Development and validation of an enzyme linked immunosorbent assay for the quantification of carcinoembryonic antigen in mouse plasma

Journal of Immunoassay and Immunochemistry

Volumn 30, Issue 4, 2009, Pages 418-427

  Urva, Shweta R ^a   Yang, Victor C ^b   Balthasar, Joseph P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Athymic mice; Carcinoembryonic antigen (CEA); ELISA; Plasma; Shed antigen; Xenograft

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLEARANCE; COLORECTAL CANCER; CONTROLLED STUDY; DISTRIBUTION VOLUME; ENZYME LINKED IMMUNOSORBENT ASSAY; HALF LIFE TIME; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TUMOR XENOGRAFT; ADENOCARCINOMA; ANIMAL; BLOOD; CANCER TRANSPLANTATION; COLORECTAL TUMOR; HUMAN; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE; VALIDATION STUDY;

ADENOCARCINOMA; ANIMALS; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SENSITIVITY AND SPECIFICITY;

EID: 70449727195     PISSN: 15321819     EISSN: 15324230     Source Type: Journal    
DOI: 10.1080/15321810903188227     Document Type: Article

References (17)

1. Gold, P.; Freedman, S.O. Specific carcinoembryonic antigens of the human digestive system. J. Exp. Med. 1965, 122, 467-481.
2. Gold, P.; Freedman, S.O. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 1965, 121, 439-462.
3. Prall, F.; Nollau, P.; Neumaier, M.; Haubeck, H.D.; Drzeniek, Z.; Helmchen, U.; Loning, T.; Wagener, C. CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. J. Histochem. Cytochem. 1996, 44, 35-41.
4. Nap, M.; Hammarstrom, M.L.; Bormer, O.; Hammarstrom, S.; Wagener, C.; Handt, S.; Schreyer, M.; Mach, J.P.; Buchegger, F.; von Kleist, S.; Grunert, F.; Seguin, P.; Fuks, A.; Holam, R.; Lamerz, R. Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen. Cancer. Res. 1992, 52, 2329-2339.
5. Hammarstrom, S. The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer. Biol. 1999, 9, 67-81.
6. Thomson, D.M.; Krupey, J.; Freedman, S.O.; Gold, P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc. Natl. Acad. Sci. 1969, 64, 161-167.
7. Hedin, A.; Carlsson, L.; Berglund, A.; Hammarstrom, S. A monoclonal antibody-enzyme immunoassay for serum carcinoembryonic antigen with increased specificity for carcinomas. Proc. Natl. Acad. Sci. 1983, 80, 3470-3474.
8. Wagener, C.; Yang, Y.H.; Crawford, F.G.; Shively, J.E. Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: A systematic approach for the determination of epitope specificities of monoclonal antibodies. J. Immunol. 1983, 130, 2308-2315.
9. Neumaier, M.; Fenger, U.; Wagener, C. Monoclonal antibodies for carcinoembryonic antigen (CEA) as a model system: Identification of two novel CEA-related antigens in meconium and colorectal carcinoma tissue by western blots and differential immunoaffinity chromatography. J. Immunol. 1985, 135, 3604-3609.
10. Wagener, C.; Clark, B.R.; Rickard, K.J.;, Shively, J.E. Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: Determination of affinities and specificities of monoclonal antibodies by using biotin-labeled antibodies and avidin as precipitating agent in a solution phase immunoassay. J. Immunol. 1983, 130, 2302-2307.
11. Stragand, J.J.; Yang, L.Y.; Drewinko, B. Serum CEA levels in a human colonic adenocarcinoma (LOVO) xenograft system. Cancer. Lett. 1980, 10, 45-50.
12. Lewis, J.C.; Keep, P.A. Relationship of serum CEA levels to tumour size and CEA content in nude mice bearing colonic-tumour xenografts. Br. J. Cancer. 1981, 44, 381-387.
13. Staab, H.J.; Anderer, F.A. Growth of human colonic adenocarcinoma and development of serum CEA in in athymic mice. I: Strict correlation of tumour size and mass with serum CEA concentration during logarithmic growth. Br. J. Cancer 1982, 46, 841-847.
14. Martin, K.W.; Halpern, S.E. Carcinoembryonic antigen production, secretion, and kinetics in BALB=c mice and a nude mouse-human tumor model. Cancer Res. 1984, 44, 5475-5481.
15. Bivins, B.A.; Meeker, W.R. Jr.; Griffen, W.O. Jr.; Pellegrini, J.; Parker, J.C. Jr. Carcinoembryonic antigen (CEA) levels and tumor histology in colon cancer. J. Surg. Res. 1975, 18, 257-261.
16. Toth, C.A.; Thomas, P.; Broitman, S.A.; Zamcheck, N. Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells. Cancer Res. 1985, 45, 392-397.
17. Molnar, I.G.; Vandevoorde, J.P.; Gitnick, G.L. CEA levels in fluids bathing gastrointestinal tumors. Gastroenterology 1976, 70, 513-515.