Chronic proton pump inhibitor therapy associated with increased development of fundic gland polyps

Digestive Diseases and Sciences

Volumn 54, Issue 12, 2009, Pages 2617-2622

  Ally, Mazer R ^a,b   Veerappan, Ganesh R ^a   Maydonovitch, Corinne L ^a,b   Duncan, Timothy J ^a,b   Perry, Joseph L ^a,b   Osgard, Eric M ^a,b   Wong, Roy K H ^a,b  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Duration of the therapy; Fundic gland polyps; Prevalence; Proton pump inhibitor; Risk factors

Indexed keywords

PROTON PUMP INHIBITOR;

ADULT; ARTICLE; CAUCASIAN; CHRONIC DRUG ADMINISTRATION; DRUG DOSE COMPARISON; DRUG USE; ELECTIVE SURGERY; ENDOSCOPIC SURGERY; FEMALE; GASTROINTESTINAL SURGERY; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; STOMACH FUNDUS; STOMACH POLYP; TREATMENT DURATION;

ADULT; AGED; DISTRICT OF COLUMBIA; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTRIC FUNDUS; GASTROSCOPY; HOSPITALS, MILITARY; HUMANS; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; POLYPS; PROTON PUMP INHIBITORS; QUESTIONNAIRES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; STOMACH DISEASES; TIME FACTORS;

EID: 70450247184     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-009-0993-z     Document Type: Article

References (36)

