Chemical interactions with pyramidal neurons in layer 5 of the cerebral cortex: Control of pain and anxiety

Current Medicinal Chemistry

Volumn 16, Issue 27, 2009, Pages 3476-3479

  Adams Jr , J D ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Anxiety; Comfort; Muscarinic peptides; Nicotinic peptides; Pain; Serotonergic peptides

Indexed keywords

ERGOT ALKALOID; KININ; MESCALINE; MUSCARINIC RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; OPIATE; OPIATE RECEPTOR; PLACEBO; PSILOCYBINE; SALVINORIN A; SCOPOLAMINE; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANALGESIA; ANXIETY; BRAIN CORTEX; CHEMICAL INTERACTION; DEPRESSION; HUMAN; MUSCLE RELAXATION; NEUROTRANSMISSION; PAIN; PROTEIN FUNCTION; PSYCHOSIS; PYRAMIDAL NERVE CELL; RESPIRATION DEPRESSION; REVIEW; STRUCTURE ACTIVITY RELATION; UNPLEASANT DREAM;

ANXIETY; CEREBRAL CORTEX; NEURONS; NEUROTRANSMITTER AGENTS; PAIN; PEPTIDES; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN, 5-HT2;

EID: 70450202643     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709789057626     Document Type: Review

References (16)

1. Garcia, C.; Adams, J.D. Healing with medicinal plants of the west - cultural and scientific basis for their use second edition, Abedus Press: La Crescenta, 2009.
2. Marek, G.J.: Aghajanian, G. 5-Hydroxytryptamine induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by uopiate receptor activation. Neuroscience, 1998, 86, 485-497
3. Wang, Z.; Kai, L.; Day, M.; Ronesi, J.; Yin, H.; Ding, J.; Tkatch, T.; Lovinger, D.; Surmeier, D. Dopaminergic control of corticostriatal long term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron, 2006, 50, 443-452
4. Dringenberg, H.C.; Yahia, N.; Cirasuolo, J.; McKee, D.; Kuo, M. Neocortical activation by electrical and chemical stimulation of the rat inferior colliculus: intra-collicular mapping and neuropharmacological characterization. Exp. Brain Res., 2004,154, 461-469 (Pubitemid 38293736)
5. Poeaknapo, C.; Schmidt, J.; Brandsch, M.; Drager, B.; Zenk, M. Endogenous formation of morphine in human cells. Proc. Natl. Acad. Sci. USA, 2004, 101, 14091-14096 (Pubitemid 39305035)
6. Li, Y.; Husbands, S.; Mahon, M.; Traynor, J.; Rowan, M. Isolation and chemical modification of clerodane diterpenoids from Salvia species as potential agonists at the kappa opioid receptor. Chem. Diodivers., 2007, 4, 1586-1593
7. Helsley, S.; Rabin, R.; Winter, J. Drug discrimination studies with ibogaine. Alkaloids Chem. Biol., 2001, 56, 63-77.
8. Sweetman, P.; Lancaster, J.; Snowman, A.; Collins, J.; Perschke, S.; Bauer, C.; Ferkany, J. Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity. Psychopharmacology, 1995, 118, 369-376
9. Piek, T. Neurotoxins from venoms of the hymenoptera - twenty five years of research in Amsterdam. Comp. Biochem. Physiol., 1990, 96C, 223-233
10. Gobbo, M.; Biondi, L.; Filira, F.; Rocchi, R.; Piek, T. Cyclic analogues of wasp kinins from Vespa analis and Vespa tropica. Int. J. Pep. Protein Res., 1995, 45, 282-289
11. Cucchiaro, G.; Xiao, Y.; Gonzalez-Suiser, A.; Kellar, K. Analgesic effects of sazetidine-A, a new nicotinic cholinergic drug. Anesthesiology, 2008, 109, 512-519
12. Jerusalinsky, D.; Cervenansky, C.; Walz, R.; Bianchin, M.; Izquierdo, I. A peptide muscarinic toxin from the green mamba shows agonist like action in an inhibitory avoidance learning task. Eur. J. Pharmacol., 1993, 240, 103-105 (Pubitemid 23238083)
13. Fruchart-Gaillard, C.; Mourier, G.; Marquer, C.; Stura, E.; Birdsall, N.; Servent, D. Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine occupied states. Mol. Pharmacol., 2008, 74, 1554-1563
14. Kukkonen, A.; Perakyla, M.; Akerman, K.; Nasman, J. Muscarinic toxin 7 selectivity is dictated by extracellular receptor loops. J. Biol. Chem., 2004, 279, 50923-50929 (Pubitemid 40017831)
15. Uhlig, S.; Petersen, D. Lactam ergot alkaloids (ergopeptams) as predominant alkaloids in sclerotia of Claviceps purpurea from Norwegian wild grasses. Toxicon, 2008, 52, 175-185
16. Marangell, L.; Dennehy, E.; Wisniewski, S.; Bauer, M.; Miyahara, S.; Allen, M.; Martinez, M.; Al Jurdi, R.; Thase, M. Case control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD. J. Clin. Psychiatry, 2008, 69, 916-922