Identification of Genes Associated With Progression and Metastasis of Advanced Cervical Cancers After Radiotherapy by cDNA Microarray Analysis

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 4, 2009, Pages 1232-1239

  Harima, Yoko ^a   Ikeda, Koshi ^a   Utsunomiya, Keita ^a   Shiga, Toshiko ^a   Komemushi, Atsushi ^a   Kojima, Hiroyuki ^b   Nomura, Motoo ^b   Kamata, Minoru ^b   Sawada, Satoshi ^b  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY HOSPITAL   (Japan)

Author keywords

cDNA microarray; Cervical cancer; Gene expression profiles; Metastasis; Prediction

Indexed keywords

ACCURATE PREDICTION; CDNA MICROARRAY ANALYSIS; CDNA MICROARRAYS; CERVICAL CANCERS; CHROMOSOMAL INSTABILITY; CLUSTERING ANALYSIS; CROSS-VALIDATION METHODS; CROSS-VALIDATION TESTS; DEFINITIVE RADIOTHERAPY; DISTANT METASTASIS; EXPRESSION PROFILE; EXTRACELLULAR MATRIX COMPONENTS; HUMAN GENES; HUMAN PAPILLOMAVIRUS; LEAVE-ONE-OUT; LOCAL FAILURE; MATRIX METALLOPROTEINASE-1; P53 GENE; PREDICTIVE METHODS; PROTEIN PHOSPHATASE-1; REGULATORY SUBUNITS; THERAPEUTIC TARGETS; WILD TYPES;

BIOACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; ONCOLOGY; RADIOTHERAPY; TUMORS;

PATHOLOGY;

COMPLEMENTARY DNA; INTERSTITIAL COLLAGENASE; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN P53; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7; UNCLASSIFIED DRUG;

ADVANCED CANCER; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; CARCINOGENESIS; CHROMOSOMAL INSTABILITY; CLINICAL ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISTANT METASTASIS; DNA MICROARRAY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PUNCH BIOPSY; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; UNINDEXED SEQUENCE; UTERINE CERVIX CANCER; VALIDITY; VIRUS INFECTION; WART VIRUS; WILD TYPE; DISEASE COURSE; GENETICS; NONPARAMETRIC TEST; PATHOLOGY; PREDICTION AND FORECASTING; TUMOR GENE; TUMOR SUPPRESSOR GENE; UPREGULATION; UTERINE CERVIX TUMOR;

DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENES, NEOPLASM; GENES, P53; GENETIC MARKERS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 70449723685     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.07.002     Document Type: Article

References (36)

