Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands

Biochemical and Biophysical Research Communications

Volumn 389, Issue 3, 2009, Pages 420-425

  Rullinkov, Grete ^a   Tamme, Richard ^a   Sarapuu, Anzelika ^a   Laurén, Juha ^b   Sepp, Mari ^a   Palm, Kaia ^a   Timmusk, Tõnis ^a,b  

^a TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Delta; Neuralized; Neurogenic gene; Notch; Proneural gene

Indexed keywords

MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN DLL1; PROTEIN DLL4; UNCLASSIFIED DRUG; DLK1 PROTEIN, HUMAN; DLL4 PROTEIN, HUMAN; LIGAND; MUSCLE PROTEIN; NEURL2 PROTEIN, HUMAN; SIGNAL PEPTIDE; UBIQUITIN PROTEIN LIGASE;

ALTERNATIVE RNA SPLICING; ARTICLE; DENDRITE; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE STRUCTURE; GENETIC TRANSCRIPTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MUTATOR GENE; NEUR2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; ANIMAL; BRAIN; CYTOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE; NERVE CELL; PRENATAL DEVELOPMENT;

MAMMALIA; RODENTIA;

ANIMALS; BRAIN; HIPPOCAMPUS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MICE; MUSCLE PROTEINS; NEURONS; RATS; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 70449732285     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.147     Document Type: Article

References (27)

1. A.C. Tien, A. Rajan, H.J. Bellen, A Notch updated, J. Cell Biol. 184 (2009) 621-629.
2. M.E. Fortini, Notch signaling: the core pathway and its posttranslational regulation, Dev. Cell 16 (2009) 633-647.
3. E.C. Lai, G.A. Deblandre, C. Kintner, G.M. Rubin, Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta, Dev. Cell 1 (2001) 783-794.
4. E. Yeh, M. Dermer, C. Commisso, L. Zhou, L.C.J. McGlade, G.L. Boulianne, Neuralized functions as and E3 ligase during Drosophila development, Curr. Biol. 11 (2001) 1675-1679.
5. R. Le Borgne, S. Remaud, S. Hamel, F. Schweisguth, Two distinct E3 ubiquitin ligases have complementary functions in the regulation of Delta and Serrate signaling in Drosophila, PLoS Biol. 3 (2005) e96.
6. M. Fürthauer, M. González-Gaitán, Endocytic regulation of Notch signalling during development, Traffic 10 (2009) 792-802.
7. B. Vollrath, J. Pudney, S. Asa, P. Leder, K. Fitzgerald, Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland, Mol. Cell Biol. 21 (2001) 7481-7494.
8. Y. Ruan, L. Tecott, M.M. Jiang, L.Y. Jan, Y.N. Jan, Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized, Proc. Natl. Acad. Sci. USA 98 (2001) 9907-9912.
9. E. Koutelou, S. Sato, C. Tomomori-Sato, L. Florens, S.K. Swanson, M.P. Washburn, M. Kokkinaki, R.C. Conaway, J.W. Conaway, N.K. Moschonas, Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1, J. Biol. Chem. 283 (2008) 3846-3853.
10. R. Song, B.K. Koo, K.J. Yoon, M.J. Yoon, K.W. Yoo, H.T. Kim, H.J. Oh, Y.Y. Kim, J.K. Han, C.H. Kim, Y.Y. Kong, Neuralized-2 regulates a Notch ligand in cooperation with Mind-bomb-1, J. Biol. Chem. 281 (2006) 36391-36400.
11. J.C. Barsi, R. Rajendra, J.I. Wu, K. Artzt, Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling, Mech. Dev. 122 (2005) 1106-1117.
12. B.K. Koo, H.S. Lim, R. Song, M.J. Yoon, K.J. Yoon, J.S. Moon, Y.W. Kim, M.C. Kwon, K.W. Yoo, M.P. Kong, J. Lee, A.B. Chitnis, C.H. Kim, Y.Y. Kong, Mind bomb 1 is essential for generating functional Notch ligands to activate Notch, Development 132 (2005) 3459-3470.
13. B.K. Koo, M.J. Yoon, K.J. Yoon, S.K. Im, Y.Y. Kim, C.H. Kim, P.G. Suh, Y.N. Jan, Y.Y. Kong, An obligatory role of Mind bomb-1 in Notch signaling of mammalian development, PLoS ONE 2 (2007) e1221.
14. B.K. Koo, K.J. Yoon, K.W. Yoo, H.S. Lim, R. Song R, J.H. So, C.H. Kim, Y.Y. Kong, Mind bomb-2 is an E3 ligase for Notch ligand, J. Biol. Chem. 280 (2005) 22335-22342.
15. T. Timmusk, K. Palm, N. Belluardo, G. Mudò, T. Neuman, Dendritic localization of mammalian Neuralized mRNA encoding a protein with transcription repression activities, Mol. Cell Neurosci. 20 (2002) 649-668.
16. C. Commisso, G.L. Boulianne, The Neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and Deltadependent inhibition of nuclear import, J. Mol. Biol. 375 (2008) 1125-1140.
17. R. Jurd, C. Thornton, J. Wang, K. Luong, K. Phamluong, V. Kharazia, S.L. Gibb, D. Ron, Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner, J. Biol. Chem. 283 (2008) 301-310.
18. P. Pruunsild, A. Kazantseva, T. Aid, K. Palm, T. Timmusk, Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters, Genomics 90 (2007) 397-406.
19. H. Vihma, P. Pruunsild, T. Timmusk, Alternative splicing and expression of human and mouse NFAT genes, Genomics 92 (2008) 279-291.
20. A. Kazantseva, M. Sepp, J. Kazantseva, H. Sadam, P. Pruunsild, T. Timmusk, T. Neuman, K. Palm, N-terminally truncated BAF57 isoforms contribute to the diversity of SWI/SNF complexes in neurons, J. Neurochem. 109 (2009) 807-818.
21. J. Laurén, M.S. Airaksinen, M. Saarma, T. Timmusk, A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system, Genomics 81 (2003) 411-421.
22. C.R. Bramham, D.G. Wells, Dendritic mRNA: transport, translation and function, Nat. Rev. Neurosci. 8 (2007) 776-789.
23. J.R. Shutter, S. Scully, W. Fan, W.G. Richards, J. Kitajewski, G.A. Deblandre, C.R. Kintner, K.L. Stark, Dll4, a novel Notch ligand expressed in arterial endothelium, Genes Dev. 14 (2000) 1313-1318.
24. F.N. Karanu, B. Murdoch, T. Miyabayashi, M. Ohno, M. Koremoto, L. Gallacher, D. Wu, A. Itoh, S. Sakano, M. Bhatia, Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells, Blood 97 (2001) 1960-1967.
25. C.E. Bland, P. Kimberly, M.D. Rand, Notch-induced proteolysis and nuclear localization of the Delta ligand, J. Biol. Chem. 278 (2003) 13607-13610.
26. M.J. LaVoie, D.J. Selkoe, The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments, J. Biol. Chem. 278 (2003) 34427-34437.
27. C. Commisso, G.L. Boulianne, The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling, Mol. Biol. Cell 18 (2007) 1-13.