Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells

Journal of Allergy and Clinical Immunology

Volumn 124, Issue 4, 2009, Pages 793-800

  Somech, Raz ^a   Simon, Amos J ^a   Lev, Atar ^a   Dalal, Ilan ^b,c   Spirer, Zvi ^a   Goldstein, Itamar ^a   Nagar, Meital ^a   Amariglio, Ninette ^a   Rechavi, Gideon ^a   Roifman, Chaim M ^d  

^a SHEBA MEDICAL CENTER   (Israel)

^b WOLFSON MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d Canadian Centre for Primary Immunodeficiency   (Canada)

Author keywords

AIRE; autoimmunity; Foxp3; immunodeficiency; oligoclones; Omenn syndrome; SCID; tolerance; TREC; Treg

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CD4 ANTIGEN; DNA; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; AUTOIMMUNITY; BLOOD; CELL EXPANSION; CELL MATURATION; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA RECOMBINATION; GENE; GENE EXPRESSION; GENETIC DISORDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; MALE; NATURAL KILLER T CELL; OMENN SYNDROME; POPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMUS; CD4+ T LYMPHOCYTE; CELL CLONE; DOWN REGULATION; FEMALE; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; METABOLISM; SEVERE COMBINED IMMUNODEFICIENCY; UPREGULATION;

AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; CYTOKINES; DOWN-REGULATION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE REARRANGEMENT, T-LYMPHOCYTE; HUMANS; IMMUNE TOLERANCE; MALE; RECEPTORS, ANTIGEN, T-CELL; SEVERE COMBINED IMMUNODEFICIENCY; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 70449732278     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.06.048     Document Type: Article

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