-
1
-
-
59649115254
-
Neuroscience: glia-more than just brain glue
-
Allen N.J., and Barres B.A. Neuroscience: glia-more than just brain glue. Nature 457 (2009) 675-677
-
(2009)
Nature
, vol.457
, pp. 675-677
-
-
Allen, N.J.1
Barres, B.A.2
-
2
-
-
0024234381
-
Nervenkitt: notes on the history of the concept of neuroglia
-
Somjen G.G. Nervenkitt: notes on the history of the concept of neuroglia. GLIA 1 (1988) 2-9
-
(1988)
GLIA
, vol.1
, pp. 2-9
-
-
Somjen, G.G.1
-
3
-
-
55049084760
-
The mystery and magic of glia: a perspective on their roles in health and disease
-
Barres B.A. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 60 (2008) 430-440
-
(2008)
Neuron
, vol.60
, pp. 430-440
-
-
Barres, B.A.1
-
4
-
-
32344450582
-
Sculpting the nervous system: glial control of neuronal development
-
Freeman M.R. Sculpting the nervous system: glial control of neuronal development. Curr Opin Neurobiol 16 (2006) 119-125
-
(2006)
Curr Opin Neurobiol
, vol.16
, pp. 119-125
-
-
Freeman, M.R.1
-
5
-
-
84901137121
-
Glia as active paricipants in the development and function of synapses
-
Edited by Hell J.W., and Ehlers M.D. (Eds), Springer
-
Eroglu C., Barres B.A., and Stevens B. Glia as active paricipants in the development and function of synapses. In: Edited by Hell J.W., and Ehlers M.D. (Eds). Structural and Functional Organization of the Synapse (2008), Springer 683-714
-
(2008)
Structural and Functional Organization of the Synapse
, pp. 683-714
-
-
Eroglu, C.1
Barres, B.A.2
Stevens B3
-
6
-
-
58149334892
-
Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity
-
Fellin T. Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity. J Neurochem 108 (2009) 533-544
-
(2009)
J Neurochem
, vol.108
, pp. 533-544
-
-
Fellin T1
-
7
-
-
0034636493
-
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
-
Bergles D.E., Roberts J.D., Somogyi P., and Jahr C.E. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405 (2000) 187-191
-
(2000)
Nature
, vol.405
, pp. 187-191
-
-
Bergles, D.E.1
Roberts, J.D.2
Somogyi, P.3
Jahr, C.E.4
-
9
-
-
67650966680
-
Microglial physiology: unique stimuli, specialized responses
-
Ransohoff R.M., Perry V.H., Ransohoff R.M., and Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 27 (2009) 119-145
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 119-145
-
-
Ransohoff, R.M.1
Perry, V.H.2
Ransohoff, R.M.3
Perry, V.H.4
-
10
-
-
68049143450
-
Tripartite synapses: astrocytes process and control synaptic information
-
Perea G., Navarrete M., and Araque A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci 32 (2009) 421-431
-
(2009)
Trends Neurosci
, vol.32
, pp. 421-431
-
-
Perea, G.1
Navarrete, M.2
Araque A3
-
11
-
-
0036139877
-
Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
-
Bushong E.A., Martone M.E., Jones Y.Z., and Ellisman M.H. Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci 22 (2002) 183-192
-
(2002)
J Neurosci
, vol.22
, pp. 183-192
-
-
Bushong, E.A.1
Martone, M.E.2
Jones, Y.Z.3
Ellisman, M.H.4
-
12
-
-
34250317399
-
Synaptic islands defined by the territory of a single astrocyte
-
This paper estimated that a given cortical astrocyte interacts with between 300 and 600 dendrites therefore its sphere of synaptic modulatory influence is quite large. However, the dendritic tree of a single neuron is ensheathed by many different astrocytes. This paper raises the concept of 'functional islands of synapses' influenced by signals from individual astrocytes.
-
Halassa M.M., Fellin T., Takano H., Dong J.H., and Haydon P.G. Synaptic islands defined by the territory of a single astrocyte. J Neurosci 27 (2007) 6473-6477. This paper estimated that a given cortical astrocyte interacts with between 300 and 600 dendrites therefore its sphere of synaptic modulatory influence is quite large. However, the dendritic tree of a single neuron is ensheathed by many different astrocytes. This paper raises the concept of 'functional islands of synapses' influenced by signals from individual astrocytes.
