The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

Oncogene

Volumn 28, Issue 46, 2009, Pages 4041-4052

  Chua, Y L ^a   Ito, Y ^b   Pole, J C M ^a,e   Newman, S ^a   Chin, S F ^b   Stein, R C ^c,f   Ellis, I O ^d   Caldas, C ^b   O'Hare, M J ^c,g   Murrell, A ^b   Edwards, P A W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e ILLUMINA INC   (United States)

^f UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Breast cancer; Chromosome rearrangement; DNA methylation; Heregulins; NRG1; Tumour suppressor gene

Indexed keywords

NEU DIFFERENTIATION FACTOR; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; NRG1 GENE; ONCOGENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 8; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NEUREGULIN-1; TRANSCRIPTION INITIATION SITE;

EID: 70450236961     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.259     Document Type: Article

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