Mechanism of ethanol-induced insulin secretion from INS-1 and INS-1E tumor cell lines

Cellular Physiology and Biochemistry

Volumn 24, Issue 5-6, 2009, Pages 441-450

  Hafko, Roman ^a   Orená, Martina ^a   Baová, Zuzana ^a,b   Kolláriková, Gabriela ^c   Lacík, Igor ^c   Strbák, Vladimír ^a,b  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^c POLYMER INSTITUTE   (Slovakia)

Author keywords

Ethanol; Insulin secretion; PKC; PTP; SNARE

Indexed keywords

ALCOHOL; BISINDOLYLMALEIMIDE; CALCIUM; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUCOSE; INSULIN; N ETHYLMALEIMIDE; PROTEIN KINASE C; PROTEIN TYROSINE PHOSPHATASE; SNARE PROTEIN; TETANUS TOXIN; ZINC CHLORIDE;

ANIMAL CELL; ARTICLE; CALCIUM DEPLETION; CANCER CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CULTURE MEDIUM; EXOCYTOSIS; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 70450278915     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000257482     Document Type: Article

References (70)

1. Lange J, Arends J, Willms B: Alcohol-induced hypoglycemia in type I diabetic patients. Med Klin (Munich) 1991;86:551-554.
2. Flanagan D, Wood P, Sherwin R, Debrah K, Kerr D: Gin and tonic and reactive hypoglycemia: what is important-the gin, the tonic, or both? J Clin Endocrinol Metab 1998;83:796-800.
3. Huang Z, Sjoholm A: Ethanol acutely stimulates islet blood flow, amplifies insulin secretion, and induces hypoglycemia via nitric oxide and vagally mediated mechanisms. Endocrinology 2008;149:232-236.
4. Benický J, Nikodémová M, Scsuková S, Zórad S, Strbák V: Four-week ethanol drinking increases both thyrotropin-releasing hormone (TRH) release and content in rat pancreatic islets. Life Sci 2000;66:629-639.
5. Straub SG, Sharp GW: Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 2002;18:451-463.
6. Blackard WG, Kikuchi M, Rabinovitch A, Renold AE: An effect of hyposmolarity on insulin release in vitro. Am J Physiol 1975;228:706-713.
7. Bacová Z, Benický J, Lukyanetz EE, Lukyanets IA, Štrbák V: Different signaling pathways involved in glucose and cell swelling-induced insulin secretion by rat pancreatic islets in vitro. Cell Physiol Biochem 2005;16:59-68.
8. Bacová Z, Orecná M, Hafko R, Štrbák V: Cell swelling-induced signaling for insulin secretion bypasses steps involving G proteins and PLA2 and is N-ethylmaleimide insensitive. Cell Physiol Biochem 2007;20:387-396.
9. Orecná M, Hafko R, Bacová Z, Podskocová J, Chorvát D Jr, Štrbák V: Different secretory response of pancreatic islets and insulin secreting cell lines INS-1 and INS-1E to osmotic stimuli. Physiol Res 2008;57:935-945.
10. Shannan DB: Swelling-induced taurine transport: relationship with chloride channels, anion-exchangers and other swelling-activated transport pathways. Cell Physiol Biochem 2008;21:15-28.
11. Straub SG, Daniel S, Sharp GW: Hyposmotic shock stimulates insulin secretion by two distinct mechanisms. Studies with the betaHC9 cell. Am J Physiol Endocrinol Metab 2002;282:E1070-1076.
12. Wong SME, Chase HS Jr: Role of intracellular calcium in cellular volume regulation. Am J Physiol 1986;250:C481-852.
13. Sato N, Wang X, Greer MA, Greer SE, McAdams S: Evidence that ethanol induces prolactin secretion in GH4C1 cells by producing cell swelling with resultant calcium influx. Endocrinology 1990;127:3079-3086.
