Role of cellular cholesterol in pharmacologic preconditioning with cyclosporine in experimental kidney transplantation

American Journal of Nephrology

Volumn 31, Issue 2, 2010, Pages 134-140

  Shihab, Fuad S ^a   Bennett, William M ^b   Andoh, Takeshi F ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Legacy Good Samaritan Hospital   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cholesterol; Cyclosporine; Ischemia reperfusion injury; Kidney transplantation; Statin; Syngeneic

Indexed keywords

CHOLESTEROL; CYCLOSPORIN A; FLUINDOSTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; COLD ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL TRANSPLANTATION; HISTOLOGY; KIDNEY DONOR; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TREATMENT OUTCOME; UPREGULATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CYCLOSPORINE; FATTY ACIDS, MONOUNSATURATED; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDOLES; KIDNEY; KIDNEY CORTEX; KIDNEY TRANSPLANTATION; MALE; RATS; RATS, INBRED F344; REPERFUSION INJURY; TIME FACTORS; TRANSPLANTATION CONDITIONING;

EID: 70449678696     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000259900     Document Type: Article

References (28)

1. Troppman C, Gillingham KJ, Benedetti E, Almond PS, Gruessner RW, Najarian ZJS, Matas AJ: Delayed graft function, acute rejection, and outcome after cadaver renal transplantation: the multivariate analysis. Transplantation 1995; 59: 962-968.
2. Goes N, Urmson J, Ramassar V, Halloran PF: Ischemic acute tubular necrosis induces an extensive local cytokine response: evidence for induction of interferon-gamma, transforming growth factor-beta 1, granulocytemacrophage colony-stimulating factor, interleukin- 2, and interleukin-10. Transplantation 1995; 59: 565-572.
3. Ambros JT, Herrero-Fresneda I, Borau OG, Boira JM: Ischemic preconditioning in solid organ transplantation: from experimental to clinics. Transplant Int 2007; 20: 219-229.
4. Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G: Signal transduction of ischemic preconditioning. Cardiovasc Res 2001; 52: 181-198.
5. Sakr M, Zetti G, Hassanein TI, Farghali H, Nalesnik MA, Gavaler JS, Starzl TE, Van Thiel DH: FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats. Hepatology 1991; 13: 947-951.
6. Sakr M, Zetti G, McClain C, Gavaler J, Nalesnik M, Todo S, Starzl T, Van Thiel D: The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats. Transplantation 1992; 53: 987-991.
7. Yuan CM, Bohen EM, Musio F, Carome MA: Sublethal heat shock and cyclosporine exposure produce tolerance against subsequent cyclosporine toxicity. Am J Physiol 1996; 271: F571-F578.
8. Yang CW, Ahn HJ, Han HJ, Kim WY, Li C, Shin MJ, Kim SK, Park JH, Kim YS, Moon IS, Bang BK: Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney. Transplantation 2001; 72: 1753-1759.
9. Shihab FS, Bennett WM, Andoh TF: Donor preconditioning with a calcineurin inhibitor improves outcome in rat syngeneic kidney transplantation. Transplantation 2009; 87: 326-329.
10. Zager RA, Andoh T, Bennett WM: Renal cholesterol accumulation: a durable response after acute and subacute renal insults. Am J Pathol 2001; 159: 743-752.
11. Yamamato A, Itoh S, Ichihara K: Inhibition of cholesterol synthesis ex vivo and in vivo by fluvastatin, a new inhibitor of 3-hydroxy- 3-methylglutaryl coenzyme A reductase. Experientia 1995; 51: 223-226.
12. Presti FT, Pace RJ, Chan SI: Cholesterolphospholipid interaction in membranes. II. Stoichiometry and molecular packaging of cholesterol-rich domains. Biochemistry 1982; 21: 3831-3835.
13. Fielding CJ, Fielding PE: Intracellular cholesterol transport. J Lipid Res 1997; 38: 1503-1521.
14. Zager RA, Burkhart KM, Johnson ACM, Sacks BM: Increased proximal tubular cholesterol content: implications for cell injury and 'acquired cytoresistance'. Kidney Int 1999; 56: 1788-1797.
15. Zager RA: Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack. Kidney Int 2000; 58: 193-205.
16. Zager RA, Johnson ACM, Naito M, Bomsztyk K: Maleate nephrotoxicity: mechanisms of injury and correlates with ischemia/hypoxic tubular cell death. Am J Physiol Renal Physiol 2008; 294:F187-F197.
17. Li HY, Applelbaum FR, Willman CL, Zager RA, Banker DE: Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. Blood 2003; 101: 3628-3634.
18. Mestril R, Chi SH, Sayen MR, O'Reilly K, Dillmann WH: Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia- induced injury. J Clin Invest 1994; 93: 759-767.
19. Plumier JC, Ross BM, Currie RW, Angelidis CE, Kazlaris H, Kollias G, Pagoulatos GN: Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest 1995; 95: 1854-1860.
20. Polla BS, Kantengwa S, François D, Salvioli S, Franceschi C, Marsac C, Cossarizza A: Mitochondria are selective targets for the protective effects of heat shock protein against oxidative stress. Proc Natl Acad Sci USA 1996; 93: 6458-6463.
21. Mosser DD, Caron AW, Bourget L, Denis- Larose C, Massie B: Role of the human heat shock protein hsp70 in protection against strss-induced apoptosis. Mol Cell Biol 1997; 17: 5317-5327.
22. Azuma H, Nadeau K, Takada M, Mackenzie HS, Tilney NL: Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney. Transplantation 1997; 64: 190-197.
23. Haslinger-Löffler B: Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function. Kidney Int 2008; 74: 553-555.
24. Fried LF, Orchard TJ, Kasiske BL: Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 2001; 59: 260-269.
25. Sharyo S, Yokota-Ikeda N, Mori M, Kumagai K, Uchida K, Ito K, Burne-Taney MJ, Rabb H, Ikeda M: Pravastatin improves renal ischemia- reperfusion injury by inhibiting the mevalonate pathway. Kidney Int 2008; 74: 577-584.
26. Zager RA, Kalhorn TF: Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance. Am J Pathol 2000; 157: 1007-1016.
27. Naito M, Bomsztyk K, Zager RA: Renal ischemia- induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene. Am J Pathol 2009; 174: 54-62.
28. Zager RA, Johnson ACM, Hanson SY, Shah VO: Acute tubular injury causes dysregulation of cellular cholesterol transport proteins. Am J Pathol 2003; 163: 313-320.