-
(2007)
J Neurosci
, vol.27
, pp. 6473-6477
-
-
Halassa, M.M.1
Fellin, T.2
Takano, H.3
Dong, J.H.4
Haydon, P.G.5
-
13
-
-
0033135292
-
Tripartite synapses: glia, the unacknowledged partner
-
Araque A., Parpura V., Sanzgiri R.P., and Haydon P.G. Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 22 (1999) 208-215
-
(1999)
Trends Neurosci
, vol.22
, pp. 208-215
-
-
Araque, A.1
Parpura, V.2
Sanzgiri, R.P.3
Haydon, P.G.4
-
14
-
-
0028867186
-
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
-
Meyer-Franke A., Kaplan M.R., Pfrieger F.W., and Barres B.A. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15 (1995) 805-819
-
(1995)
Neuron
, vol.15
, pp. 805-819
-
-
Meyer-Franke, A.1
Kaplan, M.R.2
Pfrieger, F.W.3
Barres, B.A.4
-
15
-
-
0030773837
-
Synaptic efficacy enhanced by glial cells in vitro
-
Pfrieger F.W., and Barres B.A. Synaptic efficacy enhanced by glial cells in vitro. Science 277 (1997) 1684-1687
-
(1997)
Science
, vol.277
, pp. 1684-1687
-
-
Pfrieger, F.W.1
Barres, B.A.2
-
16
-
-
0035875555
-
Glia-derived signals induce synapse formation in neurones of the rat central nervous system
-
Nagler K., Mauch D.H., and Pfrieger F.W. Glia-derived signals induce synapse formation in neurones of the rat central nervous system. J Physiol 533 (2001) 665-679
-
(2001)
J Physiol
, vol.533
, pp. 665-679
-
-
Nagler, K.1
Mauch, D.H.2
Pfrieger, F.W.3
-
18
-
-
13544273916
-
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
-
Christopherson K.S., Ullian E.M., Stokes C.C., Mullowney C.E., Hell J.W., Agah A., Lawler J., Mosher D.F., Bornstein P., and Barres B.A. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell 120 (2005) 421-433
-
(2005)
Cell
, vol.120
, pp. 421-433
-
-
Christopherson, K.S.1
Ullian, E.M.2
Stokes, C.C.3
Mullowney, C.E.4
Hell, J.W.5
Agah, A.6
Lawler, J.7
Mosher, D.F.8
Bornstein, P.9
Barres, B.A.10
-
19
-
-
70350368006
-
The gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for CNS synaptogenesis
-
How do astrocytes induce synapse formation? This paper identifies the calcium channel subunit α2δ-1 as the neuronal receptor for astrocyte-secreted synaptogenic signal thrombospondin. Authors propose a model in which α2δ-1 is the extracellular ligand-binding portion of a synaptogenic signaling complex. Upon TSP binding this complex is activated. Activation of this complex is crucial for the establishment of the initial axodendritic adhesion. A drug gabapentin that binds to α2δ-1 and inhibits TSP-α2δ-1 interaction, blocks synapse formation. These results identify α2δ-1 as a novel protein regulating synapse formation. In addition these results have important clinical implications as they highlight astrocytes and TSPs they produce as drug targets for treating diseases such as epilepsy and neuropathic pain.
-
Eroglu C., Allen N.J., Susman M.W., O'Rourke N.A., Young Park C., Özkan E., Chakraborty C., Mulinyawe S.B., Annis D.S., Huberman A.D., et al. The gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for CNS synaptogenesis. Cell 139 (2009) 380-392. How do astrocytes induce synapse formation? This paper identifies the calcium channel subunit α2δ-1 as the neuronal receptor for astrocyte-secreted synaptogenic signal thrombospondin. Authors propose a model in which α2δ-1 is the extracellular ligand-binding portion of a synaptogenic signaling complex. Upon TSP binding this complex is activated. Activation of this complex is crucial for the establishment of the initial axodendritic adhesion. A drug gabapentin that binds to α2δ-1 and inhibits TSP-α2δ-1 interaction, blocks synapse formation. These results identify α2δ-1 as a novel protein regulating synapse formation. In addition these results have important clinical implications as they highlight astrocytes and TSPs they produce as drug targets for treating diseases such as epilepsy and neuropathic pain.