14. Sato N, Wang X, Greer MA, Greer SE, McAdams S: The permeant molecule urea stimulates prolactin secretion in GH4C1 cells by inducing Ca2+ influx through dihydropyridine-sensitive Ca2+ channels. Mol Cell Endocrinol 1990;70:273-279.
15. Sato N, Wang X, Greer MA: Hormone secretion stimulated by ethanol-induced cell swelling in normal rat adeno-hypophysial cells. Am J Physiol 1991;260:946-950.
16. Inukai T, Wang X, Greer MA, Greer SE: Isotonic but not hypertonic ethanol stimulates LHRH secretion from perifused rat median eminence. Neuroendo-crinology 1993;58:258-262.
17. Inukai T, Wang X, Greer SE, Greer MA: Cell swelling induced by medium hyposmolarity or isosmolar urea stimulates gonadotropin-releasing hormone secretion from perifused rat median eminence. Brain Res 1992;599:161-164.
18. Benický J, Greer MA, Štrbák V: Hyposmolar medium and ethanol in isosmotic solution induce the release of thyrotropin-releasing hormone (TRH) by isolated rat pancreatic islets. Life Sci 1997;60:865-872.
19. Kucerová J, Štrbák V: The osmotic component of ethanol and urea action is critical for their immediate stimulation of thyrotropin-releasing hormone (TRH) release from rat brain septum. Physiol Res 2001;50:309-314.
20. Hafko R, Orecná M, Bacová Z, Kirchnerova J, Chorvát D Jr, Štrbák V: Ethanol and urea affect insulin secretion from islets and insulinoma cells by different mechanisms. Biologia, sect. Cell Mol Biol 2009;64:1039-1045.
21. Best L, Brown PD, Yates AP, Perret J, Virreira M, Beauwens R, Malaisse WJ, Sener A, Delporte C: Contrasting effects of glycerol and urea transport on rat pancreatic beta-cell function. Cell Physiol Biochem 2009;23:255-264.
22. Greer MA, Greer SE, Opsahl Z, Maruta S: Comparison of hyposmolar and hyperosmolar effects on in vitro luteinizing hormone secretion by anterior pituitary cells. Proc Soc Exp Biol Med 1985;178:2-28
23. Štrbák V, Greer MA: Regulation of hormone secretion by acute cell volume changes. Ca(2+)-independent hormone secretion. Cell Physiol Biochem 2000;10:393-402.
24. Jakab M, Lach S, Bacová Z, Langelüddecke C, Strbák V, Schmidt S, Iglseder E, Paulmichl M, Geibel J, Ritter M: Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl-currents. Cell Physiol Biochem 2008;22(5-6):567-578.
25. Jahn R, Sudhof T: Membrane fusion and exocytosis. Annu Rev Biochem 1999;68:863-911.
26. Weber T, Zemelman BV, McNew JA, Westermann B, Gmachl M, Parlati F, Sollner TH, Rothman JE: SNAREpins: minimal machinery for membrane fusion. Cell 1998;92:759-772.
27. Wheeler MB, Sheu L, Ghai M, Bouquillon A, Grondin G, Weller U, Beaudoin AR, Bennett MK, Trimble WS, Gaisano HY: Characterization of SNARE protein expression in beta cell lines and pancreatic islets. Endocrinology 1996;137:1340-1348.
28. Ammala C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjoholm A, Rorsman P: Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells. Proc Natl Acad Sci U S A 1994;91:4343-4347.
29. Mendez CF, Leibiger IB, Leibiger B, Hoy M, Gromada J, Berggren PO, Bertorello AM: Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis. J Biol Chem 2003;278:44753-44757.
30. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 1995;9:484-496.
31. Newton AC: Regulation of protein kinase C. Curr Opin Cell Biol 1997;9:161-167.
32. Mellor H, Parker PJ: The extended protein kinase C superfamily. Biochem J 1998;332:281-292.
