Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies

Molecular Immunology

Volumn 47, Issue 2-3, 2009, Pages 457-464

  Acchione, Mauro ^a   Lipschultz, Claudia A ^a   DeSantis, Morgan E ^a   Shanmuganathan, Aranganathan ^a   Li, Mi ^a,b   Wlodawer, Alexander ^a   Tarasov, Sergey ^c   Smith Gill, Sandra J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c Structural Biophysics Laboratory   (United States)

Author keywords

Affinity maturation; CDR; Enthalpy; Flexibility; Glycine; Van't Hoff; Water; X ray crystallography

Indexed keywords

ENZYME ANTIBODY; HYHEL 10 ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; LYSOZYME; UNCLASSIFIED DRUG; WATER;

ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CHIMERA; CONTROLLED STUDY; ENTHALPY; ENZYME BINDING; HYDROPHOBICITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SOMATIC MUTATION; THERMODYNAMICS;

ANTIBODIES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; GLYCINE; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MODELS, MOLECULAR; MURAMIDASE; MUTATION; PLIABILITY; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; WATER;

EID: 70450224882     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.08.018     Document Type: Article

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