Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice

Molecular and Cellular Biochemistry

Volumn 332, Issue 1-2, 2009, Pages 215-224

  Kundu, Soumi ^a   Tyagi, Neetu ^a   Sen, Utpal ^a   Tyagi, Suresh C ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Cochlea; Homocysteine; Matrix metalloproteinase; Oxidative stress; Tissue inhibitors of metalloproteinase

Indexed keywords

COLLAGENASE 3; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; GELATINASE A; GELATINASE B; HOMOCYSTEINE; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; PROTEIN P22; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ARTICLE; COCHLEA; COCHLEA DUCT; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; HAIR CELL; HEARING LOSS; HETEROZYGOSITY; HYPERHOMOCYSTEINEMIA; MOUSE; NITROSATIVE STRESS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; COCHLEA; CYSTATHIONINE BETA-SYNTHASE; EXTRACELLULAR MATRIX; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASES;

MUS;

EID: 70450247104     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0194-2     Document Type: Article

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