Physiological function of mycobacterial mtFabD, an essential malonyl-CoA:AcpM transacylase of type 2 fatty acid synthase FASII, in yeast mct1Δ cells

Comparative and Functional Genomics

Volumn 2009, Issue , 2009, Pages

  Gurvitz, Aner ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN MALONYLTRANSFERASE; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE II; GLYCEROL; PROTEIN FABD; THIOCTIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; FUNGUS MUTANT; MITOCHONDRION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS;

MYCOBACTERIUM TUBERCULOSIS; SACCHAROMYCES CEREVISIAE;

EID: 70449718950     PISSN: 15316912     EISSN: 15326268     Source Type: Journal    
DOI: 10.1155/2009/836172     Document Type: Article

References (18)

1. R. Veyron-Churlet, S. Bigot, O. Guerrini, et al., "The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions," Journal of Molecular Biology, vol. 353, pp. 847-858, 2005.
2. K. Takayama, C. Wang, and G. S. Besra, "Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis," Clinical Microbiology Reviews, vol. 18, pp. 81-101, 2005.
3. L. Kremer, et al., "Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA: AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II," The Journal of Biological Chemistry, vol. 276, pp. 27967-27974, 2001.
4. E. Sacco, A. S. Covarrubias, H. M. O'Hare, et al., "The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 14628-14633, 2007.
5. R. Schneider, B. Brors, F. Bürger, S. Camrath, and H. Weiss, "Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae," Current Genetics, vol. 32, pp. 384-388, 1997.
6. A. Y. Hsu, W. W. Poon, J. A. Shepherd, D. C. Myles, and C. F. Clarke, "Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: Evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis," Biochemistry, vol. 35, pp. 9797-9806, 1996.
7. 90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae," Applied and Environmental Microbiology, vol. 74, pp. 5078-5085, 2008.
8. J. E. Hill, A. M. Myers, T. J. Koerner, and A. Tzagoloff, "Yeast/ E.coli shuttle vectors with multiple unique restriction sites," Yeast, vol. 2, pp. 163-167, 1986.
9. R. D. Gietz and A. Sugino, "New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites," Gene, vol. 74, pp. 527-534, 1988.
10. D. C. Chen, B. C. Yang, and T. T. Kuo, "One-step transformation of yeast in stationary phase," Current Genetics, vol. 21, pp. 83-84, 1992.
11. M. D. Rose, F.Winston, and P. Heiter, Methods in Yeast Genetics: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA, 1990.
12. J. Sambrook, E. F. Fritsch, and T. Maniatis, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA, 1989.
13. E. Böker-Schmitt, S. Francisci, and R. J. Schweyen, "Mutations releasing mitochondrial biogenesis from glucose repression in Saccharomyces cerevisiae," Journal of Bacteriology, vol. 151, pp. 303-310, 1982.
14. M. A. Hayden, I. Y. Huang, G. Iliopoulos, M. Orozco, and G. W. Ashley, "Biosynthesis of lipoic acid: Characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33- lip9," Biochemistry, vol. 32, pp. 3778-3782, 1993.
15. S. Brody, C. Oh, U. Hoja, and E. Schweizer, "Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae," FEBS Letters, vol. 408, pp. 217-220, 1997.
16. A. Gurvitz, J. K.Hiltunen, and A. J. Kastaniotis, "Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacylthioester dehydratases, HtdX and HtdY, in addition to Had- ABC and HtdZ," Journal of Bacteriology, vol. 191, pp. 2683-2690, 2009.
17. A. Gurvitz, "The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2," Molecular Genetics and Genomics, vol. 282, pp. 407-416, 2009.
18. R. Veyron-Churlet, O. Guerrini, L. Mourey, M. Daffé, and D. Zerbib, "Protein-protein interactions within the fatty acid synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability," Molecular Microbiology, vol. 54, pp. 1161-1172, 2004.