Surface treatment with 5-fluorouracil after flexor tendon repair in a canine in vivo model

Journal of Bone and Joint Surgery

Volumn 91, Issue 11, 2009, Pages 2673-2682

  Zhao, Chunfeng ^a   Zobitz, Mark E ^a   Sun, Yu Long ^a   Predmore, Kelly S ^a   Amadio, Peter C ^a   An, Kai Nan ^a   Moran, Steven L ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; FIBRONECTIN; FLUOROURACIL; TRANSFORMING GROWTH FACTOR BETA1;

ADHESION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; EXPERIMENTAL MODEL; FLEXOR DIGITORUM PROFUNDUS; FLEXOR MUSCLE; FLEXOR TENDON; FLEXOR TENDON INJURY; GENE EXPRESSION; HISTOLOGY; IN VIVO STUDY; INNERVATION; LACERATION; MUSCLE STIFFNESS; MUSCLE STRENGTH; NEURECTOMY; NONHUMAN; NUCLEOTIDE SEQUENCE; PASSIVE MOVEMENT; POSTOPERATIVE ADHESION; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REHABILITATION CARE; SURVIVAL TIME; TENDON RECONSTRUCTION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIMETABOLITES; DOGS; FLUOROURACIL; MUSCULOSKELETAL DISEASES; TENDON INJURIES; TISSUE ADHESIONS;

EID: 70449788257     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/JBJS.H.01695     Document Type: Article

References (27)