-
(2009)
Cell
, vol.139
, pp. 380-392
-
-
Eroglu, C.1
Allen, N.J.2
Susman, M.W.3
O'Rourke, N.A.4
Young Park, C.5
Özkan, E.6
Chakraborty, C.7
Mulinyawe, S.B.8
Annis, D.S.9
Huberman, A.D.10
-
20
-
-
52549084801
-
Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke
-
It is a recurring theme that upon injury to the nervous system the expression of TSPs is upregulated (see also [21,22]). Initially the upregulation of TSPs after stroke was postulated to take part in post-ischemic angiogenesis. However, after the discovery that TSPs are involved in synapse formation in the CNS (see Christopherson et al. above [18]) Liauw et al. explored whether TSP1 and 2 were required for synaptic and functional recovery after stroke. They compared wild type and TSP1/2 double null mice mice for angiogenesis, synaptic density, axonal sprouting, infarct size, and functional recovery at different time points after stroke. No differences were found in infarct size and blood vessel density between the two groups after stroke suggesting angiogenesis was not significantly affected with the loss of TSPs. On the contrary TSP-1/2 KO mice exhibited a significant deficit in their ability to recover motor function
-
Liauw J., Hoang S., Choi M., Eroglu C., Sun G.H., Percy M., Wildman-Tobriner B., Bliss T., Guzman R.G., Barres B.A., et al. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metabol 28 (2008) 1722-1732. It is a recurring theme that upon injury to the nervous system the expression of TSPs is upregulated (see also [21,22]). Initially the upregulation of TSPs after stroke was postulated to take part in post-ischemic angiogenesis. However, after the discovery that TSPs are involved in synapse formation in the CNS (see Christopherson et al. above [18]) Liauw et al. explored whether TSP1 and 2 were required for synaptic and functional recovery after stroke. They compared wild type and TSP1/2 double null mice mice for angiogenesis, synaptic density, axonal sprouting, infarct size, and functional recovery at different time points after stroke. No differences were found in infarct size and blood vessel density between the two groups after stroke suggesting angiogenesis was not significantly affected with the loss of TSPs. On the contrary TSP-1/2 KO mice exhibited a significant deficit in their ability to recover motor function, in conjuction with significant synaptic density and axonal sprouting deficits.
-
(2008)
J Cereb Blood Flow Metabol
, vol.28
, pp. 1722-1732
-
-
Liauw, J.1
Hoang, S.2
Choi, M.3
Eroglu, C.4
Sun, G.H.5
Percy, M.6
Wildman-Tobriner, B.7
Bliss, T.8
Guzman, R.G.9
Barres, B.A.10
-
21
-
-
0142241383
-
Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development
-
Valder C.R., Liu J.J., Song Y.H., and Luo Z.D. Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development. J Neurochem 87 (2003) 560-573
-
(2003)
J Neurochem
, vol.87
, pp. 560-573
-
-
Valder, C.R.1
Liu, J.J.2
Song, Y.H.3
Luo, Z.D.4
-
22
-
-
0037063697
-
Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases
-
Wang H., Sun H., Della Penna K., Benz R.J., Xu J., Gerhold D.L., Holder D.J., and Koblan K.S. Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neuroscience 114 (2002) 529-546
-
(2002)
Neuroscience
, vol.114
, pp. 529-546
-
-
Wang, H.1
Sun, H.2
Della Penna, K.3
Benz, R.J.4
Xu, J.5
Gerhold, D.L.6
Holder, D.J.7
Koblan, K.S.8
-
23
-
-
36849076770
-
The classical complement cascade mediates CNS synapse elimination
-
This seminal work describes an unexpected function for the complement system in the CNS development and disease. They found that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response an unknown factor secreted by immature astrocytes. It is localized to synapses throughout the CNS during early postnatal development and its expression is downregulated in the adult. Mice deficient in complement protein C1q or the downstream complement protein C3 exhibited defects in CNS synapse elimination during the period of anatomical refinement of retinogeniculate connections. They also provided evidence that C1q-mediated synapse elimination might be an early event in neurodegenerative diseases such as glaucoma in which C1q expression is upregulated before synapse loss.
