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Volumn 10, Issue , 2009, Pages 474-

The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; RNA;

EID: 70449726777     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-10-474     Document Type: Article
Times cited : (23)

References (64)
  • 1
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: pathophysiology and therapeutics
    • 10.1016/S1471-4914(02)02317-1, 11927290
    • Semenza G. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends in molecular medicine 2002, 8:S62-S67. 10.1016/S1471-4914(02)02317-1, 11927290.
    • (2002) Trends in molecular medicine , vol.8
    • Semenza, G.1
  • 2
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • 10.1038/nrc1187, 13130303
    • Semenza G. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3:721-732. 10.1038/nrc1187, 13130303.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.1
  • 4
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia--a key regulatory factor in tumour growth
    • 10.1038/nrc704, 11902584
    • Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002, 2:38-47. 10.1038/nrc704, 11902584.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 5
    • 33746215136 scopus 로고    scopus 로고
    • Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene
    • Bosco MC, Puppo M, Santangelo C, Anfosso L, Pfeffer U, Fardin P, Battaglia F, Varesio L. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. J Immunol 2006, 177:1941-1955.
    • (2006) J Immunol , vol.177 , pp. 1941-1955
    • Bosco, M.C.1    Puppo, M.2    Santangelo, C.3    Anfosso, L.4    Pfeffer, U.5    Fardin, P.6    Battaglia, F.7    Varesio, L.8
  • 8
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • 1850121, 10934146
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000, 157:411-421. 1850121, 10934146.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 9
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • 2192245, 7500013, 10.1084/jem.182.6.1683
    • Melillo G, Musso T, Sica A, Taylor L, Cox G, Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 1995, 182:1683-1693. 2192245, 7500013, 10.1084/jem.182.6.1683.
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.4    Cox, G.5    Varesio, L.6
  • 10
    • 0033231301 scopus 로고    scopus 로고
    • Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
    • Melillo G, Sausville E, Cloud K, Lahusen T, Varesio L, Senderowicz A. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res 1999, 59:5433-5437.
    • (1999) Cancer Res , vol.59 , pp. 5433-5437
    • Melillo, G.1    Sausville, E.2    Cloud, K.3    Lahusen, T.4    Varesio, L.5    Senderowicz, A.6
  • 11
    • 0345170089 scopus 로고    scopus 로고
    • Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts
    • 10.3727/000000003108749062, 14686790
    • Vengellur A, Woods BG, Ryan HE, Johnson RS, LaPres JJ. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr 2003, 11:181-197. 10.3727/000000003108749062, 14686790.
    • (2003) Gene Expr , vol.11 , pp. 181-197
    • Vengellur, A.1    Woods, B.G.2    Ryan, H.E.3    Johnson, R.S.4    LaPres, J.J.5
  • 14
    • 33750475218 scopus 로고    scopus 로고
    • Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
    • 1794547, 16989664, 10.1186/gb-2006-7-9-r84
    • De Preter K, Vandesompele J, Heimann P, Yigit N, Beckman S, Schramm A, Eggert A, Stallings R, Benoit Y, Renard M. Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes. Genome Biology 2006, 7:R84. 1794547, 16989664, 10.1186/gb-2006-7-9-r84.
    • (2006) Genome Biology , vol.7
    • De Preter, K.1    Vandesompele, J.2    Heimann, P.3    Yigit, N.4    Beckman, S.5    Schramm, A.6    Eggert, A.7    Stallings, R.8    Benoit, Y.9    Renard, M.10
  • 15
    • 0002749582 scopus 로고    scopus 로고
    • Neuroblastoma
    • London: Kluwer Academic, Master JRW, Palsson B
    • Thiele CJ. Neuroblastoma. Human Cell Culture 1999, 21-22. London: Kluwer Academic, Master JRW, Palsson B.
    • (1999) Human Cell Culture , pp. 21-22
    • Thiele, C.J.1
  • 16
    • 34250683435 scopus 로고    scopus 로고
    • Neuroblastoma
    • 10.1016/S0140-6736(07)60983-0, 17586306
    • Maris J, Hogarty M, Bagatell R, Cohn S. Neuroblastoma. Lancet 2007, 369:2106-2120. 10.1016/S0140-6736(07)60983-0, 17586306.