1. Schiffman M., Castle P.E., Jeronimo J., et al. Human papillomavirus and cervical cancer. Lancet 370 (2007) 890-907
2. Harima Y., Harima K., Shikata N., et al. Bax and Bcl-2 expression predict response to radiotherapy in human cervical cancer. J Cancer Res Clin Oncol 124 (1998) 503-510
3. Harima Y., Sawada S., Miyazaki Y., et al. Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival. Am J Clin Oncol 26 (2003) e80-e86
4. Ishikawa H., Sakurai H., Hasegawa M., et al. Expression of hypoxic-inducible factor 1α predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. Int J Radiat Oncol Biol Phys 60 (2004) 513-521
5. Kim G.E., Kim Y.B., Cho N.H., et al. Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix. A potential predictor of poor survival. Clin Cancer Res 10 (2004) 1366-1374
6. Shim C., Zhang W., Rhee C.H., et al. Profiling of differentially expressed genes in human primary cervical cancer by complementary DNA expression array. Clin Cancer Res 4 (1998) 3045-3050
7. Hudelist G., Czerwenka K., Singer C., et al. cDNA array analysis of cytobrush-collected normal and malignant cervical epithelial cells: A feasibility study. Cancer Genet Cytogenet 158 (2005) 35-42
8. Roepman P., Wessels L.F., Kettelarij N., et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet 37 (2005) 182-186
9. Hagemann T., Bozanovic T., Hooper S., et al. Molecular profiling of cervical cancer progression. Brit J Cancer 96 (2007) 321-328
10. International Federation of Gynecologists and Obstetricians. Changes in definitios of clinical staging for carcinoma of the cervix and ovary. Am J Obstet Gynecol 156 (1987) 263
11. Harima Y., Harima K., Sawada S., et al. Loss of heterozygosity on chromosome 6p21.2 as a potential marker for recurrence after radiotherapy of human cervical cancer. Clin Cancer Res 6 (2000) 1079-1085
12. International Commission of Radiation Units and Measurements. Dose and volume specification for reporting intracavitary therapy in gynecology. Report No. 38. Bethesda (MD): ICRU (1985) 1-16
13. Luo L., Salunga R.C., Guo H., et al. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nat Med 5 (1999) 117-122
14. Ono K., Tanaka T., Tsunoda T., et al. Identification by cDNA microarray of genes involved in ovarian carcinogenesis. Cancer Res 60 (2000) 5007-5011
15. Kitahara O., Katagiri T., Tsunoda T., et al. Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis. Neoplasia 4 (2002) 295-303
16. Eisen M.B., Spellman P.T., Brown P.O., et al. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 95 (1998) 14863-14868
17. Kan T., Shimada Y., Sato F., et al. Prediction of lymph node metastasis with use of artificial networks based on gene expression profiles in esophageal squamous cell carcinoma. Ann Surg Oncol 11 (2004) 1070-1078
18. Ishikawa H., Mitsuhashi N., Sakurai H., et al. The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with stage IIIB cervical carcinoma treated with radiation therapy alone. Cancer 91 (2001) 80-89
19. Van Trappen P.O., Ryan A., Carroll M., et al. A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer. Br J Cancer 87 (2002) 537-544
20. Vazquez-Ortiz G., Ciudad C.J., Pina P., et al. Gene identification by cDNA arrays in HPV-positive cervical cancer. Arch Med Res 36 (2005) 448-458
21. Martin-Lluesma S., Stucke V.M., and Nigg E.A. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297 (2002) 2267-2270
22. Liu S.T., Chan G.K., Hittle J.C., et al. Human MPS1 kinase is required for mitotic arrest induced by the loss of cenp-e from kinetochores. Mol Biol Cell 14 (2003) 1638-1651
23. Nigg E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2 (2001) 21-32
24. Stucke V.M., Sillje H.H., Arnaud L., et al. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. EMBO J 21 (2002) 1723-1732
25. Salvatore G., Nappi T.C., Salerno P., et al. A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. Cancer Res 67 (2007) 10148-10158
26. Lo Y.L., Yu J.C., Chen S.T., et al. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: A multigenic study on cancer susceptibility. Carcinogenesis 28 (2007) 1079-1086
27. Egeblad M., and Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2 (2002) 161-174
28. Deryugina E.I., and Quigley J.P. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25 (2006) 9-34
29. Murray G.I., Duncan M.E., O'Neil P., et al. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat Med 2 (1996) 461-462
30. Murray G.I., Duncan M.E., O'Neil P., et al. Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 185 (1998) 256-261
31. Ito T., Ito M., Shiozawa J., et al. Expression of the MMP-1 in human pancreatic carcinoma: relationship with prognostic factor. Mod Pathol 12 (1999) 669-674
32. Inoue T., Yashiro M., Nishimura S., et al. Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer. Int J Mol Med 4 (1999) 73-77
33. Brummer O., Bohmer G., Hollwitz B., et al. MMP-1 and MMP-2 in the cervix uteri in different steps of malignant transformation-An immunohistochemical study. Gynecol Oncol 84 (2002) 222-227
34. Moser P.L., Kieback D.G., Hefler L., et al. Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer. Anticancer Res 19 (1999) 4391-4393
35. Takakura S., Kohno T., Manda R., et al. Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Int J Oncol 18 (2001) 817-824
36. Narayan G., Pulido H.A., Koul S., et al. Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progression. Oncogene 22 (2003) 3489-3499