1. Momose T, Amadio PC, Zhao C, Zobitz ME, Couvreur PJ, An KN. Suture techniques with high breaking strength and low gliding resistance: experiments in the dog flexor digitorum profundus tendon. Acta Orthop Scand. 2001;72: 635-641
2. Zhao C, Amadio PC, Momose T, Couvreur P, Zobitz ME, An KN. The effect of suture technique on adhesion formation after flexor tendon repair for partial lacerations in a canine model. J Trauma. 2001;51:917-921
3. Tanaka T, Amadio PC, Zhao C, Zobitz ME, Yang C, An KN. Gliding characteristics and gap formation for locking and grasping tendon repairs: a biomechanical study in a human cadaver model. J Hand Surg Am. 2004;29:6-14. (Pubitemid 38146395)
4. Silfverskiöld KL, May EJ, Törnvall AH. Tendon excursions after flexor tendon repair in zone. II: Results with a new controlled-motion program. J Hand Surg Am. 1993;18:403-410 (Pubitemid 23175836)
5. Zhao C, Amadio PC, Momose T, Couvreur P, Zobitz ME, An KN. Effect of synergistic wrist motion on adhesion formation after repair of partial flexor digitorum profundus tendon lacerations in a canine model in vivo. J Bone Joint Surg Am. 2002;84:78-84. (Pubitemid 34906762)
6. Klein L. Early active motion flexor tendon protocol using one splint. J Hand Ther. 2003;16:199-206. (Pubitemid 36976066)
7. Frykman E, Jacobsson S, Widenfalk B. Fibrin sealant in prevention of flexor tendon adhesions: an experimental study in the rabbit. J Hand Surg Am. 1993;18: 68-75. (Pubitemid 23065274)
8. Burns JW, Skinner K, Colt MJ, Burgess L, Rose R, Diamond MP. A hyaluronate based gel for the prevention of postsurgical adhesions: evaluation in two animal species. Fertil Steril. 1996;66:814-821 (Pubitemid 26357588)
9. Shih HN, Fang JF, Chen JH, Yang CL, Chen YH, Sung TH, Shih LY. Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane. J Biomed Mater Res B Appl Biomater. 2004;71:421-428
10. Hagberg L. Exogenous hyaluronate as an adjunct in the prevention of adhesions after flexor tendon surgery: a controlled clinical trial. J Hand Surg Am. 1992;17:132-136
11. Hills BA. Boundary lubrication in vivo. Proc Inst Mech Eng H. 2000;214:83-94.
12. Zhao C, Sun YL, Amadio PC, Tanaka T, Ettema AM, An KN. Surface treatment of flexor tendon autograft with carbodiimide-derivatized hyaluronic acid. An in vivo canine model. J Bone Joint Surg Am. 2006;88:2181-2191 (Pubitemid 44536780)
13. Namba J, Shimada K, Saito M, Murase T, Yamada H, Yoshikawa H. Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model. J Biomed Mater Res B Appl Biomater. 2007;80:273-279 (Pubitemid 46034432)
14. Occleston NL, Alexander RA, Mazure A, Larkin G, Khaw PT. Effects of single exposures to antiproliferative agents on ocular fibroblast-mediated collagen contraction. Invest Ophthalmol Vis Sci. 1994;35:3681-3690 (Pubitemid 24337981)
15. Moran SL, Ryan CK, Orlando GS, Pratt CE, Michalko KB. Effects of 5-fluorouracil on flexor tendon repair. J Hand Surg Am. 2000;25:242-251 (Pubitemid 30165587)
16. Khaw PT, Sherwood MB, MacKay SL, Rossi MJ, Schultz G. Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts. Arch Ophthalmol. 1992;110:1150-1154
17. Akali A, Khan U, Khaw PT, McGrouther AD. Decrease in adhesion formation by a single application of 5-fluorouracil after flexor tendon injury. Plast Reconstr Surg. 1999;103:151-158 (Pubitemid 29018844)
18. Cerovac S, Afoke A, Akali A, McGrouther DA. Early breaking strength of repaired flexor tendon treated with 5-fluorouracil. J Hand Surg Br. 2001;26:220-223 (Pubitemid 32586299)
19. Okuda Y, Gorski JP, An KN, Amadio PC. Biochemical, histological, and biomechanical analyses of canine tendon. J Orthop Res. 1987;5:60-68 (Pubitemid 17038855)
20. Tanaka T, Amadio PC, Zhao C, Zobitz ME, An KN. Flexor digitorum profundus tendon tension during finger manipulation. J Hand Ther. 2005;18:330-338
21. Zhao C, Amadio PC, Tanaka T, Yang C, Ettema AM, Zobitz ME, An KN. Shortterm assessment of optimal timing for postoperative rehabilitation after flexor digitorum profundus tendon repair in a canine model. J Hand Ther. 2005;18:322-329 (Pubitemid 41019236)
22. Uchiyama S, Amadio PC, Coert JH, Berglund LJ, An KN. Gliding resistance of extrasynovial and intrasynovial tendons through the A2 pulley. J Bone Joint Surg Am. 1997;79:219-224 (Pubitemid 27108047)
23. Zhao C, Amadio PC, Zobitz ME, An KN. Gliding characteristics of tendon repair in canine flexor digitorum profundus tendons. J Orthop Res. 2001;19:580-586 (Pubitemid 32700971)
24. Zhao CF, Amadio PC, Berglund L, Zobitz ME, An KN. A new testing device for measuring gliding resistance and work of flexion in a digit. J Biomech. 2003;36:295-299 (Pubitemid 36110594)
25. Zhao C, Amadio PC, Momose T, Zobitz ME, Couvreur P, An KN. Remodeling of the gliding surface after flexor tendon repair in a canine model in vivo. J Orthop Res. 2002;20:857-862 (Pubitemid 34823009)
26. Silva MJ, Brodt MD, Boyer MI, Morris TS, Dinopoulos H, Amiel D, Gelberman RH. Effects of increased in vivo excursion on digital range of motion and tendon strength following flexor tendon repair. J Orthop Res. 1999;17: 777-783
27. Wada A, Kubota H, Miyanishi K, Hatanaka H, Miura H, Iwamoto Y. Comparison of postoperative early active mobilization and immobilization in vivo utilising a fourstrand flexor tendon repair. J Hand Surg Br. 2001;26:301-306 (Pubitemid 32754952)