-
Stevens B., Allen N.J., Vazquez L.E., Howell G.R., Christopherson K.S., Nouri N., Micheva K.D., Mehalow A.K., Huberman A.D., Stafford B., et al. The classical complement cascade mediates CNS synapse elimination. Cell 131 (2007) 1164-1178. This seminal work describes an unexpected function for the complement system in the CNS development and disease. They found that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response an unknown factor secreted by immature astrocytes. It is localized to synapses throughout the CNS during early postnatal development and its expression is downregulated in the adult. Mice deficient in complement protein C1q or the downstream complement protein C3 exhibited defects in CNS synapse elimination during the period of anatomical refinement of retinogeniculate connections. They also provided evidence that C1q-mediated synapse elimination might be an early event in neurodegenerative diseases such as glaucoma in which C1q expression is upregulated before synapse loss.
-
(2007)
Cell
, vol.131
, pp. 1164-1178
-
-
Stevens, B.1
Allen, N.J.2
Vazquez, L.E.3
Howell, G.R.4
Christopherson, K.S.5
Nouri, N.6
Micheva, K.D.7
Mehalow, A.K.8
Huberman, A.D.9
Stafford, B.10
-
24
-
-
0035834416
-
CNS synaptogenesis promoted by glia-derived cholesterol
-
Mauch D.H., Nagler K., Schumacher S., Goritz C., Muller E.C., Otto A., and Pfrieger F.W. CNS synaptogenesis promoted by glia-derived cholesterol. Science 294 (2001) 1354-1357
-
(2001)
Science
, vol.294
, pp. 1354-1357
-
-
Mauch, D.H.1
Nagler, K.2
Schumacher, S.3
Goritz, C.4
Muller, E.C.5
Otto, A.6
Pfrieger, F.W.7
-
25
-
-
19444372396
-
Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron
-
Goritz C., Mauch D.H., and Pfrieger F.W. Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron. Mol Cell Neurosci 29 (2005) 190-201
-
(2005)
Mol Cell Neurosci
, vol.29
, pp. 190-201
-
-
Goritz, C.1
Mauch, D.H.2
Pfrieger, F.W.3
-
26
-
-
17044384571
-
Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors
-
Elmariah S.B., Oh E.J., Hughes E.G., and Balice-Gordon R.J. Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors. J Neurosci 25 (2005) 3638-3650
-
(2005)
J Neurosci
, vol.25
, pp. 3638-3650
-
-
Elmariah, S.B.1
Oh, E.J.2
Hughes, E.G.3
Balice-Gordon, R.J.4
-
27
-
-
1242271191
-
PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes
-
Hama H., Hara C., Yamaguchi K., and Miyawaki A. PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes. Neuron 41 (2004) 405-415
-
(2004)
Neuron
, vol.41
, pp. 405-415
-
-
Hama, H.1
Hara, C.2
Yamaguchi, K.3
Miyawaki, A.4
-
28
-
-
51149107860
-
Developmental control of synaptic receptivity
-
This study describes a very interesting finding that neurons are not born with the intrinsic ability to form synapses but acquire this ability upon contact with astrocytes. They showed that newly generated embryonic day 17 (E17) RGCs are able to form but not receive synapses even in the presence of astrocyte-secreted synaptogenic factors. The RGCs acquire the ability to receive synapses at E19 in response to direct contact by with astrocytes. They suggested that this receptivity upon contact is achieved by regulating the subcellular distribution of the pre-synaptic adhesion protein, neurexin. Upon contact with the astrocyte, neurexin, which inhibits synapse formation when present in the dendritic compartment, is sequestered in the axon away from dendrites.
-
Barker A.J., Koch S.M., Reed J., Barres B.A., and Ullian E.M. Developmental control of synaptic receptivity. J Neurosci 28 (2008) 8150-8160. This study describes a very interesting finding that neurons are not born with the intrinsic ability to form synapses but acquire this ability upon contact with astrocytes. They showed that newly generated embryonic day 17 (E17) RGCs are able to form but not receive synapses even in the presence of astrocyte-secreted synaptogenic factors. The RGCs acquire the ability to receive synapses at E19 in response to direct contact by with astrocytes. They suggested that this receptivity upon contact is achieved by regulating the subcellular distribution of the pre-synaptic adhesion protein, neurexin. Upon contact with the astrocyte, neurexin, which inhibits synapse formation when present in the dendritic compartment, is sequestered in the axon away from dendrites.
