Comparison of genetic polymorphisms of the NAT2 gene between Korean and four other ethnic groups

Journal of Clinical Pharmacy and Therapeutics

Volumn 34, Issue 6, 2009, Pages 709-718

  Kang, T S ^a   Jin, S K ^a   Lee, J E ^b   Woo, S W ^a   Roh, J ^c  

^a Korea Food and Drug Administration   (South Korea)

^b DNA Link Inc   (South Korea)

^c Hanyang University Medical Center   (South Korea)

Author keywords

International HapMap; NAT2; Pharmacogenetics; Polymorphisms

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; GENOMIC DNA;

AFRICA; ALGORITHM; ALLELE; ARTICLE; ASIAN; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; COMPARATIVE STUDY; DATA BASE; DNA SEQUENCE; ETHNIC DIFFERENCE; ETHNIC GROUP; EUROPE; EXON; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HAPLOTYPE MAP; KOREA; NAT2 GENE; OBSERVATIONAL STUDY; PHARMACODYNAMICS; POPULATION; PREDICTION; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; ARYLAMINE N-ACETYLTRANSFERASE; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; NEOPLASMS; POLYMORPHISM, GENETIC;

EID: 70450170546     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2009.01065.x     Document Type: Article

References (23)

1. Sabbagh A, Darlu P (2005) Inferring haplotypes at the NAT2 locus: the computational approach. BMC Genetics, 6, 30.
2. Vatsis KP, Martell KJ, Weber WW (1991) Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 88, 6333 6337.
3. Hein DW (2006) N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk. Oncogene, 25, 1649 1658.
4. Hein DW (2002) Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutation Research, 506-507, 65 77.
5. Fretland AJ, Leff MA, Doll MA, Hein DW (2001) Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms. Pharmacogenetics, 11, 207 215.
6. Hein DW, Fretland AJ, Doll MA (2006) Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens. International journal of cancer, 119, 1208 1211.
7. Patin E, Harmant C, Kidd KK, et al. (2006) Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene. Human Mutation, 27, 720.
8. Rabstein S, Unfried K, Ranft U, Illig T, Kolz M, Rihs HP et al. (2006) Variation of the N-acetyltransferase 2 gene in a Romanian and a Kyrgyz population. Cancer Epidemiology, Biomarkers and Prevention, 15, 138 141.
9. Sabbagh A, Langaney A, Darlu P, Gerard N, Krishnamoorthy R, Poloni ES (2008) Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history. BMC Genetics, 9, 21.
10. Delomenie C, Sica L, Grant DM, Krishnamoorthy R, Dupret JM (1996) Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations. Pharmacogenetics, 6, 177 185.
11. Goldstein DB, Ahmadi KR, Weale ME, Wood NW (2003) Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. Trends in Genetics, 19, 615 622.
12. Jin SK, Kang TS, Um SO, Kim J-I, Lee HJ, Roh J (2009) CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole. Journal of Clinical Pharmacy and Therapeutics, In press. Accept (29 July 2008).
13. Woo SW, Kang TS, Park HJ, Lee Y, Lee JE, Roh J (2009) Comparison of linkage disequilibrium patterns and haplotype structure of 8 single nucleotide polymorphisms across the CYP1A2 gene between the Korean, and other populations registered in the International HapMap database. Journal of Clinical Pharmacy and Therapeutics, In press. Accept (24 September 2008).
14. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (Oxford, England), 21, 263 265.
15. Ardlie KG, Kruglyak L, Seielstad M (2002) Patterns of linkage disequilibrium in the human genome. Nature Reviews, 3, 299 309.
16. Garcia-Martin E (2008) Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Current Drug Metabolism, 9, 487 497.
17. Ilett KF, Kadlubar FF, Minchin RF (1998) International meeting on the arylamine N-acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons, and role in human disease risk. Drug Metabolism and Disposition: The Biological Fate of Chemicals, 27, 957 959.
18. Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM et al. (1995) Nomenclature for N-acetyltransferases. Pharmacogenetics, 5, 1 17.
19. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xiao GH et al. (2000) Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiology, Biomarkers and Prevention, 9, 29 42.
20. Rothman N, Stewart WF, Caporaso NE, Hayes RB (1993) Misclassification of genetic susceptibility biomarkers: implications for case-control studies and cross-population comparisons. Cancer Epidemiology, Biomarkers and Prevention, 2, 299 303.
21. Yuliwulandari R, Sachrowardi Q, Nishida N, Takasu M, Batubara L, Susmiarsih TP et al. (2008) Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population: proposal for a new nomenclature. Journal of Human Genetics, 53, 201 209.
22. Zang Y, Doll MA, Zhao S, States JC, Hein DW (2007) Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis, 28, 1665 1671. (Pubitemid 47289027)
23. Hurley JD, Engle LJ, Davis JT, Welsh AM, Landers JE (2004) A simple, bead-based approach for multi-SNP molecular haplotyping. Nucleic Acids Research, 32, e186.