirrhosis. Clin. Exp. Pharmacol. Physiol., 27, 694-699, 2000.
24. Camps, J., Bargallo, T., Gimenez, A., Alie, S., Caballeria, J., Pares, A., Joven, J., Masana, L., and Rodes, J.: Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration. Clin. Sci. (Lond), 83, 695-700, 1992.
25. Bray, T. and Bettger, W.J.: The physiological role of zinc as an antioxidant. Free Radic. Biol. Med., 8, 281-291, 1990.
26. Yoshikawa, T., Naito, Y., Tanigawa, T., Yoneta, T., and Kondo, M.: The antioxidant properties of a novel zinc-carnocine chelate compound, N-(3-amino-propionyl)-L-histidine zinc. Biochim. Biophys. Acta, 1115, 15-22, 1991.
27. Yoshikawa, T.: Role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced by water-immersion restraint stress and burn stress in rats. J. Clin. Biochem. Nutr., 8, 227-234, 1990.
28. Yoshikawa, T., Naito, Y., and Tanigawa, T.: Effect of zinc-carnosine chelate compound (Z-103), a novel antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Free Radic. Res. Commun., 14, 289-296, 1991.
29. Shanker, A.H. and Prased, A.S.: Zinc and immune function: the biological basis of altered resistence to infection. Am. J. Clin. Nutr., 68, 447S-463S, 1998.
30. Ibs, K.H. and Rink, L.: Zinc-altered immune function. J. Nutr., 133, 1452S-1456S, 2003.
31. Ravaglia, G., Forti, P., Maioli, F., Bastagli, L., Facchini, A., Mariani, E., Savarino, L., Sassi, S., Cucinotta, D., and Lenaz, G.: Effect of micronutrient status on natural killer immune function in healthy free-living subjects aged>/=90 y. Am. J. Clin. Nutr., 71, 590-598, 2000.
32. Sazawal, S., Jalla, S., Mazumder, S., Sinha, A., Black, R.E., and Bhan, M.K.: Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children. Indian Pediatr., 34, 589-597, 1997. (Pubitemid 27328745)
33. Chandra, P.K.: Effect of vitamin and trace-ellement supplementation on immune responses and infection in elderly subjects. Lancet, 340, 1124-1127, 1992.