    • (2007) Lancet , vol.369 , pp. 2106-2120
    • Maris, J.1    Hogarty, M.2    Bagatell, R.3    Cohn, S.4
  • 17
    • 0038697907 scopus 로고    scopus 로고
    • Advances in the diagnosis and treatment of neuroblastoma
    • 10.1634/theoncologist.8-3-278, 12773750
    • Weinstein J, Katzenstein H, Cohn S. Advances in the diagnosis and treatment of neuroblastoma. Oncologist 2003, 8:278-292. 10.1634/theoncologist.8-3-278, 12773750.
    • (2003) Oncologist , vol.8 , pp. 278-292
    • Weinstein, J.1    Katzenstein, H.2    Cohn, S.3
  • 18
    • 0037076385 scopus 로고    scopus 로고
    • Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
    • 124521, 12011461, 10.1073/pnas.102660199
    • Jogi A, Ora I, Nilsson H, Lindeheim A, Makino Y, Poellinger L, Axelson H, Pahlman S. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. PNAS 2002, 99:7021-7026. 124521, 12011461, 10.1073/pnas.102660199.
    • (2002) PNAS , vol.99 , pp. 7021-7026
    • Jogi, A.1    Ora, I.2    Nilsson, H.3    Lindeheim, A.4    Makino, Y.5    Poellinger, L.6    Axelson, H.7    Pahlman, S.8
  • 19
    • 35748932917 scopus 로고    scopus 로고
    • A review of feature selection techniques in bioinformatics
    • 10.1093/bioinformatics/btm344, 17720704
    • Saeys Y, Inza I, Larranaga P. A review of feature selection techniques in bioinformatics. Bioinformatics 2007, 23:2507-2517. 10.1093/bioinformatics/btm344, 17720704.
    • (2007) Bioinformatics , vol.23 , pp. 2507-2517
    • Saeys, Y.1    Inza, I.2    Larranaga, P.3
  • 21
    • 0037076322 scopus 로고    scopus 로고
    • Selection bias in gene extraction on the basis of microarray gene-expression data
    • 124442, 11983868, 10.1073/pnas.102102699
    • Ambroise C, McLachlan G. Selection bias in gene extraction on the basis of microarray gene-expression data. Proc Natl Acad Sci USA 2002, 99:6562-6566. 124442, 11983868, 10.1073/pnas.102102699.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6562-6566
    • Ambroise, C.1    McLachlan, G.2
  • 22
    • 0031334221 scopus 로고    scopus 로고
    • Selection of relevant features and examples in machine learning
    • Blum AL, Langley P. Selection of relevant features and examples in machine learning. Artif Intell 1997, 97:245-271.
    • (1997) Artif Intell , vol.97 , pp. 245-271
    • Blum, A.L.1    Langley, P.2
  • 24
    • 2942731012 scopus 로고    scopus 로고
    • An extensive empirical study of feature selection metrics for text classification
    • Forman G. An extensive empirical study of feature selection metrics for text classification. J Mach Learn Res 2003, 3:1289-1306.
    • (2003) J Mach Learn Res , vol.3 , pp. 1289-1306
    • Forman, G.1
  • 27
    • 0036161259 scopus 로고    scopus 로고
    • Gene selection for cancer classification using support vector machines
    • Guyon I, Weston J, Barnhill S, Vapnik V. Gene selection for cancer classification using support vector machines. Machine Learning 2002, 46:389-422.
    • (2002) Machine Learning , vol.46 , pp. 389-422
    • Guyon, I.1    Weston, J.2    Barnhill, S.3    Vapnik, V.4
  • 28
    • 2942602999 scopus 로고    scopus 로고
    • Entropy-based gene ranking without selection bias for the predictive classification of microarray data
    • 293475, 14604446, 10.1186/1471-2105-4-54
    • Furlanello C, Serafini M, Merler S, Jurman G. Entropy-based gene ranking without selection bias for the predictive classification of microarray data. BMC Bioinformatics 2003, 4:54. 293475, 14604446, 10.1186/1471-2105-4-54.
