Improving outcomes in critically ill patients: The seduction of physiology

JAMA

Volumn 302, Issue 18, 2009, Pages 2030-2032

  Slutsky, Arthur S ^a,b,c,d  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; BODY POSTURE; EDITORIAL; HUMAN; HYPOXEMIA; LUNG INJURY; MORTALITY; OXYGEN SATURATION; OXYGEN TOXICITY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PRONE POSITIONING; TIDAL VOLUME;

ACUTE LUNG INJURY; CLINICAL TRIALS AS TOPIC; CRITICAL ILLNESS; HUMANS; PRONE POSITION; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY PHYSIOLOGICAL PHENOMENA;

EID: 70449955534     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2009.1653     Document Type: Editorial

References (20)

1. Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685-1693. (Pubitemid 41464707)
2. Tremblay LN, Slutsky AS. Ventilator-induced lung injury: from the bench to the bedside. Intensive Care Med. 2006;32(1):24-33. (Pubitemid 43039374)
3. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301-1308. (Pubitemid 30408714)
4. Bryan AC. Conference on the scientific basis of respiratory therapy: pulmonary physiotherapy in the pediatric age group: comments of a devil's advocate. Am Rev Respir Dis. 1974;110(6, pt 2):143-144.
5. Taccone P, Pesenti A, Latini R, et al; for the Prone-Supine II Study Group. Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2009;302(18):1977-1984.
6. Sud S, Sud M, Friedrich JO, Adhikari NK. Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis. CMAJ. 2008;178(9):1153-1161. (Pubitemid 351580074)
7. Tiruvoipati R, Bangash M, Manktelow B, Peek GJ. Efficacy of prone ventilation in adult patients with acute respiratory failure: a meta-analysis. J Crit Care. 2008;23(1):101-110.
8. Abroug F, Ouanes-Besbes L, Elatrous S, Brochard L. The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis: areas of uncertainty and recommendations for research. Intensive Care Med. 2008;34(6):1002-1011. (Pubitemid 351903798)
9. Alsaghir AH, Martin CM. Effect of prone positioning in patients with acute respiratory distress syndrome: a meta-analysis. Crit Care Med. 2008;36(2):603-609. (Pubitemid 351158639)
10. Albert RK. Prone ventilation. Clin Chest Med. 2000;21(3):511-517.
11. Mancebo J, Fernandez R, Blanch L, et al. A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006;173(11):1233-1239. (Pubitemid 43848394)
12. Guérin C, Gaillard S, Lemasson S, et al. Effects of systematic prone positioning in acute hypoxemic respiratory failure: a randomized controlled trial. JAMA. 2004;292(19):2379-2387.
13. Gattinoni L, Tognoni G, Pesenti A, et al; Prone-Supine Study Group. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med. 2001;345(8):568-573.
14. Messerole E, Peine P, Wittkopp S, Marini JJ, Albert RK. The pragmatics of prone positioning. Am J Respir Crit Care Med. 2002;165(10):1359-1363.
15. Epstein AE, Hallstrom AP, Rogers WJ, et al; the CAST Investigators. Mortality following ventricular arrhythmia suppression by encainide, flecainide, and moricizine after myocardial infarction: the original design concept of the Cardiac Arrhythmia Suppression Trial (CAST). JAMA. 1993;270(20):2451-2455.
16. Dellinger RP, Vincent JL, Marshall J, Reinhart K. Important issues in the design and reporting of clinical trials in severe sepsis and acute lung injury. J Crit Care. 2008;23(4):493-499.
17. Mélot C. New designs for clinical trials. Crit Care Med. 2009;37(1 suppl):S59-S64.
18. Peto R, Baigent C. Trials: the next 50 years: large scale randomised evidence of moderate benefits. BMJ. 1998;317(7167):1170-1171.
19. Edwards P, Arango M, Balica L, et al; CRASH Trial Collaborators. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet. 2005;365(9475):1957-1959.
20. InFACT Web site. http://www.infactglobal.org. Accessibility verified October 14, 2009.