Modic changes, possible causes and promotion to lumbar intervertebral disc degeneration

Medical Hypotheses

Volumn 73, Issue 6, 2009, Pages 930-932

  Hu, Zhi Jun ^a   Zhao, Feng Dong ^a   Fang, Xiang Qian ^a   Fan, Shun Wu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOMECHANICS; BONE MARROW DISEASE; DIETARY INTAKE; DISEASE ASSOCIATION; HUMAN; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; LOW BACK PAIN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

BIOMECHANICS; BONE MARROW; HUMANS; INTERVERTEBRAL DISK DEGENERATION; LUMBAR VERTEBRAE;

EID: 70449727937     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.06.038     Document Type: Article

References (31)

1. de Roos A., Kresse H., Spritzer C., and Dalinka M. MRI imaging of marrow changes adjacent to endplates in degenerative lumbar disc disease. AJR Am J Roentgenol 149 (1987) 531-534
2. Modic M.T., Steinberg P.M., Ross J.S., Masaryk T.J., and Carter J.R. Degenerative disc disease: assessment of changes in vertebral body marrow with MRI imaging. Radiology 166 (1988) 194-199
3. Modic M.T., Masaryk T.J., Ross J.S., and Carter J.R. Imaging of degenerative disk disease. Radiology 168 (1988) 177-186
4. Braithwaite I., White J., Saifuddin A., Renton P., and Taylor B.A. Vertebral endplate (Modic) changes on lumbar spine MRI: correlation with pain reproduction at lumbar discography. Eur Spine J 7 (1998) 363-368
5. Karchevsky M., Schweitzer M.E., Carrino J.A., Zoga A., Montgomery D., and Parker L. Reactive endplate marrow changes: a systematic morphologic and epidemiologic evaluation. Skeletal Radiol 34 3 (2005) 125-129
6. Albert H.B., Kjaer P., Jensen T.S., Sorensen J.S., Bendix T., and Manniche C. Modic changes, possible causes and relation to low back pain. Med Hypotheses 70 2 (2008) 361-368
7. Schmid G., Witteler A., Willburger R., Kuhnen C., Jergas M., and Koester O. Lumbar disk herniation: correlation of histologic findings with marrow signal intensity changes in vertebral endplates at MR imaging. Radiology 231 2 (2004) 352-358
8. Tanaka M., Nakahara S., and Inoue H. A pathologic study of discs in the elderly: separation between the cartilaginous endplate and the vertebral body. Spine 18 (1993) 1456-1462
9. Carreon L.Y., Ito T., Yamada M., Uchiyama S., and Takahashi H.E. Neovascularization induced by anulus and its inhibition by cartilage endplate: its role in disc absorption. Spine 22 (1997) 1429-1434
10. Moses M.A., Sudhalter J., and Langer R. Identification of an inhibitor of neovascularization from cartilage. Science 248 (1990) 1408-1410
11. Virri J., Sikk S., Grönblad M., Tolonen J., Seitsalo S., Kankare J., et al. Concomitant immunocytochemical study of macrophage cells and blood vessels in disc herniation tissue. Eur Spine J 3 (1994) 336-341
12. Ikeda T., Nakamura T., Kikuchi T., Umeda S., Senda H., and Takagi K. Pathomechanism of spontaneous regression of herniated lumbar disc: histologic and immunohistochemical study. J Spinal Disord 9 (1996) 136-140
13. Brock M., Patt S., and Mayer H.M. The form and structure of the extruded disc. Spine 17 (1992) 1457-1461
14. Adams M.A., and Hutton W.C. Prolapsed intervertebral disc: a hyperflexion injury. Spine 7 (1982) 184-191
15. McNally D.S., Adams M.A., and Goodship A.E. Can intervertebral disc prolapse be predicted from disc mechanics?. Spine 18 (1993) 1525-1530
16. Adams M.A., and Hutton W.C. Gradual disc prolapse. Spine 10 (1985) 524-531
17. Gordon S.J., Yang K.H., Mayer P.J., Mace A.H., Kish V.L., and Radin E.L. Mechanism of disc rupture: a preliminary report. Spine 16 (1991) 450-456
18. Adams M.A., Dolan P., and Hutton W.C. The lumbar spine in backward bending. Spine 13 (1988) 1019-1026
19. Adams M.A. Biomechanics of back pain. Acupunct Med 22 (2004) 178-188
20. Zhang Y.H., Zhao C.Q., Jiang L.S., Chen X.D., and Dai L.Y. Modic changes: a systematic review of the literature. Eur Spine J 17 10 (2008) 1289-1299
21. Brinckmann P., Frobin W., Hierholzer E., and Horst M. Deformation of the vertebral endplate under axial loading of the spine. Spine 8 (1983) 851-856
22. Brinckmann P., and Grootenboer H. Change of disc height, radial disc bulge, and intradiscal pressure from discectomy: an in vitro investigation on human lumbar discs. Spine 16 (1991) 641-646
23. Adams M.A., McNally D.S., and Dolan P. Stress distributions inside intervertebral discs: the effects of age and degeneration. J Bone Joint Surg [Br] 78 (1996) 965-972
24. Nachemson A. In vivo discometry in lumbar discs with irregular nucleograms. Acta Orthop Scand 36 (1965) 418-434
25. Brinckmann P., and Horst M. The influence of vertebral body fracture, intradiscal injection, and partial discectomy on the radial bulge and height of human lumbar discs. Spine 10 (1985) 138-145
26. Adams M.A., McMillan D.W., Green T.P., and Dolan P. Sustained loading generates stress concentrations in lumbar intervertebral discs. Spine 21 (1996) 434-438
27. Seroussi R.E., Krag M.H., Muller D.L., and Pope M.H. Internal deformations of intact and denucleated human lumbar discs subjected to compression, flexion, and extension loads. J Orthop Res 7 (1989) 122-131
28. Adams M.A., Freeman B.J., Morrison H.P., Nelson I.W., and Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine 25 13 (2000) 1625-1636
29. Roberts S., Menage J., and Urban J.P. Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine 14 (1989) 166-174
30. Moore R.J., Osti O.L., Vernon-Roberts B., and Fraser R.D. Changes in endplate vascularity after an outer anulus tear in the sheep. Spine 17 (1992) 874-878
31. Urban J.P., Smith S., and Fairbank J.C. Nutrition of the intervertebral disc. Spine 29 (2004) 2700-2709