    • (2003) BMC Bioinformatics , vol.4 , pp. 54
    • Furlanello, C.1    Serafini, M.2    Merler, S.3    Jurman, G.4
  • 29
    • 0031211090 scopus 로고    scopus 로고
    • A decision-theoretic generalization of on-line learning and an application to boosting
    • Freund Y, Schapire RE. A decision-theoretic generalization of on-line learning and an application to boosting. Journal of Computer and System Sciences 1997, 55:119-139.
    • (1997) Journal of Computer and System Sciences , vol.55 , pp. 119-139
    • Freund, Y.1    Schapire, R.E.2
  • 32
    • 0033281701 scopus 로고    scopus 로고
    • Improved Boosting Using Confidence-rated Predictions
    • Schapire RE, Singer Y. Improved Boosting Using Confidence-rated Predictions. Machine Learning 1999, 37:297-336.
    • (1999) Machine Learning , vol.37 , pp. 297-336
    • Schapire, R.E.1    Singer, Y.2
  • 33
    • 0034164230 scopus 로고    scopus 로고
    • Additive logistic regression: A statistical view of boosting
    • Friedman J, Hastie T, Tibshirani R. Additive logistic regression: A statistical view of boosting. Annals of Statistics 2000, 28:337-374.
    • (2000) Annals of Statistics , vol.28 , pp. 337-374
    • Friedman, J.1    Hastie, T.2    Tibshirani, R.3
  • 36
    • 62549127689 scopus 로고    scopus 로고
    • Elastic Net Regularization in Learning Theory
    • 10.1016/j.jco.2009.01.002
    • De Mol C, De Vito E, Rosasco L. Elastic Net Regularization in Learning Theory. Journal of Complexity 25(2):201-230. 10.1016/j.jco.2009.01.002.
    • Journal of Complexity , vol.25 , Issue.2 , pp. 201-230
    • De Mol, C.1    De Vito, E.2    Rosasco, L.3
  • 38
    • 67649271550 scopus 로고    scopus 로고
    • A Regularized Method for Selecting Nested Groups of Relevant Genes from Microarray Data
    • 10.1089/cmb.2008.0171, 19432538
    • De Mol C, Mosci S, Traskine M, Verri A. A Regularized Method for Selecting Nested Groups of Relevant Genes from Microarray Data. Journal of Computational Biology 2009, 16:677-690. 10.1089/cmb.2008.0171, 19432538.
    • (2009) Journal of Computational Biology , vol.16 , pp. 677-690
    • De Mol, C.1    Mosci, S.2    Traskine, M.3    Verri, A.4
  • 39
    • 17744400301 scopus 로고    scopus 로고
    • N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
    • 145518, 11250904, 10.1093/emboj/20.6.1383
    • Boon K, Caron H, van Asperen R, Valentijn L, Hermus M, van Sluis P, Roobeek I, Weis I, Voute P, Schwab M. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J 2001, 20:1383-1393. 145518, 11250904, 10.1093/emboj/20.6.1383.
    • (2001) EMBO J , vol.20 , pp. 1383-1393
    • Boon, K.1    Caron, H.2    van Asperen, R.3    Valentijn, L.4    Hermus, M.5    van Sluis, P.6    Roobeek, I.7    Weis, I.8    Voute, P.9    Schwab, M.10
  • 42
    • 33646765735 scopus 로고    scopus 로고
    • Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes
    • 10.1152/physiolgenomics.00315.2005, 16507782
    • Mense SM, Sengupta A, Zhou M, Lan C, Bentsman G, Volsky DJ, Zhang L. Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics 2006, 25:435-449. 10.1152/physiolgenomics.00315.2005, 16507782.
