Mechanisms of lymphocyte loss in SARS coronavirus infection

Hong Kong Medical Journal

Volumn 14, Issue SUPP4, 2008, Pages 21-26

  Chan, Paul K S ^a   Chen, G G ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

APOPTOSIS; ARTICLE; CELL CULTURE; COCULTURE; COMPARATIVE STUDY; CYTOPATHOGENIC EFFECT; HUMAN; IMMUNOLOGY; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; METABOLISM; MONOCYTE; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE; SARS CORONAVIRUS; SENSITIVITY AND SPECIFICITY; SEVERE ACUTE RESPIRATORY SYNDROME; T LYMPHOCYTE;

ANTIBODIES, VIRAL; APOPTOSIS; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOPATHOGENIC EFFECT, VIRAL; HUMANS; LYMPHOCYTE COUNT; LYMPHOPENIA; MONOCYTES; REFERENCE VALUES; RNA, VIRAL; SARS VIRUS; SENSITIVITY AND SPECIFICITY; SEVERE ACUTE RESPIRATORY SYNDROME; T-LYMPHOCYTES; VIRAL ENVELOPE PROTEINS;

EID: 70449924211     PISSN: 10242708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Wong RS, Wu A, To KF, et al. Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis. BMJ 2003;326:1358-62.
2. Collins AR. In vitro detection of apoptosis in monocytes/macrophages infected with human coronavirus. Clin Diagn Lab Immunol 2002;9:1392-5.
3. Panesar NS, Lam CW, Chan MH, Wong CK, Sung JJ. Lymphopenia and neutrophilia in SARS are related to the prevailing serum cortisol. Eur J Clin Invest 2004;34:382-4.
4. Li L, Wo J, Shao J, et al. SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients. J Clin Virol 2003;28:239-44.
5. Chen RF, Chang JC, Yeh WT, et al. Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS). Microbes Infect 2006;8:122-7.