1. HJ Freeman 2008 Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis World J Gastroenterol 14 1318 1320 10.3748/wjg.14.1318 18322941
2. AS Raghunath C O'Morain RC McLoughlin 2005 Review article: the long-term use of proton-pump inhibitors Aliment Pharmacol Ther 22 Suppl 1 55 63 10.1111/j.1365-2036.2005.02611.x 1:CAS:528:DC%2BD2MXhtVemsL%2FI 16042660
3. RJ Laheij MC Sturkenboom RJ Hassing J Dieleman BH Stricker JB Jansen 2004 Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs JAMA 292 1955 1960 10.1001/jama.292.16.1955 1:CAS:528:DC%2BD2cXptVeksr0%3D 15507580 (Pubitemid 39411203)
4. YX Yang JD Lewis S Epstein DC Metz 2006 Long-term proton pump inhibitor therapy and risk of hip fracture JAMA 296 2947 2953 10.1001/jama.296.24.2947 1:CAS:528:DC%2BD2sXnvVGn 17190895 (Pubitemid 46021498)
5. S Dial K Alrasadi C Manoukian A Huang D Menzies 2004 Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies CMAJ 171 33 38 15238493
6. H Van Vlierberghe M De Vos G De Cock C Cuvelier A Elewaut 1997 Fundic gland polyps: three other case reports suggesting a possible association with acid suppressing therapy Acta Gastroenterol Belg 60 240 242 9396183
7. JR Graham 1992 Gastric polyposis: onset during long-term therapy with omeprazole Med J Aust 157 287 288 1:STN:280:DyaK3s%2Fmt1emtw%3D%3D 1435464
8. HM el-Zimaity FW Jackson DY Graham 1997 Fundic gland polyps developing during omeprazole therapy Am J Gastroenterol 92 1858 1860 1:STN:280: DyaK1c%2FisFOlsQ%3D%3D 9382052
9. U Choudhry HW Boyce Jr D Coppola 1998 Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics Am J Clin Pathol 110 615 621 1:STN:280:DyaK1M%2FhslegsA%3D%3D 9802346
10. M Jalving JJ Koornstra J Wesseling HM Boezen S de Jong JH Kleibeuker 2006 Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy Aliment Pharmacol Ther 24 1341 1348 10.1111/j.1365-2036.2006.03127.x 1:CAS:528:DC%2BD28Xhtlant7rJ 17059515 (Pubitemid 44571564)
11. RW Burt 2003 Gastric fundic gland polyps Gastroenterology 125 1462 1469 10.1016/j.gastro.2003.07.017 14598262 (Pubitemid 37409766)
12. SC Abraham B Nobukawa FM Giardiello SR Hamilton TT Wu 2000 Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations Am J Pathol 157 747 754 1:CAS:528:DC%2BD3cXmvFWqtrc%3D 10980114
13. SW Carmack RM Genta CM Schuler MH Saboorian 2009 The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients Am J Gastroenterol 104 1524 1532 10.1038/ajg.2009.139 19491866
14. MA Marcial M Villafaña J Hernandez-Denton JR Colon-Pagan 1993 Fundic gland polyps: prevalence and clinicopathologic features Am J Gastroenterol 88 1711 1713 1:STN:280:DyaK2c%2Fis12nsw%3D%3D 8213712
15. M Torbenson JH Lee M Cruz-Correa W Ravich K Rastgar SC Abraham TT Wu 2002 Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis Mod Pathol 15 718 723 10.1097/01.MP.0000018976.15044.9B 12118109 (Pubitemid 34787307)
16. SC Abraham B Nobukawa FM Giardiello SR Hamilton TT Wu 2001 Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene Am J Pathol 158 1005 1010 1:CAS:528: DC%2BD3MXitlOnu7c%3D 11238048
17. P Domizio IC Talbot AD Spigelman CB Williams RK Phillips 1990 Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients J Clin Pathol 43 738 743 10.1136/jcp.43.9.738 1:STN:280:DyaK3M%2FgvF2itw%3D%3D 2170464
18. AJ Goodman SA Dundas JH Scholefield BF Johnson 1988 Gastric carcinoma and familial adenomatous polyposis (FAP) Int J Colorectal Dis 3 201 203 10.1007/BF01660713 1:STN:280:DyaL1M%2FmslKqtg%3D%3D 2848912 (Pubitemid 19000957)
19. M Jalving JJ Koornstra W Boersma-van Ek S de Jong A Karrenbeld H Hollema EG de Vries JH Kleibeuker 2003 Dysplasia in fundic gland polyps is associated with nuclear beta-catenin expression and relatively high cell turnover rates Scand J Gastroenterol 38 916 922 10.1080/00365520310005433 1:CAS:528: DC%2BD3sXmvF2hs70%3D 14531526 (Pubitemid 37153618)
20. M Stolte M Vieth MP Ebert 2003 High-grade dysplasia in sporadic fundic gland polyps: clinically relevant or not? Eur J Gastroenterol Hepatol 15 1153 1156 10.1097/00042737-200311000-00001 14560146 (Pubitemid 38174837)
21. M Vieth M Stolte 2001 Fundic gland polyps are not induced by proton pump inhibitor therapy Am J Clin Pathol 116 716 720 10.1309/XFWR-LXA7-7TK1-N3Q8 1:CAS:528:DC%2BD3MXosV2qs7k%3D 11710689 (Pubitemid 34453213)
22. R Fossmark CS Jianu TC Martinsen G Qvigstad U Syversen HL Waldum 2008 Serum gastrin and chromogranin a levels in patients with fundic gland polyps caused by long-term proton-pump inhibition Scand J Gastroenterol 43 20 24 10.1080/00365520701561959 1:CAS:528:DC%2BD1cXhtF2kuw%3D%3D 18938772
23. T Masaoka H Suzuki T Hibi 2008 Gastric epithelial cell modality and proton pump inhibitor J Clin Biochem Nutr 42 191 196 10.3164/jcbn.2008028 1:CAS:528:DC%2BD1cXotFaisrw%3D 18545640 (Pubitemid 351916672)
24. TJ Koh D Chen 2000 Gastrin as a growth factor in the gastrointestinal tract Regul Pept 93 37 44 10.1016/S0167-0115(00)00176-2 1:CAS:528: DC%2BD3cXntF2htbo%3D 11033051 (Pubitemid 30734347)
25. I Synnerstad L Holm 1997 Omeprazole induces high intraglandular pressure in the rat gastric mucosa Gastroenterology 112 1221 1230 10.1016/S0016-5085(97) 70134-3 1:CAS:528:DyaK2sXislyhtLg%3D 9098006 (Pubitemid 27157534)
26. A Cats BE Schenk E Bloemena R Roosedaal J Lindeman I Biemond EC Klinkenberg-Knol SG Meuwissen EJ Kuipers 2000 Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment Hum Pathol 31 684 690 10.1053/hupa.2000.7637 1:CAS:528:DC%2BD3cXksVGhtb4%3D 10872661
27. S Krishnamurthy Y Dayal 1997 Parietal cell protrusions in gastric ulcer disease Hum Pathol 28 1126 1130 10.1016/S0046-8177(97)90249-5 1:STN:280:DyaK1c%2FgtFCrsQ%3D%3D 9343318 (Pubitemid 27446597)
28. N Watanabe H Seno T Nakajima S Yazumi S Miyamoto S Matsumoto T Itoh C Kawanami K Okazaki T Chiba 2002 Regression of fundic gland polyps following acquisition of Helicobacter pylori Gut 51 742 745 10.1136/gut.51.5.742 1:STN:280:DC%2BD38nitVGltA%3D%3D 12377817 (Pubitemid 35216866)
29. M Iida T Yao H Watanabe K Imamura S Fuyuno T Omae 1980 Spontaneous disappearance of fundic gland polyposis: report of three cases Gastroenterology 79 725 728 1:STN:280:DyaL3M%2FgsV2ksQ%3D%3D 7409391
30. S Sekine T Shibata Y Yamauchi Y Nakanishi T Shimoda M Sakamoto S Hirohashi 2002 Beta-catenin mutations in sporadic fundic gland polyps Virchows Arch 440 381 386 10.1007/s004280100527 1:CAS:528:DC%2BD38Xks1GmsLc%3D 11956818 (Pubitemid 34328069)
31. WT Hofgärtner M Thorp MW Ramus G Delorefice WY Chey CK Ryan GW Takahashi JR Lobitz 1999 Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis Am J Gastroenterol 94 2275 2281 10445562
32. DY Graham RM Genta 2008 Long-term proton pump inhibitor use and gastrointestinal cancer Curr Gastroenterol Rep 10 543 547 10.1007/s11894-008- 0100-1 19006608
33. TM Attard JH Yardley C Cuffari 2002 Gastric polyps in pediatrics: an 18-year hospital-based analysis Am J Gastroenterol 97 298 301 10.1111/j.1572-0241.2002.05461.x 1:STN:280:DC%2BD387jtVOiug%3D%3D 11866265
34. A Zwick M Munir CK Ryan J Gian RW Burt M Leppert L Spirio WY Chey 1997 Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli Gastroenterology 113 659 663 10.1053/gast.1997.v113.pm9247488 1:STN:280:DyaK2szptVKgsw%3D%3D 9247488 (Pubitemid 27351795)
35. SC Abraham SJ Park L Mugartegui SR Hamilton TT Wu 2002 Sporadic fundic gland polyps with epithelial dysplasia: evidence for preferential targeting for mutations in the adenomatous polyposis coli gene Am J Pathol 161 1735 1742 1:CAS:528:DC%2BD38XptV2gtL0%3D 12414520
36. M Jalving JJ Koornstra JM Götz LA van der Waaij S de Jong N Zwart A Karrenbeld JH Kleibeuker 2003 High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature Eur J Gastroenterol Hepatol 15 1229 1233 10.1097/00042737-200311000-00013 14560158 (Pubitemid 38174849)