-
(2008)
J Neurosci
, vol.28
, pp. 8150-8160
-
-
Barker, A.J.1
Koch, S.M.2
Reed, J.3
Barres, B.A.4
Ullian, E.M.5
-
29
-
-
0037314984
-
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
-
[see comment]
-
Murai K.K., Nguyen L.N., Irie F., Yamaguchi Y., and Pasquale E.B. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci 6 (2003) 153-160 [see comment]
-
(2003)
Nat Neurosci
, vol.6
, pp. 153-160
-
-
Murai, K.K.1
Nguyen, L.N.2
Irie, F.3
Yamaguchi, Y.4
Pasquale, E.B.5
-
30
-
-
68149159282
-
Glial ephrin-3A regulates hippocampal dendritic spine morphology and glutamate transport
-
This recent study follows up the elegant work by Murai et al. [29] that showed that EphA4 receptor tyrosine kinase is in dendritic spines of pyramidal neurons of the adult hippocampus and regulates spine morphology. The authors show that ephrin-A3, which is located in the perisynaptic processes of astrocytes, is essential for maintaining spinal EphA4 activation and normal spine morphology in vivo. An unexpected and interesting finding of this paper is that glutamate transport is elevated in ephrin-A3-null hippocampal slices, whereas Eph-dependent stimulation of ephrin-A3 signaling inhibits glutamate transport. In addition, mice lacking ephrin-A3 or EphA4 showed impaired hippocampus-dependent learning. Taken together these results suggest that the interaction between neuronal EphA4 and glial ephrin-A3 bi-directionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function.
-
Carmona M.A.M.K., Wang L., Roberts A.J., and Pasqele E.B. Glial ephrin-3A regulates hippocampal dendritic spine morphology and glutamate transport. PNAS (2009). This recent study follows up the elegant work by Murai et al. [29] that showed that EphA4 receptor tyrosine kinase is in dendritic spines of pyramidal neurons of the adult hippocampus and regulates spine morphology. The authors show that ephrin-A3, which is located in the perisynaptic processes of astrocytes, is essential for maintaining spinal EphA4 activation and normal spine morphology in vivo. An unexpected and interesting finding of this paper is that glutamate transport is elevated in ephrin-A3-null hippocampal slices, whereas Eph-dependent stimulation of ephrin-A3 signaling inhibits glutamate transport. In addition, mice lacking ephrin-A3 or EphA4 showed impaired hippocampus-dependent learning. Taken together these results suggest that the interaction between neuronal EphA4 and glial ephrin-A3 bi-directionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function.
-
(2009)
PNAS
-
-
Carmona, M.A.M.K.1
Wang, L.2
Roberts, A.J.3
Pasqele, E.B.4
-
31
-
-
33748281357
-
Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses
-
Haber M., Zhou L., and Murai K.K. Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses. J Neurosci 26 (2006) 8881-8891
-
(2006)
J Neurosci
, vol.26
, pp. 8881-8891
-
-
Haber, M.1
Zhou, L.2
Murai, K.K.3
-
32
-
-
33846205911
-
Direct astrocytic contacts regulate local maturation of dendritic spines
-
Nishida H., and Okabe S. Direct astrocytic contacts regulate local maturation of dendritic spines. J Neurosci 27 (2007) 331-340
-
(2007)
J Neurosci
, vol.27
, pp. 331-340
-
-
Nishida, H.1
Okabe, S.2
-
33
-
-
1542722154
-
Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture
-
Ullian E.M., Harris B.T., Wu A., Chan J.R., and Barres B.A. Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neuroscie 25 (2004) 241-251
-
(2004)
Mol Cell Neuroscie
, vol.25
, pp. 241-251
-
-
Ullian, E.M.1
Harris, B.T.2
Wu, A.3
Chan, J.R.4
Barres, B.A.5
-
34
-
-
0038452670
-
Differential effects of neurotrophins and schwann cell-derived signals on neuronal survival/growth and synaptogenesis
-