33. Hughes SJ, Christie MR, Ashcroft SJH: Potentiators of insulin secretion modulate Ca2+ sensitivity in rat pancreatic islets. Mol Cell Endocrinol 1987;50:231-236.
34. Hughes SJ, Ashcroft SJH: Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets. Biochem J 1988;249:825-830.
35. Jones PM, Salmon DMW, Howell SL: Protein phosphorylation in electrically permeabilized islets of Langerhans. Effects of Ca2+, cyclic AMP, a phorbol ester and noradrenaline. Biochem J 1988;254:397-403.
36. Nakamura J, Suda T, Ogawa Y, Takeo T, Suga S, Wakui M: Protein kinase C-dependent and-independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells. Cell Signal 2001;13:199-205.
37. Jakab M, Furst J, Gschwentner M, Botta G, Garavaglia ML, Bazzini C, Rodighiero S, Meyer G, Eichmueller S, Woll E, Chwatal S, Ritter M, Paulmichl M: Mechanisms sensing and modulating signals arising from cell swelling. Cell Physiol Biochem 2002;12:235-258.
38. Gong W, Xu H, Shimizu T, Morishima S, Tanabe S, Tachibe T, Uchida S, Sasaki S, Okada Y: ClC-3-independent, PKCde-pendent activity of volume-sensitive Cl channel in mouse ventricular cardio-myocytes. Cell Physiol Biochem 2004;14:213-224.
39. Tian YM, Urquidi V, Ashcroft SJ: Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion. Mol Cell Endocrinol 1996;119:185-193.
40. Zarelli VEP, Ruete MC, Roggero CM, Mayorga LS, Tomes CN: PTP1B dephosphorylates NSF and elicits SNARE complex dissasembly during human sperm exocytosis. J Biol Chem 2009; 284:10491-10503.
41. Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P: Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology 2004;145(2):667-678.
42. Zórad S, Svabová E, Klime I, Macho L: Comparison of radiochemical purity and tissue binding of labeled insulin prepared by lactoperoxidase and chloramine T iodination. Endocrinologia Experime-ntalis 1985;19:267-275.
43. Ashcroft FM, Rorsman P: Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989;54:87-143.
44. Misler S, Barnett DW, Gillis KD, Pressel DM: Electrophysiology of stimulus-secretion coupling in human beta-cells. Diabetes 1992;41:1221-1228.
45. Gilon P, Henquin JC: Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell. J Biol Chem 1992;267:20713-20720.
46. Vallar L, Biden TJ, Wollheim CB: Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. J Biol Chem. 1987;262:5049-5056.
47. Proks P, Eliasson L, Ammälä C, Rorsman P, Ashcroft FM: Ca(2+)-and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps. J Physiol 1996;496:255-264.
48. Daniell LC, Harris RA: Ethanol and inositol 1,4,5-trisphosphate release calcium from separate stores of brain microsomes. J Pharmacol Exp Ther 1989;250:875-881.
49. Mironov SL, Hermann A: Ethanol actions on the mechanisms of Ca2+mobilization in rat hippocampal cells are mediated by protein kinase C. Brain Res 1996;714:27-37.
50. Xiao ZM, Li LJ, Yu SZ, Lu ZN, Li C Y, Zheng JQ: Effects of extracelullar Ca2+ influx and intracellular Ca2+ release on ethanol-induced cytoplasmic Ca2+ overload in cultured superior cervical ganglion neurons. Neurosci Lett 2005;390:98-103.
51. Nikodémová M, Weismann P, Filipèík P, Mráz P, Greer MA, Štrbák V: Both iso-and hypertonic ethanol stimulate release of hypothalamic thyrotropin-releasing hormone despite opposite effect on neuron volume. Neuroscience 1997;80:1263-1269.
