Synthesis of new hetero- and carbocyclic aromatic amides of glycyrrhizic acid as potential anti-HIV agents

Pharmaceutical Chemistry Journal

Volumn 43, Issue 7, 2009, Pages 383-388

  Kondratenko, R M ^b   Baltina, L A ^a,a   Plyasunova, O A ^c   Pokrovskii, A G ^c   Tolstikov, G A ^a  

^a BASHKIR STATE MEDICAL UNIVERSITY   (Russian Federation)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^c State Scientific Center   (Russian Federation)

Author keywords

Anti HIV activity; Glycyrrhizic acid; Hetero and carbocyclic amides; Synthesis

Indexed keywords

3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL 2 4 AMINO BENZOYLSULFAMIDO 4,6 DIMETHYLPYRIMIDINE)N BETA DEXTRO GLUCURONOPYRANOSYL 2 4 AMINOBENZOYLSULFAMIDO 4,6 DIMETHYLPYRIMIDINE] 11 OXO 18BETA OLEAN 12 EN 30 IC ACID; 3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL 2 4 AMINOBENZOYLSULFAMIDO 4,6 DIMETHYLPYRIMIDINE)N BETA DEXTRO GLUCURONOPYRANOSYL 2 4 AMINOBENZOYLSULFAMIDO 4,6 DIMETHYLPYRIMIDINE] 11 OXO 18BETA OLEAN 12 EN 30 IC ACID; 3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL 2 AMINOPYRIDINE)N BETA DEXTRO GLUCURONOPYRANOSYL 2 AMINOPYRIDINE] 11,30 DIOXO 18BETA OLEAN 12 EN 30 (N 2 AMINOPYRIDINE); 3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL 4 AMINODIPHENYL)N BETA DEXTRO GLUCURONOPYRANOSYL 4 AMINODIPHENYL] 11 OXO 18BETA OLEAN 12 EN 30 IC ACID; 3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL 5 AMINOURACIL)N BETA DEXTRO GLUCURONOPYRANOSYL 5 AMINOURACIL] 11 OXO 18BETA OLEAN 12 EN 30 IC ACID; 3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL 6 4 AMINOBENZOYLSULFAMIDO 3 METHYOXYPYRIDAZINE)N BETA DEXTRO GLUCURONOPYRANOSYL 6 4 AMINOBENZOYLSULFAMIDO 3 METHYOXYPYRIDAZINE] 11 OXO 18BETA OLEAN 12 EN 30 IC ACID; 3BETA O[2 O(N BETA DEXTRO GLUCURONOPYRANOSYL HISTIDINE METHYL ESTER)N BETA DEXTRO GLUCURONOPYRANOSYL HISTIDINE METHYL ESTER] 11 OXO 18BETA OLEAN 12 EN 30 IC ACID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DICYCLOHEXYLCARBODIIMIDE; GLYCYRRHIZIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GLYCYRRHIZA; HUMAN; HUMAN CELL; METHYLATION; SUBSTITUTION REACTION;

EID: 70549083812     PISSN: 0091150X     EISSN: 15739031     Source Type: Journal    
DOI: 10.1007/s11094-009-0316-x     Document Type: Article

References (18)

1. GA Tolstikov LA Baltina EE Shul'ts AG Pokrovskii 1997 Bioorgan. Khimiya 23 691 709 1:CAS:528:DyaK1cXisV0%3D
2. AJ Vlietinck T De Bruyne S Apers LA Pieters 1998 Planta Med. 64 97 109 10.1055/s-2006-957384 1:CAS:528:DyaK1cXhsVOmtLc%3D 9525100
3. E De Clerq 1995 J. Med. Chem. 38 2491 2517 10.1021/jm00014a001
4. E De Clerq 2000 Med. Res. Rev. 20 323 349 10.1002/1098-1128(200009)20: 5<323::AID-MED1>3.0.CO;2-A
5. M Ito M Nakashima M Baba, et al. 1987 Antiviral Res. 7 127 137 10.1016/0166-3542(87)90001-5 1:CAS:528:DyaL2sXksFWnsbw%3D 3475037
6. M Ito 1989 Jikken Igaku 7 858 860 1:CAS:528:DyaL1MXksV2ksbc%3D
7. M Ito A Sato K Hirabayashi, et al. 1988 Antiviral Res. 10 289 298 10.1016/0166-3542(88)90047-2 1:CAS:528:DyaL1MXhvVGnsL8%3D 3250333
8. N Ikegami S Kinoshita T Kanesaki, et al. 1996 Antiviral Res. 30 A33 10.1016/0166-3542(96)80279-8
9. TS Tochikura H Nakashima N Yamamoto 1989 J. Acquired Immune Def. Syndrome 2 441 447 1:CAS:528:DyaL1MXmtVyktb0%3D
10. O. A. Plyasunova, I. N. Egoricheva, N. V. Fedyuk, et al., Vopr. Virusol., No. 5 - 6, 235 - 238 (1992).
11. O. A. Plyasunova, Master's Thesis in Biological Sciences [in Russian], Kol'tsovo (1992).
12. RM Kondratenko LA Baltina SR Mustafina, et al. 2004 Bioorgan. Khimiya 30 308 315 1:STN:280:DC%2BD2cvjvVGmtQ%3D%3D
13. LA Baltina 2003 Curr. Med. Chem. 10 155 171 1:CAS:528: DC%2BD3sXlt1Crtw%3D%3D 12570715
14. LA Baltina EV Vasil'eva VA Davydova, et al. 1996 Khim.-Farm. Zh. 30 8 14 16 1:CAS:528:DyaK28XlsFSqt78%3D
15. G. A. Tolstikov, L. M. Khalilov, L. A. Baltina, et al., Khim. Prirod. Soedin., No. 5, 645 - 654 (1985).
16. RM Kondratenko LA Baltina SR Mustafina, et al. 2001 Khim.-Farm. Zh. 35 2 39 42
17. M. D. Mashkovskii, Therapeutic Substances, in 2 Volumes [in Russian], OOO Novaya Volna, Moscow, Vol. 2 (2000).
18. LA Baltina RM Kondratenko SR Mustafina, et al. 2001 Khim.-Farm. Zh. 35 1 38 41