    • (2006) Physiol Genomics , vol.25 , pp. 435-449
    • Mense, S.M.1    Sengupta, A.2    Zhou, M.3    Lan, C.4    Bentsman, G.5    Volsky, D.J.6    Zhang, L.7
  • 43
    • 37549043844 scopus 로고    scopus 로고
    • Transcriptional adaptation of neuroblastoma cells to hypoxia
    • 10.1016/j.bbrc.2007.12.074, 18155155
    • Fredlund E, Ovenberger M, Borg K, Pahlman S. Transcriptional adaptation of neuroblastoma cells to hypoxia. Biochem Biophys Res Commun 2008, 366:1054-1060. 10.1016/j.bbrc.2007.12.074, 18155155.
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 1054-1060
    • Fredlund, E.1    Ovenberger, M.2    Borg, K.3    Pahlman, S.4
  • 45
    • 1842861743 scopus 로고    scopus 로고
    • Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior
    • 10.1016/j.yexcr.2004.01.013, 15093745
    • Jogi A, Vallon-Christersson J, Holmquist L, Axelson H, Borg A, Pahlman S. Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior. Exp Cell Res 2004, 295:469-487. 10.1016/j.yexcr.2004.01.013, 15093745.
    • (2004) Exp Cell Res , vol.295 , pp. 469-487
    • Jogi, A.1    Vallon-Christersson, J.2    Holmquist, L.3    Axelson, H.4    Borg, A.5    Pahlman, S.6
  • 46
    • 0035027828 scopus 로고    scopus 로고
    • Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
    • 100265, 11313469, 10.1128/MCB.21.10.3436-3444.2001
    • Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol 2001, 21:3436-3444. 100265, 11313469, 10.1128/MCB.21.10.3436-3444.2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 3436-3444
    • Seagroves, T.N.1    Ryan, H.E.2    Lu, H.3    Wouters, B.G.4    Knapp, M.5    Thibault, P.6    Laderoute, K.7    Johnson, R.S.8
  • 47
    • 0029858079 scopus 로고    scopus 로고
    • Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1
    • 10.1111/j.1432-1033.1996.00403.x, 8917436
    • O'Rourke JF, Pugh CW, Bartlett SM, Ratcliffe PJ. Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1. Eur J Biochem 1996, 241:403-410. 10.1111/j.1432-1033.1996.00403.x, 8917436.
    • (1996) Eur J Biochem , vol.241 , pp. 403-410
    • O'Rourke, J.F.1    Pugh, C.W.2    Bartlett, S.M.3    Ratcliffe, P.J.4
  • 49
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • 10.1126/stke.3062005re12, 16234508
    • Wenger R, Stiehl D, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005, 2005:re12. 10.1126/stke.3062005re12, 16234508.
    • (2005) Sci STKE , vol.2005
    • Wenger, R.1    Stiehl, D.2    Camenisch, G.3
  • 50
    • 1942453828 scopus 로고    scopus 로고
    • Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway
    • 387743, 15082785, 10.1128/MCB.24.9.3918-3927.2004
    • Lee M, Kim J, Suk K, Park J. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol 2004, 24:3918-3927. 387743, 15082785, 10.1128/MCB.24.9.3918-3927.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 3918-3927
    • Lee, M.1    Kim, J.2    Suk, K.3    Park, J.4
  • 51
    • 33749494456 scopus 로고    scopus 로고
    • Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    • 10.1158/0008-5472.CAN-06-0101, 16982742
    • Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 2006, 66:9009-9016. 10.1158/0008-5472.CAN-06-0101, 16982742.
    • (2006) Cancer Res , vol.66 , pp. 9009-9016
    • Chen, H.1    Yan, Y.2    Davidson, T.L.3    Shinkai, Y.4    Costa, M.5
  • 52
    • 0141853227 scopus 로고    scopus 로고
    • Analysis of the effect of aging on the response to hypoxia by cDNA microarray
    • 10.1016/S0047-6374(03)00166-0, 14499499
    • Kim H, Lee DK, Choi JW, Kim JS, Park SC, Youn HD. Analysis of the effect of aging on the response to hypoxia by cDNA microarray. Mech Ageing Dev 2003, 124:941-949. 10.1016/S0047-6374(03)00166-0, 14499499.