52. Shah J, Pant HC: Spontaneous calcium release induced by ethanol in the isolated rat brain microsomes. Brain Res 1988;474:94-99.
53. Grant AJ, Koski G, Treisman SN: Effect of chronic ethanol on calcium current and calcium uptake in undifferentiated PC12 cells. Brain Res 1993;6:280-284.
54. Wang X, Dayanithi G, Lemos JR, Nordman JJ, Treistman SN: Ethanol reduces vasopresin release by inhibiting calcium currents in nerve terminals. Brain Res 1991;551:338-341.
55. Qi M, Strand BL, Mørch Y, Lacík I, Wang Y, Salehi P, Barbaro B, Gangemi A, Kuechle J, Romagnoli T, Hansen MA, Rodriguez LA, Benedetti E, Hunkeler D, Skjåk-Braek G, Oberholzer J: Encapsulation of human islets in novel inhomogeneous alginate-ca2+/ba2+ microbeads: in vitro and in vivo function. Artif Cells Blood Substit Immobil Biotechnol 2008;36(5):403-420.
56. Cheng SY, Constantinidis I, Sambanis A: Insulin secretion dynamics of free and alginate-encapsulated insulinoma cells. Cytotechnology 2006;51:159-170.
57. Boudreault F, Grygorczyk R: Cell swelling-induced ATP release is tightly dependent on intracellular calcium elevations. J Physiol 2004;561:499-513.
58. Schiavo G, Poulain B, Rossetto O, Benfenati F, Tauc L, Montecucco C: Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc. EMBO J 1992;11:3577-3583.
59. Hausinger A, Volknandt W, Zimmermann. H Calcium-dependent endogenous proteolysis of the vesicle proteins synaptobrevin and synaptotagmin Neuroreport 1995 6 637-641
60. Kiraly-Borri CE, Morgan A, Burgoyne RD, Weller U, Wollheim CB, Lang J: Soluble N-ethylmaleimide-sensitive factor attachment protein and Nethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin. Biochem J 1996;314:199-203.
61. Littleton JT, Barnard RJ, Titus SA, Slind J, Chapman ER, Ganetzky B: SNARE complex disassembly by NSF follows synaptic-vesicle fusion. Proc Natl Acad Sci USA 2001;98:12233-12238.
62. Lonart G, Südhof TC: Assembly of SNARE core complexes prior to neurotransmitter release sets the readily releasable pool of synaptic vesicles. J Biol Chem 2000;275(36):27703-27707.
63. Eliasson L, Renstrom E, Ding WG, Proks P, Rorsman P: Rapid ATP-dependent priming of secretory granules precedes Ca2+-induced exocytosis in mouse pancreatic B-cells. J Physiol 1997;503:399-412.
64. Lauf PK, Adragna NC: Twenty-five years of K-Cl cotransport: from stimulation by a thiol reaction to cloning of the full length KCCs. Cell Volume and Signaling, Lauf PK, Adragna NC (eds), Advances in Experimental Medicine and Biology, Springer Science + Business Media, New York, 2005, vol 559, pp 11-28.
65. Lauf PK, Adragna NC: Temperature-induced functional deocclusion of thiols inhibitory for sheep erythrocyte K-Cl cotransport. Am J Physiol 1995;269:C1167-1175.
66. Aspinwall CA, Brooks SA, Kennedy RT, Lakey JR: Effects of intravesicular H+ and extracellular H+ and Zn2+ on insulin secretion in pancreatic beta cells. J Biol Chem 1997;272:31308-31314.
67. Orci L, Ravazzola M, Amherdt M, Madsen O, Perrelet A, Vassalli JD, Anderson RG: Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J Cell Biol 1986;103:2273-2281.
68. Hutton JC: The internal pH and membrane potential of the insulin-secretory granule. Biochem J 1982;204:171-178.
69. Brautigan DL, Bornstein P, Gallis B: Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn. J Biol Chem 1981;256:6519-6522.
70. Strbak V: Cell volume and Peptide hormone secretion. Contrib Nephrol 2006;152:210-220