Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey

Hypertension

Volumn 54, Issue 5, 2009, Pages 1115-1122

  Bramlage, Carsten Paul ^a   Schlumbohm, Christina ^b   Pryce, Christopher Robert ^c,g   Mirza, Serkan ^c   Schnell, Christian ^d   Amann, Kerstin ^e   Amstrong, Victor William ^a   Eitner, Frank ^b   Zapf, Antonia ^a   Feldon, Joram ^c   Oellerich, Michael ^a   Fuchs, Eberhard ^f   Müller, Gerhard Anton ^a   Strutz, Frank ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b GERMAN PRIMATE CENTER   (Germany)

^c ETH ZURICH   (Switzerland)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^g UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Dexamethasone; Glomeruli number; Hypertension; Marmoset monkeys; Prenatal programming

Indexed keywords

CYSTATIN C; DEXAMETHASONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; GESTATION PERIOD; GLOMERULUS; KIDNEY DISEASE; KIDNEY MASS; MALE; MARMOSET; NEPHRON; NONHUMAN; PRENATAL DRUG EXPOSURE; PRENATAL GROWTH; PRIORITY JOURNAL; PROTEINURIA; ANALYSIS OF VARIANCE; ANIMAL; BLOOD PRESSURE MEASUREMENT; BREEDING; COMPARATIVE STUDY; DRUG EFFECT; HAPLORHINI; METABOLISM; ORGAN SIZE; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; PROBABILITY; REFERENCE VALUE;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; BLOOD PRESSURE DETERMINATION; CALLITHRIX; CYSTATIN C; DEXAMETHASONE; FEMALE; HAPLORHINI; KIDNEY GLOMERULUS; MALE; NEPHRONS; ORGAN SIZE; PREGNANCY; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; PROBABILITY; PROTEINURIA; REFERENCE VALUES;

EID: 70449701934     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.109.136580     Document Type: Article

References (24)

1. Vehaskari VM, Woods LL. Prenatal programming of hypertension: lessons from experimental models. J Am Soc Nephrol. 2005;16:2545-2556.
2. Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;2:577-580.
3. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipi-daemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993;36:62-67.
4. Ortiz LA, Quan A, Zarzar F, Weinberg A, Baum M. Prenatal dexameth-asone programs hypertension and renal injury in the rat. Hypertension. 2003;41:328-334.
5. Wintour EM, Moritz KM, Johnson K, Ricardo S, Samuel CS, Dodic M. Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol. 2003;549:929-935.
6. Celsi G, Kistner A, Aizman R, Eklof AC, Ceccatelli S, de Santiago A, Jacobson SH. Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring. Pediatr Res. 1998; 44:317-322.
7. O'Regan D, Kenyon CJ, Seckl JR, Holmes MC. Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring. J Endocrinol. 2008;196:343-352.
8. Woods LL, Weeks DA. Prenatal programming of adult blood pressure: role of maternal corticosteroids. Am J Physiol Regul Integr Comp Physiol. 2005;289:R955-R962.
9. Woods LL. Maternal glucocorticoids and prenatal programming of hypertension. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1069-R1075.
10. Abbott DH, Barnett DK, Colman RJ, Yamamoto ME, Schultz-Darken NJ. Aspects of common marmoset basic biology and life history important for biomedical research. Comp Med. 2003;53:339-350.
11. Hauser J, Knapman A, Zurcher NR, Pilloud S, Maier C, Diaz-Heijtz R, Forssberg H, Dettling A, Feldon J, Pryce CR. Effects of prenatal dexa-methasone treatment on physical growth, pituitary-adrenal hormones, and performance of motor, motivational, and cognitive tasks in juvenile and adolescent common marmoset monkeys. Endocrinology. 2008;149: 6343-6355.
12. Tauber SC, Schlumbohm C, Schilg L, Fuchs E, Nau R, Gerber J. Intra-uterine exposure to dexamethasone impairs proliferation but not neuronal differentiation in the dentate gyrus of newborn common marmoset monkeys. Brain Pathol. 2006;16:209-217.
13. Schnell CR, Wood JM. Measurement of blood pressure and heart rate by telemetry in conscious, unrestrained marmosets. Am J Physiol. 1993;264: H1509-H1516.
14. Keller G, Zimmer G, Mall G, Ritz E, Amann K. Nephron number in patients with primary hypertension. N Engl J Med. 2003;348:101-108. (Pubitemid 36056716)
15. Schroeder C, Osman AA, Roggenbuck D, Mothes T. IgA-gliadin antibodies, IgA-containing circulating immune complexes, and IgA glomer-ular deposits in wasting marmoset syndrome. Nephrol Dial Transplant. 1999;14:1875-1880.
16. Seckl JR. Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms. Mol Cell Endocrinol. 2001;185:61-71.
17. Finken MJ, Keijzer-Veen MG, Dekker FW, Frolich M, Walther FJ, Romijn JA, van der Heijden BJ, Wit JM; for the Dutch POPS-19 Collaborative Study Group. Antenatal glucocorticoid treatment is not associated with long-term metabolic risks in individuals born before 32 weeks of gestation. Arch Dis Child Fetal Neonatal Ed. 2008;93:F442-F447.
18. Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE. Cardiovascular risk factors after antenatal exposure to beta-methasone: 30-year follow-up of a randomised controlled trial. Lancet. 2005;365:1856-1862.
19. Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci (Lond). 2000;98:137-142.
20. de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, Wolfe-Coote S, Meaney MJ, Levitt NS, Seckl JR. Prenatal dexametha-sone exposure induces changes in nonhuman primate offspring cardiom-etabolic and hypothalamic-pituitary-adrenal axis function. J Clin Invest. 2007;117:1058-1067.
21. Moritz KM, Dodic M, Wintour EM. Kidney development and the fetal programming of adult disease. Bioessays. 2003;25:212-220.
22. Oliveira M, Bessa JM, Mesquita A, Tavares H, Carvalho A, Silva R, Pêgo JM, Cerqueira JJ, Palha JA, Almeida OF, Sousa N. Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids. Biol Psychiatry. 2006;59:844-852.
23. Rea DJ, Heimbach JK, Grande JP, Textor SC, Taler SJ, Prieto M, Larson TS, Cosio FG, Stegall MD. Glomerular volume and renal histology in obese and non-obese living kidney donors. Kidney Int. 2006;70: 1636-1641.
24. Hemachandra AH, Klebanoff MA, Furth SL. Racial disparities in the association between birth weight in the term infant and blood pressure at age 7 years: results from the collaborative perinatal project. J Am Soc Nephrol. 2006;17:2576-2581