    • (2003) Mech Ageing Dev , vol.124 , pp. 941-949
    • Kim, H.1    Lee, D.K.2    Choi, J.W.3    Kim, J.S.4    Park, S.C.5    Youn, H.D.6
  • 54
    • 11244315697 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    • 10.1182/blood-2004-07-2958, 15374877
    • Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 2005, 105:659-669. 10.1182/blood-2004-07-2958, 15374877.
    • (2005) Blood , vol.105 , pp. 659-669
    • Manalo, D.J.1    Rowan, A.2    Lavoie, T.3    Natarajan, L.4    Kelly, B.D.5    Ye, S.Q.6    Garcia, J.G.7    Semenza, G.L.8
  • 56
    • 43349088950 scopus 로고    scopus 로고
    • Hypoxia transcriptionally induces macrophage-inflammatory protein-3 alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappa B
    • 10.1189/jlb.0607349, 18089854
    • Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC. Hypoxia transcriptionally induces macrophage-inflammatory protein-3 alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappa B. Journal of Leukocyte Biology 2008, 83:648-662. 10.1189/jlb.0607349, 18089854.
    • (2008) Journal of Leukocyte Biology , vol.83 , pp. 648-662
    • Battaglia, F.1    Delfino, S.2    Merello, E.3    Puppo, M.4    Piva, R.5    Varesio, L.6    Bosco, M.C.7
  • 57
    • 0036101635 scopus 로고    scopus 로고
    • Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma
    • 10.1002/ijc.10392, 12115498
    • Rapella A, Negrioli A, Melillo G, Pastorino S, Varesio L, Bosco MC. Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. Int J Cancer 2002, 99:658-664. 10.1002/ijc.10392, 12115498.
    • (2002) Int J Cancer , vol.99 , pp. 658-664
    • Rapella, A.1    Negrioli, A.2    Melillo, G.3    Pastorino, S.4    Varesio, L.5    Bosco, M.C.6
  • 59
    • 84872521038 scopus 로고    scopus 로고
    • R: A language and environment for statistical
    • R Development Core Team R: A language and environment for statistical. R Foundation for Statistical Computing 2004,
    • (2004) R Foundation for Statistical Computing
  • 60
    • 1342288026 scopus 로고    scopus 로고
    • Affy--analysis of Affymetrix GeneChip data at the probe level
    • 10.1093/bioinformatics/btg405, 14960456
    • Gautier L, Cope L, Bolstad BM, Irizarry RA. affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004, 20:307-315. 10.1093/bioinformatics/btg405, 14960456.
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 61
    • 34548583274 scopus 로고    scopus 로고
    • A tutorial on spectral clustering
    • von Luxburg U. A tutorial on spectral clustering. Statistics and Computing 2007, 17:395-416.
    • (2007) Statistics and Computing , vol.17 , pp. 395-416
    • von Luxburg, U.1
  • 62
    • 38349106729 scopus 로고    scopus 로고
    • Algebraic stability indicators for ranked lists in molecular profiling
    • 10.1093/bioinformatics/btm550, 18024475
    • Jurman G, Merler S, Barla A, Paoli S, Galea A, Furlanello C. Algebraic stability indicators for ranked lists in molecular profiling. Bioinformatics 2007, 24:258-264. 10.1093/bioinformatics/btm550, 18024475.
    • (2007) Bioinformatics , vol.24 , pp. 258-264
    • Jurman, G.1    Merler, S.2    Barla, A.3    Paoli, S.4    Galea, A.5    Furlanello, C.6
  • 63
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
    • 10.1016/S1471-4914(01)02090-1, 11516994
    • Semenza G. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001, 7:345-350. 10.1016/S1471-4914(01)02090-1, 11516994.
    • (2001) Trends Mol Med , vol.7 , pp. 345-350
    • Semenza, G.1
  • 64
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • 10.1016/j.cmet.2006.02.002, 16517405
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006, 3:177-185. 10.1016/j.cmet.2006.02.002, 16517405.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4


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