Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of Acute Lung Injury (ALI)

Journal of Immunology

Volumn 183, Issue 7, 2009, Pages 4715-4722

  Zarbock, Alexander ^a,c,d   DiStasi, Matthew R ^d   Smith, Emily ^a   Sanders, John M ^a   Kronke, Gerhard ^a   Harry, Brian L ^a   Von Vietinghoff, Sibylle ^d   Buscher, Konrad ^d   Nadler, Jerry L ^a,b   Ley, Klaus ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; CHEMOKINE RECEPTOR CXCR2; LIPOPOLYSACCHARIDE; ALOX15 PROTEIN, MOUSE; AUTACOID; CAFFEIC ACID DERIVATIVE; CINNAMYL 3,4 DIHYDROXYCYANOCINNAMATE; CINNAMYL-3,4-DIHYDROXYCYANOCINNAMATE; MULTIENZYME COMPLEX;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BONE MARROW; CHIMERA; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HEMATOPOIETIC CELL; LUNG GAS EXCHANGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CAPILLARY PERMEABILITY; CELL CULTURE; DISEASE MODEL; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY; MICROCIRCULATION; MORTALITY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SURVIVAL;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ACUTE LUNG INJURY; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; CAFFEIC ACIDS; CAPILLARY PERMEABILITY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; MULTIENZYME COMPLEXES; SURVIVAL ANALYSIS;

EID: 70449700286     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0802592     Document Type: Article

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