Peng H.B., Yang J.F., Dai Z., Lee C.W., Hung H.W., Feng Z.H., and Ko C.P. Differential effects of neurotrophins and schwann cell-derived signals on neuronal survival/growth and synaptogenesis. J Neurosci 23 (2003) 5050-5060
-
(2003)
J Neurosci
, vol.23
, pp. 5050-5060
-
-
Peng, H.B.1
Yang, J.F.2
Dai, Z.3
Lee, C.W.4
Hung, H.W.5
Feng, Z.H.6
Ko, C.P.7
-
35
-
-
55749098985
-
Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1
-
Feng Z., and Ko C.P. Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. J Neurosci 28 (2008) 9599-9609
-
(2008)
J Neurosci
, vol.28
, pp. 9599-9609
-
-
Feng, Z.1
Ko, C.P.2
-
36
-
-
34250877405
-
Schwann cell-derived factors modulate synaptic activities at developing neuromuscular synapses
-
Cao G., and Ko C.P. Schwann cell-derived factors modulate synaptic activities at developing neuromuscular synapses. J Neurosci 27 (2007) 6712-6722
-
(2007)
J Neurosci
, vol.27
, pp. 6712-6722
-
-
Cao, G.1
Ko, C.P.2
-
37
-
-
0345119040
-
Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo
-
Reddy L.V., Koirala S., Sugiura Y., Herrera A.A., and Ko C.P. Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo. Neuron 40 (2003) 563-580
-
(2003)
Neuron
, vol.40
, pp. 563-580
-
-
Reddy, L.V.1
Koirala, S.2
Sugiura, Y.3
Herrera, A.A.4
Ko, C.P.5
-
38
-
-
45249096303
-
The role of glial cells in the formation and maintenance of the neuromuscular junction
-
pp. 19-28
-
Feng Z., and Ko C.P. The role of glial cells in the formation and maintenance of the neuromuscular junction. Ann NY Acad Sci 1132 (2008) pp. 19-28
-
(2008)
Ann NY Acad Sci
, vol.1132
-
-
Feng, Z.1
Ko, C.P.2
-
39
-
-
32044462033
-
Glial cell biology in Drosophila and vertebrates
-
Freeman M.R., and Doherty J. Glial cell biology in Drosophila and vertebrates. Trends Neurosci 29 (2006) 82-90
-
(2006)
Trends Neurosci
, vol.29
, pp. 82-90
-
-
Freeman, M.R.1
Doherty, J.2
-
40
-
-
35948942265
-
Neuron glial communication at synapses: insights from vertebrates and invertebrates
-
Murai K.K., and Van Meyel D.J. Neuron glial communication at synapses: insights from vertebrates and invertebrates. Neuroscientist 13 (2007) 657-666
-
(2007)
Neuroscientist
, vol.13
, pp. 657-666
-
-
Murai, K.K.1
Van Meyel, D.J.2
-
41
-
-
33749065988
-
Glia-neuron interactions in the nervous system of Caenorhabditis elegans
-
Shaham S. Glia-neuron interactions in the nervous system of Caenorhabditis elegans. Curr Opin Neurobiol 16 (2006) 522-528
-
(2006)
Curr Opin Neurobiol
, vol.16
, pp. 522-528
-
-
Shaham, S.1
-
42
-
-
35148813033
-
Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans
-
This seminal paper is the first to show that a factor from glia specifies the location of a synapse along an axon. UNC-6 (netrin) expressed by the ventral cephalic sheath glia localizes the UNC-40 netrin receptor on the pre-synaptic neuron to a particular region of the axon. This localization was shown to be sufficient for synapse formation at that site.
-
Colon-Ramos D.A., Margeta M.A., and Shen K. Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Science 318 (2007) 103-106. This seminal paper is the first to show that a factor from glia specifies the location of a synapse along an axon. UNC-6 (netrin) expressed by the ventral cephalic sheath glia localizes the UNC-40 netrin receptor on the pre-synaptic neuron to a particular region of the axon. This localization was shown to be sufficient for synapse formation at that site.
-
(2007)
Science
, vol.318
, pp. 103-106
-
-
Colon-Ramos, D.A.1
Margeta, M.A.2
Shen, K.3
-
43
-
-
55349134868
-
Glia are essential for sensory organ function in C. elegans
-
Bacaj T., Tevlin M., Lu Y., and Shaham S. Glia are essential for sensory organ function in C. elegans. Science 322 (2008) 744-747
-
(2008)
Science
, vol.322
, pp. 744-747
-
-
Bacaj, T.1
Tevlin, M.2
Lu, Y.3
Shaham, S.4
|