Transcription Factor Nrf2 Plays a Pivotal Role in Protection Against Traumatic Brain Injury-Induced Acute Intestinal Mucosal Injury in Mice

Journal of Surgical Research

Volumn 157, Issue 2, 2009, Pages 251-260

  Jin, Wei ^a   Wang, Han Dong ^a   Hu, Zhi gang ^a   Yan, Wei ^b   Chen, Gang ^a   Yin, Hong Xia ^a  

^a JINLING HOSPITAL   (China)

^b Second Affiliated Hospital   (China)

Author keywords

inflammation; intestine; nuclear factor E2 related factor 2; oxidative stress; traumatic brain injury

Indexed keywords

CYTOKINE; ENDOTOXIN; GLUTATHIONE TRANSFERASE A1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; GENE EXPRESSION; INFLAMMATION; INTESTINE CRYPT; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRAUMATIC BRAIN INJURY; WILD TYPE;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CELL MEMBRANE PERMEABILITY; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTOXINS; FEMALE; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTESTINAL MUCOSA; JEJUNUM; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MICROVILLI; NF-E2-RELATED FACTOR 2; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70450235482     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.08.003     Document Type: Article

References (35)

1. Pilitsis J.G., and Rengachary S.S. Complications of head injury. Neurol Res 23 (2001) 227
2. Hang C.H., Shi J.X., Li J.S., et al. Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats. World J Gastroenterol 9 (2003) 2776
3. Doig C.J., Sutherland L.R., Sandham J.D., et al. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 158 (1998) 444
4. Hang C.H., Shi J.X., Li J.S., et al. Expressions of intestinal NF-κB, TNF-α, and IL-6 following traumatic brain injury in rats. J Surg Res 123 (2005) 188
5. Shohami E., Gati I., Beit-Yannai E., et al. Closed head injury in the rat induces whole body oxidative stress: Overall reducing antioxidant profile. J Neurotrauma 16 (1999) 365
6. Chen X.L., and Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: A new therapeutic approach for the treatment of inflammatory diseases. Curr Pham Des 10 (2004) 879
7. Owuor E.D., and Kong A.N. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 64 (2002) 765
8. Lee J.M., and Johnson J.A. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 37 (2004) 139
9. Itoh K., Chiba T., Takahashi S., et al. An Nrf2/small Maf heterodimer mediates the induction of Phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236 (1997) 313
10. Osburn W.O., Wakabayashi N., Misra V., et al. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys 454 (2006) 7
11. Jain A.K., Bloom D.A., and Jaiswal A.K. Nuclear import and export signals in control of Nrf2. J Biol Chem 280 (2005) 29158
12. Lee J.M., Li J., Johnson D.A., et al. Nrf2, a multiorgan protector?. FASEB J 19 (2005) 1061
13. McMahon M., Itoh K., Yamamoto M., et al. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 61 (2001) 3299
14. Ramos-Gomez M., Kwak M.K., Dolan P.M., et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98 (2001) 2941
15. Khor T.O., Huang M.T., Kwon K.H., et al. Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 66 (2006) 11580
16. Osburn W.O., Karim B., Dolan P.M., et al. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer 121 (2007) 1883
17. Chung F.L., Conaway C.C., Rao C.V., et al. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21 (2000) 2287
18. Hall E.D. High-dose glucocorticoid treatment improves neurological recovery in head-injured mice. J Neurosurg 62 (1985) 882
19. Kupina N.C., Nath R., Bernath E.E., et al. The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury. J Neurotrauma 18 (2001) 1229
20. Chen G., Shi J.X., Qi M., et al. Effects of progesterone on intestinal inflammatory response, mucosa structure alterations and apoptosis following traumatic brain injury in male rats. J Surg Res 147 (2008) 92
21. Benson A.M., Hunkeler M.J., and Talalay P. Increase of NAD(P)H: Quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity. Proc Natl Acad USA 77 (1980) 5216
22. Kelly V.P., Ellis E.M., Manson M.M., et al. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer Res 60 (2000) 957
23. Hang C.H., Shi J.X., Sun B.W., et al. Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury. J Surg Res 137 (2007) 53
24. Rangasamy T., Cho C.Y., Thimmulappa R.K., et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 114 (2004) 1248
25. Rangasamy T., Guo J., Mitzner W.A., et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 202 (2005) 47
26. Braun S., Hanselmann C., Gassmann M.G., et al. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol Cell Biol 22 (2002) 5492
27. Thimmulappa R.K., Lee H., Rangasamy T., et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 116 (2006) 984
28. Sasaki M., and Joh T. Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant protective agents. J Clin Biochem Nutr 40 (2007) 1
29. Soffler C. Oxidative stress. Vet Clin North Am Equine Pract 23 (2007) 135
30. Ross D., Siegel D., Beall H., et al. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. Cancer Metastasis Rev 12 (1993) 83
31. Hecht S.S. Chemoprevention by isothiocyanates. J Cell Biochem 22 Suppl (1995) 195
32. Sugie S., Okamoto K., Okumura A., et al. Inhibitory effects of benzyl thiocyanate and benzyl isothiocyanate on methylazoxymethanol acetate-induced intestinal carcinogenesis in rats. Carcinogenesis 15 (1994) 1555
33. Shapiro T.A., Fahey J.W., Wade K.L., et al. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev 10 (2001) 501
34. Begleiter A., Sivananthan K., Curphey T.J., et al. Induction of NAD(P)H quinone:oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats. Cancer Epidemiol Biomarkers Prev 12 (2003) 566
35. Pool-Zobel B., Veeriah S., and Böhmer F.D. Modulation of xenobiotic metabolizing enzymes by anticarcinogens-focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. Mutat Res 591 (2005) 74