Drugs for the treatment of African sleeping sickness: Developments in the last century;Im letzten jahrhundert entwickelt: Wirkstoffe zur behandlung der Afrikanischen schlafkrankheit

Pharmazie in Unserer Zeit

Volumn 38, Issue 6, 2009, Pages 552-558

  Schlitzer, Martin ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIMINAZENE; EFLORNITHINE; MELARSENOXIDE; MELARSOPROL; NIFURTIMOX; PENTAMIDINE; TRYPARSAMIDE; ANTITRYPANOSOMAL AGENT; SURAMIN;

AFRICAN TRYPANOSOMIASIS; DRUG STRUCTURE; HUMAN; MEDICAL RESEARCH; REVIEW; TRYPANOSOMA BRUCEI; TRYPANOSOMA GAMBIENSE; ANIMAL; HISTORY;

ANIMALS; EFLORNITHINE; HISTORY, 20TH CENTURY; HUMANS; MELARSOPROL; NIFURTIMOX; PENTAMIDINE; SURAMIN; TRYPANOCIDAL AGENTS; TRYPANOSOMIASIS, AFRICAN;

EID: 70450245349     PISSN: 00483664     EISSN: 16151003     Source Type: Journal    
DOI: 10.1002/pauz.200900344     Document Type: Review

References (10)

1. Barrett, M.P., Boykin, D.W., Brun, R., Tidwell, R.R.: Human African trypanosomiasis. pharmacological re-engagement with a neglected disease. Br. J. Pharmacol. 152 (2007), 1155-1171.
2. Delespaux, V., de Koning, H.P.: Drugs and drug resistance in African trypanosomiasis. Drug Resist. Updates 10 (2007), 30-50. (Pubitemid 46636383)
3. Lüscher, A., de Koning, H.P., Mäser, P.: Chemotherapeutic Strategies against Trypanosoma brucei: Drug Targets vs. Drug Targeting. Curr. Pharm. Des. 13 (2007), 555-567.
4. de Koning, H.P.: Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes. Trends Parasitol. 24 (2008), 345-349.
5. Werbovetz, V.: Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Curr. Opin. Investig. Drugs 7 (2006), 147-157.
6. Lanteri, C.A., Tidwell, R.R., Meshnick, S.R.: The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. Antimicrob. Agents Chemother. 52 (2008), 875-882.
7. Poulin, R., Lu, Li, Ackermann, B., Bey, P., and Pegg, A.E.: Mechanism of the Irreversible Inactivation of Mouse Ornithine Decarboxylase by α-Difluoromethylornithine. J. Biol. Chem. 267 (1992), 150-158.
8. Prathalingham, S.R., Wilkinson, S.R., Horn, D., Kelly J.M.: Delection of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox ans Benznidazole. Antimicrob. Agents Chemother. 51 (2007), 755-758.
9. Wilkinson, S.R., Taylor, M.C., Horn, D., Kelly, J.M., Cheeseman, I.: A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc. Natl. Acad. Sci. USA 105 (2008) 5022-5027.
10. Priotto, G., Fogg, C., Balasegaram, M., Erphas, O., Louga, A., Checchi, F., Ghabri, S., Piola, P.: Three Drug Combinations for Late-Stage - Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda. PLOS Clin. Trials(2006), Dec 8;1(8):e39.