Is preoperative chemoradiotherapy still the treatment of choice for rectal cancer?

Journal of Clinical Oncology

Volumn 27, Issue 31, 2009, Pages 5115-5116

  Minsky, Bruce D ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; EDITORIAL; HUMAN; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RECTUM CANCER; TREATMENT PLANNING; ADJUVANT THERAPY; CLINICAL TRIAL; MULTIMODALITY CANCER THERAPY; NOTE; PREOPERATIVE CARE; RADIOTHERAPY; RECTUM TUMOR;

ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; HUMANS; NEOADJUVANT THERAPY; PREOPERATIVE CARE; RADIOTHERAPY; RECTAL NEOPLASMS;

EID: 70449706216     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2009.22.9112     Document Type: Editorial

References (9)

1. Minsky BD, Cohen AM, Kemeny N, et al: Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol 10:79-84, 1992
2. Minsky BD, Cohen AM, Kemeny N, et al: Combined modality therapy of rectal cancer: Decreased acute toxicity with the preoperative approach. J Clin Oncol 10:1218-1224, 1992
3. Sauer R, Becker H, Hohenberger W, et al: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740, 2004
4. Roh MS, Colangelo LH, O'Connell MJ, et al: Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol 27:5124-5130, 2009
5. Valentini V, Coco C, Picciocchi A, et al: Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients. Int J Radiat Oncol Biol Phys 53:664-674, 2002
6. Guillem JG, Chessin DB, Cohen AM, et al: Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer. Ann Surg 241:829-836, 2005
7. Tepper JE, O'Connell M, Niedzwiecki D, et al: Adjuvant therapy in rectal cancer: Analysis of stage, sex, and local control - Final report of Intergroup 0114. J Clin Oncol 20:1744-1750, 2002
8. Guillem JG, Díaz-González J, Minsky BD, et al: cT3N0 rectal cancer: Potential overtreatment with preoperative chemoradiotherapy is warranted. J Clin Oncol 26:368-373, 2008
9. Sebag-Montefiore D, Stephens RJ, Steele R, et al: Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): A multicentre, randomised trial. Lancet 373:811-820, 2009