A hypothesis and model of reduced fetal movement as a common pathogenetic mechanism in clubfoot

Medical Hypotheses

Volumn 73, Issue 6, 2009, Pages 986-988

  Hester, T W ^a   Parkinson, L C ^a   Robson, J ^a   Misra, S ^a   Sangha, H ^a   Martin, J E ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BONE DEVELOPMENT; CLUBFOOT; CONGENITAL DISORDER; DEVELOPMENTAL DISORDER; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; FETUS MOVEMENT; FOOT MALFORMATION; GENETIC PREDISPOSITION; HUMAN; MORPHOGENESIS; NEUROMUSCULAR DISEASE; NONHUMAN; OLIGOHYDRAMNIOS; PATHOGENESIS; PES EQUINOVARUS; PRIORITY JOURNAL;

CLUBFOOT; FETAL MOVEMENT; HUMANS; MODELS, THEORETICAL;

EID: 70450227513     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.04.056     Document Type: Article

References (36)

1. Miedzybrodzka Z. Congenital Talipes equinovarus (clubfoot): a disorder of the foot but not the hand. J Anat 202 1 (2003) 37-42
2. Blakeslee T.J. Congenital idiopathic Talipes equinovarus (clubfoot). Current concepts. Clin Podiatr Med Surg 14 1 (1997) 9-56
3. Chapman C., Stott N.S., Port R.V., et al. Genetics of club foot in Maori and Pacific people. J Med Genet 37 9 (2000) 680-683
4. Dietz F. The genetics of idiopathic clubfoot. Clin Orthop Relat Res 401 (2002) 39-48
5. Dietz F.R. On the pathogenesis of clubfoot. Lancet 1 8425 (1985) 388-390
6. Porter R.W. Clubfoot: congenital Talipes equinovarus. J R Coll Surg Edinb 40 1 (1995) 66-71
7. Wynne-Davies R. Genetic and environmental factors in the etiology of Talipes equinovarus. Clin Orthop Relat Res 84 (1972) 9-13
8. Czeizel A., Bellyei A., Kranicz J., et al. Confirmation of the multifactorial threshold model for congenital structural Talipes equinovarus. J Med Genet 18 2 (1981) 99-100
9. Yang H.Y., Chung C.S., and Nemechek R.W. A genetic analysis of clubfoot in Hawaii. Genet Epidemiol 4 4 (1987) 299-306
10. Wang J.H., Palmer R.M., and Chung C.S. The role of major gene in clubfoot. Am J Hum Genet 42 5 (1988) 772-776
11. Dunn P.M. Congenital postural deformities: perinatal associations. Proc R Soc Med 65 8 (1972) 735-738
12. Dunn P.M. Pathogenesis of clubfoot. Lancet 1 8429 (1985) 635-636
13. Farrell S.A., Summers A.M., Dallaire L., et al. Club foot, an adverse outcome of early amniocentesis: disruption or deformation? CEMAT, Canadian Early and Mid-Trimester Amniocentesis Trial. J Med Genet 36 11 (1999) 843-846
14. DeMyer W., and Baird I. Mortality and skeletal malformations from amniocentesis and oligohydramnios in rats: cleft palate, clubfoot, microstomia, and adactyly. Teratology 2 1 (1969) 33-37
15. Randomised trial to assess safety and fetal outcome of early and midtrimester amniocentesis. The Canadian Early and Mid-trimester Amniocentesis Trial (CEMAT) Group. Lancet 1998;351(9098):242-7.
16. Bohm M. The embryologic origin of clubfoot. J Bone Joint Surg 11 1 (1929) 229-259
17. Delgado-Baeza E., Santos-Alvarez I., and Martos-Rodriguez A. Retinoic acid-induced clubfoot-like deformity: pathoanatomy in rat fetuses. J Pediatr Orthop B 8 1 (1999) 12-18
18. Victoria-Diaz A., and Victoria-Diaz J. Pathogenesis of idiopathic clubfoot. Clin Orthop Relat Res 185 (1984) 14-24
19. Bechtol C.O., and Mossman H.W. Clubfoot; an embryological study of associated muscle abnormalities. J Bone Joint Surg Am 32 A:4 (1950) 827-838
20. Windisch G., Anderhuber F., Haldi-Brandle V., et al. Additional muscle in idiopathic club foot. Eur J Pediatr Surg 16 4 (2006) 294-296
21. Kaplan E.B. Comparative anatomy of the talus in relation to idiopathic clubfoot. Clin Orthop Relat Res 85 (1972) 32-37
22. Atlas S., Menacho L.C., and Ures S. Some new aspects in the pathology of clubfoot. Clin Orthop Relat Res 149 (1980) 224-228
23. Hootnick D.R., Packard Jr. D.S., Levinsohn E.M., et al. Confirmation of arterial deficiencies in a limb with necrosis following clubfoot surgery. J Pediatr Orthop B 8 3 (1999) 187-193
24. Feldbrin Z., Gilai A.N., Ezra E., et al. Muscle imbalance in the aetiology of idiopathic club foot. An electromyographic study. J Bone Joint Surg Br 77 4 (1995) 596-601
25. Irani R.N., and Sherman M.S. The pathological anatomy of idiopathic clubfoot. Clin Orthop Relat Res 84 (1972) 14-20
26. Shoro A.A. Intra-uterine growth retardation and limb deformities produced by neuromuscular blocking agents in the rat fetus. J Anat 123 Pt 2 (1977) 341-350
27. Persson M. The role of movements in the development of sutural and diarthrodial joints tested by long-term paralysis of chick embryos. J Anat 137 Pt 3 (1983) 591-599
28. Gosztonyi G., Dorfmuller-Kuchlin S., Sparmann M., et al. Morphometric study of muscle in congenital idiopathic club foot. Pathol Res Pract 185 5 (1989) 790-794
29. Herceg M.B., Weiner D.S., Agamanolis D.P., et al. Histologic and histochemical analysis of muscle specimens in idiopathic Talipes equinovarus. J Pediatr Orthop 26 1 (2006) 91-93
30. Dobbs M.B., Walton T., Gordon J.E., et al. Flexor digitorum accessorius longus muscle is associated with familial idiopathic clubfoot. J Pediatr Orthop 25 3 (2005) 357-359
31. Archer C.W., Dowthwaite G.P., and Francis-West P. Development of synovial joints. Birth Defects Res C: Embryo Today 69 2 (2003) 144-155
32. Bastow E.R., Lamb K.J., Lewthwaite J.C., et al. Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formation. J Biol Chem 280 12 (2005) 11749-11758
33. Dowthwaite G.P., Flannery C.R., Flannelly J., et al. A mechanism underlying the movement requirement for synovial joint cavitation. Matrix Biol 22 4 (2003) 311-322
34. Lewthwaite J.C., Bastow E.R., Lamb K.J., et al. A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. J Biol Chem 281 16 (2006) 11011-11018
35. Maffulli N., Capasso G., Testa V., et al. Histochemistry of the triceps surae muscle in idiopathic congenital clubfoot. Foot Ankle 13 2 (1992) 80-84
36. Kim S.R., Won H.S., Lee P.R., et al. Four-dimensional ultrasound guidance of prenatal invasive procedures. Ultrasound Obst Gyn 26 6 (2005) 663-665